DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment und and PA2G4

DIOPT Version :9

Sequence 1:	NP_001260299.1	Gene:	und / 34294	FlyBaseID:	FBgn0283478	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_006182.2	Gene:	PA2G4 / 5036	HGNCID:	8550	Length:	394	Species:	Homo sapiens

Alignment Length:	352	Identity:	79/352 - (22%)
Similarity:	147/352 - (41%)	Gaps:	51/352 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 KDMPDDRT-AKDRFTSEEKRALDRINTDIYQELRQAAEAHRQTRQYMQRYIKPGMTMIQICEE-- 169
            :|...::| |:|...::.|...|..|    :.||...||.           ..|::::.:||:
Human     4 EDEQQEQTIAEDLVVTKYKMGGDIAN----RVLRSLVEAS-----------SSGVSVLSLCEKGD 53

  Fly   170 ---LENTARRLIGENGLEAGLAFPTGCSLNHCAAHYTPNAGDPT-VLQYDDVCKIDFGTHIKGRI 230
               :|.|.:....|..::.|:||||..|:|:|..|::|...|.. :|:..|:.|||.|.|:.|.|
Human    54 AMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFI 118

  Fly   231 IDCAFTLTFNNKYDKLLQAVKEATNTGIREAGI----------DVRLCDIGAAIQEVMESYEIEL 285
            .:.|.|...:         |.:.|....|:|.:          .:||...|....:|.|::  ..
Human   119 ANVAHTFVVD---------VAQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAW--NK 172

  Fly   286 DGKTYPIKAIRNLNGHSISPYRIHAGKTV---PI---VKGGESTRMEEDEFYAIETFGSTGRGLV 344
            ...::....|..:..|.:..:.|...||:   |.   .|..|....|..|.||::...|:|.|..
Human   173 VAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKA 237

  Fly   345 HDDMDCSHYMKNFDLPFVPLRLQSSKQLLGTINKNFGTLAFCKRWLDRAGATKYQMALKDLCDKG 409
            .|....:...|........|::::|:.....:.:.|..:.|..|..:  ...|.:|.:.:.....
Human   238 KDAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFE--DEKKARMGVVECAKHE 300

  Fly   410 IVEAYPPLCDIKGCYTAQYEHTIMLRP 436
            :::.:..|.:.:|.:.||::.|::|.|
Human   301 LLQPFNVLYEKEGEFVAQFKFTVLLMP 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
und	NP_001260299.1	PTZ00053	<79..448	CDD:240246	79/352 (22%)
PA2G4	NP_006182.2	crvDNA_42K	1..388	CDD:273105	79/352 (22%)
		RNA-binding. /evidence=ECO:0000269\|PubMed:15064750	46..54		2/7 (29%)
		Necessary for nucleolar localization. /evidence=ECO:0000269\|PubMed:15064750	301..394		7/27 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..394
		Interaction with RNA. /evidence=ECO:0000250\|UniProtKB:P50580	361..375
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810