DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment und and Metap1

DIOPT Version :9

Sequence 1:	NP_001260299.1	Gene:	und / 34294	FlyBaseID:	FBgn0283478	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_780433.1	Gene:	Metap1 / 75624	MGIID:	1922874	Length:	386	Species:	Mus musculus

Alignment Length:	425	Identity:	81/425 - (19%)
Similarity:	127/425 - (29%)	Gaps:	153/425 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 KKKGNKGKK---------SGQTDP-----------PTIPIAKLYPDGNFPEGEIVEHPTPKDMPD 112
            |.|..|.|:         ...|||           |..|:....|..::     ::.|...|.|
Mouse    54 KAKDEKAKREVCSWTVEGDVNTDPWAGYRYTGKLRPHYPLMPTRPVPSY-----IQRPDYADHP- 112

  Fly   113 DRTAKDRFTSEEKRAL------DRINTDIYQELRQAAEAHRQTRQYMQRYIKPGMTMIQICEELE 171
                  ...||.::||      ..::::..:.:|......|:........||.|:|    .||::
Mouse   113 ------LGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDIAAGMIKAGVT----TEEID 167

  Fly   172 NTAR-RLIGENGLEAGL---AFPTGC--SLNHCAAHYTPNAGDPTVLQYDDVCKIDF-----GTH 225
            :... ..|..|...:.|   .||..|  |:|....|..|   |...||..|:..:|.     |.|
Mouse   168 HAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIP---DRRPLQEGDIVNVDITLYRNGYH 229

  Fly   226 IKGRIIDCAFTLTFNNKYDKLLQAVKEATNTGIREAGIDVRLCDIGAAIQEVMESYEIELDGKTY 290
              |.:.:..|....:....||:|...|.....|......||..::|..||:     ..:.:|
Mouse   230 --GDLNETFFVGDVDEGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQK-----HAQANG--- 284

  Fly   291 PIKAIRNLNGHSISPYRIHAGKTVPIVKGGESTRMEEDEFYAIETFGSTGRGLVHDDMDCSHYMK 355
             ...:|:..||.|... .|....||                                    ||.|
Mouse   285 -FSVVRSYCGHGIHKL-FHTAPNVP------------------------------------HYAK 311

  Fly   356 NFDLPFVPLRLQSSKQLLGTINKNFGTL----------AFCK-RWLDRAGATKYQMALKDLCDKG 409
                                 ||..|.:          ..|: .|.|......:....:|
Mouse   312 ---------------------NKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRD----- 350

  Fly   410 IVEAYPPLCDIKGCYTAQYEHTIMLRPTCKEVVSR 444
                        |..:||:|||:::..|..|:::|
Mouse   351 ------------GKRSAQFEHTLLVTDTGCEILTR 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
und	NP_001260299.1	PTZ00053	<79..448	CDD:240246	77/405 (19%)
Metap1	NP_780433.1	Zinc finger-like, important for proper ribosome association. /evidence=ECO:0000255\|HAMAP-Rule:MF_03174	9..52
Metap1	NP_780433.1	APP_MetAP	14..382	CDD:320876	81/425 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810