Protein Alignment ppk18 and asic4a

DIOPT Version :10

• Sequence 1: NP_609308.3
• Gene: ppk18 / 34295
• FlyBaseID: FBgn0265001
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_999952.1
• Gene: asic4a / 407668
• ZFINID: ZDB-GENE-040513-5
• Length: 539
• Species: Danio rerio
• Alignment Length: 596
• Identity: 107/596 - (17%)
• Similarity: 188/596 - (31%)
• Gaps: 217/596 - (36%)

  Fly    16 FLRQSYINGLHPFLYHTPVRYAKAIW-LAFLTAIMIYTHIVIADLILEYLVQP--TEIH--MAPD 75
            |...|.::|::.......:...:.:| ||||.::.::.: ..|...:.||..|  |.::  ..|:
Zfish    44 FASASSLHGINHIFVSGRLGVRQTLWALAFLVSLALFLY-QAAKCAISYLEHPHVTALNEEATPE 107

  Fly    76 LVHVANSPFPAVGVCTSNKINGRLLRSYAEKLFHHQGN--------------SSLQAVALDLDDM 126
            :|      ||||.:|..|:..   ..:..:...:|..|              :.|:..|.|:.|:
Zfish   108 MV------FPAVTICNINRFR---FSALTDADIYHLANLTGLPPKNKDGHKPTDLEYPAPDMQDI 163

  Fly   127 ANRLLVLAQFYLNPLESDHERWNATELDRLHRLLVAYH-NGAGYSVRDILRDLSPGCGDLVIRGI 190
            .||             :.|:         |..:|.:.: :|...|..|..              :
Zfish   164 FNR-------------TGHQ---------LEEMLKSCNFSGQNCSAEDFT--------------V 192

  Fly   191 VFGLPVNASQLFLKRPTSSNVCCIFNYRRPSYSQFLTKRAEEDSEMRAVPMVVFESNSILNSVQF 255
            |:              |....|..||..:      .|.|..:...|.             |.::.
Zfish   193 VY--------------TRYGKCYTFNGNK------TTSRKTKQGGMG-------------NGLEI 224

  Fly   256 VLQDTPKEDITNTFHSNSAFQLIIFPQEDYATIQSTTLGEVLVDHYSIVEIPIQPMFFSSGDGVR 320
            :|      ||               .|:||..|...|       :.:.:|..|:....|..:
Zfish   225 ML------DI---------------QQDDYLPIWKET-------NETSLEAGIRVQIHSQDE--- 258

  Fly   321 GVPPHIRRCYY------------PEEGMRLLNQSY----------------YSLDECLLVCRMKS 357
              ||:|.:..:            .|:.:..|.|.:                ||:..|.|.|....
Zfish   259 --PPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRSTSEQMIPGYDTYSISACRLRCETLE 321

  Fly   358 MIDHCGCVSPPLTGSSMDLDYCMLPDLPCLMRWKSIWYGYSDFAYLQNKEENLVQRQ----CEHC 418
            ::..|.|....:.|   |.:.|...|:.|:                 :|...|:|:.    | .|
Zfish   322 VLRECKCRMVHMPG---DANICTPSDIKCV-----------------DKALALLQKSSGDTC-FC 365

  Fly   419 LPTCN----GVSMSITT-----NVAPLRRTYNSSGYFTGLLKGLTNERPLAIIKLFFKLRFAQAT 474
            ...||    |..:|:..     :...|.|.|:.|..:.        .....::.:||:....:..
Zfish   366 ETPCNLTRYGKELSMVKIPSKGSARYLSRKYDKSEDYI--------RDNFLVLDIFFEALNYETI 422

  Fly   475 KSQMVSSWVVLLNRFGGILSLMYGFSIVSYIEILYYLTGKGFVYIYRSFLLDKEPINHNYSLYWR 539
            :.:.......||...||.:.|..|.|:::.:|||.|      ||         |.|.|......|
Zfish   423 EQKKAYDVAGLLGDIGGQMGLFIGASVLTILEILDY------VY---------EVIKHRLERLLR 472

  Fly   540 ELRSNLPRQEQ 550
            ..|.:..:.:|
Zfish   473 PQRDDKKQTQQ 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk18	NP_609308.3	ASC	16..510	CDD:459966	98/554 (18%)
asic4a	NP_999952.1	ENaC	44..472	CDD:273304	104/583 (18%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	446..448		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	474..494		2/10 (20%)