DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4017 and Y47G6A.19

DIOPT Version :9

Sequence 1:	NP_609309.1	Gene:	CG4017 / 34296	FlyBaseID:	FBgn0032143	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001379340.1	Gene:	Y47G6A.19 / 171921	WormBaseID:	WBGene00021645	Length:	509	Species:	Caenorhabditis elegans

Alignment Length:	447	Identity:	158/447 - (35%)
Similarity:	230/447 - (51%)	Gaps:	62/447 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLLLLLSVNILIFCLAERQRFDNYKVYRVSPVKANQ-LEGLRSLEANSEDAL-------VLNNLH 59
            :|.||::|:      :..|....:||:||.|....| |:.:|..|....|..       |:|
Worm     6 ILALLIAVH------SSCQEHGAFKVFRVLPTTNQQLLQMIRLFETADTDRADFWHAPSVVN--- 61

  Fly    60 LGPTDFLVAPDFDGTFLKLVKDL---------DLSPELIDANAQTSL-SLDIEPIADA---NRRS 111
             |..|.:|||:....|.:.::..         ||...||:.....|. |.|     ||   .|..
Worm    62 -GTVDIMVAPEHTDQFRQYLEKHGYTFQVAIDDLHKLLIEKEGNLSTHSND-----DAFFLKRLH 120

  Fly   112 DDYSW------SEYHELNDTHRWMQNLVGKYPDVVSVFVAGQSYEGRELLGLRINHNDGRAEKQS 170
            ||..:      .||:..:....|::.:....||:..:...|.:.|||::|||:...:  ..:|:.
Worm   121 DDVGFHSRLRMGEYYSYSVLSTWLERIAENMPDIAKLIKVGTTIEGRDILGLKFGKD--TPDKKI 183

  Fly   171 IFLEAGMHAREWIGPATATYFANELLSSQQQ--EIMNLARSYVWYILPHANPDGYVYTH--KTN- 230
            :.::||:|||||....||:||.|.:::.:::  :|.|...:.|.||:|..|||||.||.  |||
Worm   184 VVIDAGIHAREWAAIHTASYFINLIVNGREEDPQIQNYLDNIVLYIIPVLNPDGYEYTRTDKTNP 248

  Fly   231 --RMWRKTRSP--------QDKNCVGTDPNRNWDFHWREVGASSDPCSESYAGPKAFSEPEVQTL 285
              |||||:|||        ::..|:|.|.|||:||.:.|:|||..||||.|.||.||||||.:..
Worm   249 RARMWRKSRSPKACAFDGVRNSCCMGVDLNRNFDFRFSEIGASRYPCSEIYHGPSAFSEPESKAY 313

  Fly   286 SQFLKSVPEPMFMFLSLHSFSQLLLYPYGHTS-ALPENHRQLEQIFNTAVGAMKRRYGTRYTGGN 349
            ||||.|:...:..:::|||:|||.:|.|.|.. ....:..:..::...||..:.|.|||:|..|.
Worm   314 SQFLTSLKGRLEAYITLHSYSQLWIYSYSHRKFTYAPDIEETRRVAAKAVQELGRMYGTKYRHGT 378

  Fly   350 VYDAIYPAAGSSMDWAYGVLNVKYSFTYELRP--SGYSFWTGFRLPAAQIIPTGQET 404
            ..:.||..:|.|.|||...|.:|||:|.||||  .|...|.||.|...|:|||.:||
Worm   379 GPEIIYAFSGGSTDWAKETLKIKYSYTIELRPGYEGIIEWNGFVLDKNQLIPTAKET 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4017	NP_609309.1	Propep_M14	30..97	CDD:280416	20/83 (24%)
CG4017	NP_609309.1	M14_CP_A-B_like	119..415	CDD:199844	122/304 (40%)
Y47G6A.19	NP_001379340.1	Propep_M14	32..102	CDD:396700	17/73 (23%)
		M14_CP_A-B_like	134..446	CDD:349433	122/304 (40%)
		ShK	467..504	CDD:396228
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1851
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.780