DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4017 and suro-1

DIOPT Version :9

Sequence 1:	NP_609309.1	Gene:	CG4017 / 34296	FlyBaseID:	FBgn0032143	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_492177.2	Gene:	suro-1 / 172557	WormBaseID:	WBGene00011235	Length:	664	Species:	Caenorhabditis elegans

Alignment Length:	486	Identity:	150/486 - (30%)
Similarity:	222/486 - (45%)	Gaps:	98/486 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLSVNILIF-----CLAE-RQRFDNYKVYRVSPVKANQLEGLRSLEANSEDALVLNNLHLGPTD 64
            :||:|:.::.     |..: ....|.|.:..||......|..::.|:.|               |
Worm     8 ILLAVHTILLVGSVCCSTDVHNTDDKYALIHVSAHDEQSLHLIKQLQLN---------------D 57

  Fly    65 FLVAPDF-------------------------------DGTFLKLVKDLDLSPELIDANAQT--- 95
            |....||                               :.|....|.|::   :||..|..|
Worm    58 FKYDLDFWKSPSSISDKADIMVKRGKSERMLRQILSFANVTVSMSVPDVE---KLIMRNEGTTSK 119

  Fly    96 ------SLS--------LDIEPIADANR----RSDDYSWSEYHELNDTHRWMQNLVGKYPDVVSV 142
                  |||        ||.||..|..:    :...|.:.:|....|..::|:.:...||.:..:
Worm   120 SHLGFGSLSKWLHDDPILDSEPDLDLTKVGALKKAKYPFGDYASYADMVKYMRTIEFYYPRIAKI 184

  Fly   143 FVAGQSYEGRELLGLRINHNDGRAEKQSIFLEAGMHAREWIGPATATYFANELLS--SQQQEIMN 205
            ...|.::||:.:.||:|...... :|::::::..:|||||....||.||.|:|:|  .:..:|.|
Worm   185 VRIGATHEGKPIEGLKIGARSSH-KKRAVWVDGNIHAREWASSHTALYFINQLVSEYGKDAQITN 248

  Fly   206 LARSYVWYILPHANPDGYVYTH----KTNRMWRKTRSPQ---------DKNCVGTDPNRNWDFHW 257
            ...:..:||:|..|||||.||.    .|.|:|||.|||:         :|.|.|.|.|||:.|||
Worm   249 YVDTLDFYIVPCLNPDGYEYTRTSPIPTVRLWRKNRSPELCRPSLWGGEKCCRGVDLNRNFRFHW 313

  Fly   258 REVGASSDPCSESYAGPKAFSEPEVQTLSQFLKSVPE---PMFMFLSLHSFSQLLLYPYGHTSA- 318
            .|.|:|.:|||..|.|.:.|||||.:.:..|| :.||   .:..|::|||::||.:|||.|...
Worm   314 AERGSSYEPCSNIYHGEEVFSEPETRAVRNFL-ATPEMKDRVDAFVTLHSYAQLWIYPYSHEEQN 377

  Fly   319 LPENHRQLEQIFNTAVGAMKRRYGTRYTGGNVYDAIYPAAGSSMDWAYGVLNVKYSFTYELRPSG 383
            .||:..:|.:....|:..:.|.|||.|..|...|.:.||||.|.|||...|||||.:..||||.
Worm   378 YPEDIGELRKTARKAINRLSRVYGTNYRMGTGADTLSPAAGGSDDWAKSALNVKYVYLIELRPQ- 441

  Fly   384 YSFWTGFRLPAAQIIPTGQETTDSLVEMIKA 414
            .....||.|...::|||..||.:...|::.|
Worm   442 MELSNGFILHKKELIPTAVETFEGFREVVDA 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4017	NP_609309.1	Propep_M14	30..97	CDD:280416	16/106 (15%)
CG4017	NP_609309.1	M14_CP_A-B_like	119..415	CDD:199844	119/315 (38%)
suro-1	NP_492177.2	Propep_M14	39..110	CDD:280416	12/88 (14%)
		M14_CP_A-B_like	161..473	CDD:199844	119/315 (38%)
		ShK	620..657	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I2114
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm4737
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.770