DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4017 and Y18H1A.9

DIOPT Version :9

Sequence 1:	NP_609309.1	Gene:	CG4017 / 34296	FlyBaseID:	FBgn0032143	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_490776.2	Gene:	Y18H1A.9 / 171666	WormBaseID:	WBGene00021213	Length:	488	Species:	Caenorhabditis elegans

Alignment Length:	466	Identity:	153/466 - (32%)
Similarity:	241/466 - (51%)	Gaps:	81/466 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VNILIF-------CLAERQRFDNYKVYRVSPVKANQLEGLRSLEANSEDALVLNNLHLGPT--DF 65
            :||::.       .||.:::|   .|:||.|...:|::             :|:||:|...  ||
Worm     1 MNIIVLIGLVVPSVLAHQKKF---TVWRVQPTTQDQVD-------------ILHNLYLNDVKLDF 49

  Fly    66 LVAPDFDGTFLKLV----KDLDLSPELIDANAQTSLSL-DIEPIADANRRSDD--------YSWS 117
            ..:|...|..:.::    |......||.|.:.:.|:.: |::.:....:...|        :.|.
Worm    50 WKSPSEAGKEVHVMISDEKTQQFMKELDDHSIKHSVMIDDVQKVIVEQKEKRDKLRKQVRLHDWR 114

  Fly   118 E---------YHELNDTHRWMQNLVGKYPDVVSVFVAGQSYEGRELLGLRINHNDGRAEKQSIFL 173
            |         ||...|...::.:|...||::|||...|.::|||::..::|.:......|:.|::
Worm   115 EQKVQFNLAQYHSFADVINYLNSLAITYPELVSVQPIGTTHEGRQIPLIKITNKRNGGTKRGIWV 179

  Fly   174 EAGMHAREWIGPATATYFANELLSSQQQEIMNLARSYV----WYILPHANPDGYVYTHKTN---- 230
            :.|:|||||:.|:|..||.::|::...:::.  .:.:|    |||:|..|||||.|:..:|
Worm   180 DGGIHAREWVSPSTVLYFIHQLVTQYDKDVQ--IKQFVDQLEWYIVPLLNPDGYEYSRSSNDPEI 242

  Fly   231 RMWRKTRSP----QDKN----------CVGTDPNRNWDFHWREVGASSDPCSESYAGPKAFSEPE 281
            |:|||.|||    |...          |.|.|.|||:|:.:.:||:|:|||||.|.|..||||||
Worm   243 RLWRKNRSPPKCIQQATGLFQPPTTTCCQGVDLNRNFDWFFGQVGSSTDPCSEIYQGAYAFSEPE 307

  Fly   282 VQTLSQFLKSVPEPMFMFLSLHSFSQLLLYPYGHTSALPENHRQLEQIFNTAVG---AMKRRYGT 343
            ...:..|::.  ..:..||:.||:||:|:||:||......|  .|..:.:||:.   |:...|.|
Worm   308 TAAVRDFVQR--HRISTFLTFHSYSQILMYPFGHQVRTYSN--DLNDLRSTALSAAQALNSVYNT 368

  Fly   344 RYTGGNVYDAIYPAAGSSMDWAYGVLNVKYSFTYELRPSGYSFWTGFRLPAAQIIPTGQETTDSL 408
            :|..|...|.:|||:|.|.|||.|..:|||||.:||||. ...|.||.|...|||||.:||.::
Worm   369 QYKVGTGADTLYPASGGSEDWAKGKAHVKYSFLFELRPE-EQVWDGFLLAENQIIPTARETWEA- 431

  Fly   409 VEMIKAAAQIE 419
            |::| |:..||
Worm   432 VKVI-ASKTIE 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4017	NP_609309.1	Propep_M14	30..97	CDD:280416	16/72 (22%)
CG4017	NP_609309.1	M14_CP_A-B_like	119..415	CDD:199844	123/320 (38%)
Y18H1A.9	NP_490776.2	Propep_M14	29..97	CDD:366995	15/80 (19%)
		M14_CP_A-B_like	125..436	CDD:349433	123/319 (39%)
		ShKT	454..487	CDD:214586
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I2114
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm4737
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1730
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.810