DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4017 and Cpa4

DIOPT Version :9

Sequence 1:	NP_609309.1	Gene:	CG4017 / 34296	FlyBaseID:	FBgn0032143	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001102816.1	Gene:	Cpa4 / 502736	RGDID:	1563619	Length:	421	Species:	Rattus norvegicus

Alignment Length:	425	Identity:	150/425 - (35%)
Similarity:	235/425 - (55%)	Gaps:	33/425 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKLLLL---LLSVNILIFCLAERQRFDNYKVYRVSPVKANQLEGLRSLEANSEDALVLNNLHLGP 62
            ||.||.   |:...|     ..|.:|...:|:|::....:::..|..| .||:...:  |:...|
  Rat     1 MKWLLFFGALIGTGI-----CGRDKFFGDQVFRINVRNGDEIRKLTEL-VNSDHFKL--NVWKSP 57

  Fly    63 TDF-----LVAPDFD----GTFLKLVKDLDLSPELIDANAQTSLSLDIEPIA--DANRRSDDYSW 116
            :.|     ::.|...    .:||| .:.||.| ..|| |.|..|.::.|.:.  :...||.|:::
  Rat    58 STFDRPVDILVPSVSLLPVKSFLK-SQGLDYS-VTID-NLQALLDIEDEEMQHNEGRERSGDFNY 119

  Fly   117 SEYHELNDTHRWMQNLVGKYPDVVSVFVAGQSYEGRELLGLRINHNDGRAEKQSIFLEAGMHARE 181
            ..||.....:..|.::...:||:.|....|:::|.|.:..|:.:...|..::.:|:|.||:||||
  Rat   120 GSYHSPEAIYHEMDSIATDFPDLASRVKIGETFEKRPMYVLKFSTGGGGKKRPAIWLNAGIHARE 184

  Fly   182 WIGPATATYFANELLSSQQQE--IMNLARSYVWYILPHANPDGYVYTHKTNRMWRKTRSPQ-DKN 243
            ||..|||.:.|.::::..|::  :.::......::||.|||||||||...||:||||||.. ...
  Rat   185 WISQATAIWTARKIVTDYQKDPAVTSILEKMDIFLLPVANPDGYVYTQNQNRLWRKTRSRNPGSR 249

  Fly   244 CVGTDPNRNWDFHWREVGASSDPCSESYAGPKAFSEPEVQTLSQFLKSVPEPMFMFLSLHSFSQL 308
            |:|.||||||:..:...|||::||||.|.|....||.||:::..|::.... ...|:.|||:|||
  Rat   250 CIGADPNRNWNASFAGEGASNNPCSEVYHGSHPNSEVEVKSVVDFIQKHGN-FKCFIDLHSYSQL 313

  Fly   309 LLYPYGHTSALPENHRQLEQIFNTAVGAMKRRYGTRYTGGNVYDAIYPAAGSSMDWAYGVLNVKY 373
            |:||||::.....:..:|:.:..:|..|:....||:|..|.....:|||:|||:||||. ..:||
  Rat   314 LMYPYGYSVKKAPDAEELDDVARSAAKALASLSGTKYQVGPTCTTVYPASGSSVDWAYD-NGIKY 377

  Fly   374 SFTYELRPSGYSFWTGFRLPAAQIIPTGQETTDSL 408
            :||:|||.:|:   .||.|||:|||||.:||...|
  Rat   378 AFTFELRDTGH---YGFLLPASQIIPTAEETWQGL 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4017	NP_609309.1	Propep_M14	30..97	CDD:280416	19/75 (25%)
CG4017	NP_609309.1	M14_CP_A-B_like	119..415	CDD:199844	117/293 (40%)
Cpa4	NP_001102816.1	Propep_M14	28..99	CDD:280416	19/76 (25%)
Cpa4	NP_001102816.1	Peptidase_M14_like	117..419	CDD:299699	117/298 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351620
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm8990
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.750