Protein Alignment ppk18 and ASIC5

DIOPT Version :10

• Sequence 1: NP_609308.3
• Gene: ppk18 / 34295
• FlyBaseID: FBgn0265001
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_059115.1
• Gene: ASIC5 / 51802
• HGNCID: 17537
• Length: 505
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 112/572 - (19%)
• Similarity: 185/572 - (32%)
• Gaps: 160/572 - (27%)

  Fly    10 RRLFREFLRQSYINGLHPFLYHTPVRYAKAIWL-AFLTAIMIYTHIVIADLILEYLVQPTEIHMA 73
            ::...:|...:..:|:|..:.:.. :..:.:|| ..|.::.:.|..:...| |.|...||...:
Human    35 KKFDHDFAISTSFHGIHNIVQNRS-KIRRVLWLVVVLGSVSLVTWQIYIRL-LNYFTWPTTTSI- 96

  Fly    74 PDLVHVANSPFPAVGVCTSNKINGRLLRSY---------AEKLFHHQGNSSLQAVALDLDDMANR 129
             ::.:|....||||..|..|:.....:..:         ..|:.|.|..::....:.:..|.|
Human    97 -EVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFA-- 158

  Fly   130 LLVLAQFYLNPLESDHERWNATELDRLHRLLVAYHNGAGYSVRDILRDLSPGCGDLVIRGIVFGL 194
                         :.|:.::..|..|         |...|.....|.|..           .||.
Human   159 -------------ASHQNFSIVEFIR---------NKGFYLNNSTLLDCE-----------FFGK 190

  Fly   195 PVNASQLFLKRPTSSNVCCIFNYRRPSYSQFLTKRAEEDSEMRAVPMV------VFESNSILNSV 253
            |.:... |....|....|..||     :.:.|..:.:.....|.:.::      .|..|..|..|
Human   191 PCSPKD-FAHVFTEYGNCFTFN-----HGETLQAKRKVSVSGRGLSLLFNVNQEAFTDNPALGFV 249

  Fly   254 Q----FVLQDTPKEDITNTFHSNSAFQLIIFPQEDYATIQS-------TTLGEVLVDHYSIVEIP 307
            .    ||:. :||:                .||.|...:.|       .|:.:|...|..
Human   250 DAGIIFVIH-SPKK----------------VPQFDGLGLLSPVGMHARVTIRQVKTVHQE----- 292

  Fly   308 IQPMFFSSGDGVRGVPPHIRRCYYP----EEGMRLLNQSYYSLDECLLVCRMKSMIDHCGCVSPP 368
                                   ||    ...::|.|.|.||...||..|:.:.:...||||...
Human   293 -----------------------YPWGECNPNIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFL 334

  Fly   369 LTGSSMDLDY-----CMLPDLPCLMRWKSIWYGYSDFAYLQNKEENLVQRQCEHCLPTCNGVSMS 428
            |.|..::.|.     |:.|.|.                :::.|:...|......|..:|..:...
Human   335 LPGYGIECDLQKYFSCVSPVLD----------------HIEFKDLCTVGTHNSSCPVSCEEIEYP 383

  Fly   429 ITTNVAPLRRTYNSSGYFTGLLKGLTNERP-----LAIIKLFFKLRFAQATKSQMVSSWVVLLNR 488
            .|.:.:    ::.|......|.|.|...|.     |..|::.:.....:.|:.|...|...||..
Human   384 ATISYS----SFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLAD 444

  Fly   489 FGGILSLMYGFSIVSYIEILYYLTGKGFVYIYRSFLL--------DKEPINH 532
            .||.|.|..|.|:::.|||:.||. ..|.:|...|||        ...|.||
Human   445 LGGQLGLFCGASLITIIEIIEYLF-TNFYWICIFFLLKISEMTQWTPPPQNH 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk18	NP_609308.3	ASC	16..510	CDD:459966	102/534 (19%)
ASIC5	NP_059115.1	Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000250|UniProtKB:Q9R0W5	1..30
		ASC	41..466	CDD:459966	102/534 (19%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	454..456		1/1 (100%)