DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4017 and T06A4.3

DIOPT Version :9

Sequence 1:	NP_609309.1	Gene:	CG4017 / 34296	FlyBaseID:	FBgn0032143	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001021611.1	Gene:	T06A4.3 / 171668	WormBaseID:	WBGene00020283	Length:	505	Species:	Caenorhabditis elegans

Alignment Length:	458	Identity:	148/458 - (32%)
Similarity:	227/458 - (49%)	Gaps:	88/458 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SVNILIF-CL-AERQRFDNYKVYRVSPVKANQLEGLRSLEANSEDALVLNNLHLGPT-------- 63
            :.::||| |. |......::.|||:.|......:.::.|..|:.|    ::|:...|
Worm     4 NTSLLIFLCFSAVSLSTQSFAVYRLLPKSQTDFQAIQRLYKNATD----HDLNFWKTGKDKHGFW 64

  Fly    64 -------------DFLVAPDFDGTFLKLVKDLD--------------LSPELIDANAQTSLSLDI 101
                         |||...|.  :::|.:.|::              :.|.|.|.:
Worm    65 DVMVDMKNSKYFLDFLQVNDI--SYIKTIDDVEGLITKHENNKTLSNMFPRLWDDS--------- 118

  Fly   102 EPIADANRRSDDYSWSEYHELNDTHRWMQNLVGKYPDVVSVFVAGQSYEGRELLGLRINHNDGRA 166
                 ::...|.:::..|..:.|   ||:.||.|||.:|.....|::.|||.:.|:.|. .|.|.
Worm   119 -----SSAHYDFHTYGSYQRMTD---WMKQLVVKYPKMVQYISIGKTTEGRNIDGVEIG-GDSRT 174

  Fly   167 EKQSIF-LEAGMHAREWIGPATATYFANELLS-SQQQEIMNLARSYVWYILPHANPDGYVYTH-K 228
            :|  || ::.|:|||||..|.||.:|.::|.| :.:..|..|.....:.::|..|||||.:|. .
Worm   175 KK--IFWIDGGIHAREWAAPHTALFFIHQLTSRANEPGIKKLLNEITFVVVPCLNPDGYEFTRSS 237

  Fly   229 TN---RMWRKTRSP---------QDKNCVGTDPNRNWDFHWREVGASSDPCSESYAGPKAFSEPE 281
            ||   |:|||.||.         :::.|.|.|.|||:|||:||.|.|.|||||.|.||..|||||
Worm   238 TNPHVRLWRKNRSKMQCRKDIWGRNRCCRGVDLNRNFDFHFRESGTSDDPCSEIYQGPSPFSEPE 302

  Fly   282 VQT-----LSQFLKSVPEPMFMFLSLHSFSQLLLYPYGH-TSALPENHRQLEQIFNTAVGAMKRR 340
            .:.     |||..|...:   .:::||::||:.::|||| ..|.|.:.:.|.::...|..|:||.
Worm   303 AKAVRDALLSQRYKGRTD---AYITLHTYSQIWIHPYGHKKDAYPGDIKDLYEVGKKAAQALKRV 364

  Fly   341 YGTRYTGGNVYDAIYPAAGSSMDWAYGVLNVKYSFTYELRPSGYSFWTGFRLPAAQIIPTGQETT 405
            |||:|..|:..|.:|||:|.|.|||.....||:.:..||||...: |.||.|...::|||.:||.
Worm   365 YGTKYVVGSGADTLYPASGGSEDWAKHEAKVKFVYLLELRPDEKN-WDGFILDEKELIPTARETW 428

  Fly   406 DSL 408
            :.:
Worm   429 EGV 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4017	NP_609309.1	Propep_M14	30..97	CDD:280416	16/101 (16%)
CG4017	NP_609309.1	M14_CP_A-B_like	119..415	CDD:199844	124/311 (40%)
T06A4.3	NP_001021611.1	Propep_M14	31..98	CDD:366995	11/72 (15%)
		M14_CP_A-B_like	128..438	CDD:349433	124/314 (39%)
		ShK	468..505	CDD:366702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I2114
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm4737
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.880