DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4017 and CG18585

DIOPT Version :9

Sequence 1:	NP_609309.1	Gene:	CG4017 / 34296	FlyBaseID:	FBgn0032143	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001260213.1	Gene:	CG18585 / 34041	FlyBaseID:	FBgn0031929	Length:	422	Species:	Drosophila melanogaster

Alignment Length:	444	Identity:	159/444 - (35%)
Similarity:	252/444 - (56%)	Gaps:	46/444 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKLLLLLLSVNIL----IFCLAERQRFDNYKVYRVSPVKANQLEGLRSL-----------EANSE 50
            |:||.||.::..|    |...:.::|:||::||:::.....||..:..:           |.:..
  Fly     1 MRLLWLLATLVALTSAGILKDSPKERYDNFRVYKLTIQNKIQLAAIEKIGELTKKYNIWKEYDER 65

  Fly    51 DALVLNNLHLGPTDFLVAPDFDGTFLKLVKDLDLSPELIDANAQTSLSLD-IEPIADANRRSDDY 114
            ...:         |.:|:|.....|.:|:|..::|.||:..|.|..:..: :.|.||    |..:
  Fly    66 SRQI---------DIMVSPGELNHFQELLKFNNISSELMIENVQERIDEEQVTPTAD----SATF 117

  Fly   115 SWSEYHELNDTHRWMQNLVGKYPDVVSVFVAGQSYEGRELLGLRINHNDGRAEKQSIFLEAGMHA 179
            .|::|:||.:...|:..::..||.|...|:.|:|||||.:.|::|:|   :|....||:|:.:||
  Fly   118 GWTKYYELEEIEAWLDEILNAYPSVTEEFIVGKSYEGRTIRGIKISH---KAGNPGIFIESNIHA 179

  Fly   180 REWIGPATATYFANELLSSQQQEIMNLARSYVWYILPHANPDGYVYTHKTNRMWRKTRSPQDKN- 243
            ||||..|:||:|.|:||:|:..::.:||.:|.|:|:|..|.||:.|:||.:|||||||.|...|
  Fly   180 REWITSASATWFINQLLTSEDADVRSLADNYDWHIIPVFNVDGFEYSHKKDRMWRKTRQPHATNA 244

  Fly   244 CVGTDPNRNWDFHW-REVGASSDPCSESYAGPKAFSEPEVQTLSQFLKSVPEPMFMFLSLHSFSQ 307
            |:|.|.|||:|.:| :..|||.:||||::||....||||.:.|.::|..:.:.:.:::|.||:.|
  Fly   245 CIGADANRNFDSYWLQNNGASDNPCSETFAGDNPESEPEAKALVEYLTKIQDQISVYISFHSYGQ 309

  Fly   308 LLLYPYGHTS-ALPENHRQLEQI---FNTAVGAMKRRYGTRYTGGNVYDAIYPAAGSSMDWAYGV 368
            .||.|||||: ..|||:..:..|   |..|:.|:.  |||.|..|:..|.:|.|.|:|:||.:..
  Fly   310 YLLSPYGHTNEEFPENYNDILTIGKAFADAIEALP--YGTVYQYGSTADVLYVATGTSVDWVFNE 372

  Fly   369 LNVKYSFTYELRPSG-YSFWTGFRLPAAQIIPTGQETTDSLVEMIKAAAQIEGY 421
            |..|..:|.|.|..| |    ||.||..||||..:|....::.:|:...:: ||
  Fly   373 LGKKIGYTIEYRDKGRY----GFILPPVQIIPNCEELMVGMLALIEKTKEL-GY 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4017	NP_609309.1	Propep_M14	30..97	CDD:280416	14/77 (18%)
CG4017	NP_609309.1	M14_CP_A-B_like	119..415	CDD:199844	126/302 (42%)
CG18585	NP_001260213.1	Propep_M14	34..105	CDD:280416	14/79 (18%)
CG18585	NP_001260213.1	M14_CP_A-B_like	122..415	CDD:199844	126/301 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467034
Domainoid	1	1.000	158	1.000	Domainoid score	I1007
eggNOG	1	0.900	-	-		E1_COG2866
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I2114
Isobase	1	0.950	-	0	Normalized mean entropy	S1851
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm6559
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	P	PTHR11705
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1730
SonicParanoid	1	1.000	-	-		X86
	13	12.780