DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4017 and cpa1

DIOPT Version :9

Sequence 1:	NP_609309.1	Gene:	CG4017 / 34296	FlyBaseID:	FBgn0032143	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001018318.1	Gene:	cpa1 / 325886	ZFINID:	ZDB-GENE-050522-438	Length:	418	Species:	Danio rerio

Alignment Length:	437	Identity:	151/437 - (34%)
Similarity:	239/437 - (54%)	Gaps:	50/437 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKLLLLLLSVNILIFCLAERQRFDNYKVYRVSPVKANQLEGLRSLEANSEDALVLNNLHLGPTDF 65
            ||.||:|.::.:.:|   .:..|:..:|.|::...|.|:..|:  |....|.|.|        ||
Zfish     1 MKGLLVLTALFVAVF---GKVTFEGDQVLRINAKNAEQISLLK--ELTEADLLGL--------DF 52

  Fly    66 LVAPDFDGTFLKLVKDLDLSPELID------ANAQTSLSLDIEPIADA--------------NRR 110
            .:.|..:    .|..||.:....:.      |..|....:.||.:.|.              .|.
Zfish    53 WMNPARE----SLPVDLHVPFHSLQAVRAFLAYNQIPYHIMIENVQDLVDKEQLQMLKYHGFPRS 113

  Fly   111 SDDYSWSEYHELNDTHRWMQNLVGKYPDVVSVFVAGQSYEGRELLGLRINHNDGRAEKQSIFLEA 175
            :||:.::.||:|:..:.:|..||.:..::||....|||||.|.|..|:.:..   |.:..|:::.
Zfish   114 TDDFVYTTYHDLDSINLFMDMLVAENQNMVSKIEIGQSYENRPLNVLKFSTG---ANRPGIWIDT 175

  Fly   176 GMHAREWIGPATATYFANELLSSQQQE--IMNLARSYVWYILPHANPDGYVYTHKTNRMWRKTRS 238
            |:|:||||..|:..:||.::::...::  :.::..||..::...|||||..|||..:|||||||.
Zfish   176 GLHSREWITHASGIWFAKKIVTDYGRDPVLTDILNSYDIFLEIVANPDGLAYTHSDDRMWRKTRK 240

  Fly   239 PQ-DKNCVGTDPNRNWDFHWREVGASSDPCSESYAGPKAFSEPEVQTLSQFLKSVPEPMFMFLSL 302
            |. ..:|||.||||||:..:...|:||:|||::|.||...|||||:.:.:|:||... :..|||:
Zfish   241 PNPGSSCVGVDPNRNWETGFGGPGSSSNPCSQTYHGPSIHSEPEVKAIVEFVKSHGN-LKAFLSI 304

  Fly   303 HSFSQLLLYPYGHTSALPENHRQLEQIFNTAVGAMKRRYGTRYTGGNVYDAIYPAAGSSMDWAYG 367
            ||:||:||||||:|....::..:|.::...|...::..|.|.||.|::...||.|.|.:.||||
Zfish   305 HSYSQMLLYPYGYTQTAAKDQAELHELARKATSELQSLYNTAYTYGSIITTIYQADGVTTDWAY- 368

  Fly   368 VLNVKYSFTYELRPSG-YSFWTGFRLPAAQIIPTGQETTDSLVEMIK 413
            ...:|||:|:|||.:| |    ||.|||.||:||.:||..:|:.:::
Zfish   369 EQGIKYSYTFELRDTGRY----GFILPADQILPTAEETWLALMVIME 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4017	NP_609309.1	Propep_M14	30..97	CDD:280416	16/72 (22%)
CG4017	NP_609309.1	M14_CP_A-B_like	119..415	CDD:199844	121/299 (40%)
cpa1	NP_001018318.1	Propep_M14	27..99	CDD:280416	19/85 (22%)
cpa1	NP_001018318.1	Peptidase_M14_like	117..416	CDD:299699	121/304 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593531
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm6559
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.750