DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment und and fma2

DIOPT Version :9

Sequence 1:	NP_001260299.1	Gene:	und / 34294	FlyBaseID:	FBgn0283478	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_595906.1	Gene:	fma2 / 2539692	PomBaseID:	SPBC14C8.03	Length:	426	Species:	Schizosaccharomyces pombe

Alignment Length:	453	Identity:	247/453 - (54%)
Similarity:	320/453 - (70%)	Gaps:	35/453 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SATETLNVEAATPEIGEEVK-KQKKPKPNNKKLRQEAAAKIASGEGGDEELTTNGDAKPATPAAQ 65
            |||.|   ||...::.|::. |:.....::.|:.:..||         ||..:||:.|      :
pombe     3 SATTT---EATAKDLQEKLSLKENDVVEDDGKVEENDAA---------EEGASNGEKK------K 49

  Fly    66 PAKKKGNKGKKS--GQTDPPTIPIAKLYPDGNFPEGEIVEHPTPKDMPDDRTAKD---RFTSEEK 125
            ..|||.:|.||:  .||:|||:.::|::.:..:|.||:.::           |:|   |.|.|||
pombe    50 KKKKKSSKKKKTPQEQTNPPTVGLSKIFVNKKYPVGEVCDY-----------AEDNLWRTTDEEK 103

  Fly   126 RALDRINTDIYQELRQAAEAHRQTRQYMQRYIKPGMTMIQICEELENTARRLIGENGLEAGLAFP 190
            |||||.|.|.|.:||:|||.|||.|||.|..|||||:|:.:...:|||.|.|:.|:||::|:.||
pombe   104 RALDRQNFDQYNDLRRAAEVHRQARQYAQSVIKPGMSMMDVVNTIENTTRALVEEDGLKSGIGFP 168

  Fly   191 TGCSLNHCAAHYTPNAGDPTVLQYDDVCKIDFGTHIKGRIIDCAFTLTFNNKYDKLLQAVKEATN 255
            ||.|||||||||||||||.|:|:..||.|:|.|.|:.|||:|.|||::|:.:||.||.|||.|||
pombe   169 TGVSLNHCAAHYTPNAGDTTILKEKDVMKVDIGVHVNGRIVDSAFTMSFDPQYDNLLAAVKAATN 233

  Fly   256 TGIREAGIDVRLCDIGAAIQEVMESYEIELDGKTYPIKAIRNLNGHSISPYRIHAGKTVPIVKGG 320
            .||.|||||.||.:||.||||||||||:|::|||:.:|:||||.||::.||.||.||:|||||||
pombe   234 KGIEEAGIDARLNEIGEAIQEVMESYEVEINGKTHQVKSIRNLCGHNLDPYIIHGGKSVPIVKGG 298

  Fly   321 ESTRMEEDEFYAIETFGSTGRGLVHDDMDCSHYMKNFDLPFVPLRLQSSKQLLGTINKNFGTLAF 385
            |..:|||.|.:|||||||||||:||:||:||||.|..|...:||||..:|.||.||.:|||||.|
pombe   299 EEIKMEEGEIFAIETFGSTGRGVVHEDMECSHYAKIPDAGHIPLRLPRAKALLNTITQNFGTLPF 363

  Fly   386 CKRWLDRAGATKYQMALKDLCDKGIVEAYPPLCDIKGCYTAQYEHTIMLRPTCKEVVSRGDDY 448
            |:|:|||.|.:||.:||.:|...|||:.|||||||:|.||||:||||:|.||.||||||||||
pombe   364 CRRYLDRIGESKYLLALNNLVSAGIVQDYPPLCDIRGSYTAQFEHTIILHPTQKEVVSRGDDY 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
und	NP_001260299.1	PTZ00053	<79..448	CDD:240246	223/371 (60%)
fma2	NP_595906.1	PTZ00053	12..426	CDD:240246	239/439 (54%)
fma2	NP_595906.1	MetAP2	114..422	CDD:238521	196/307 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	404	1.000	Domainoid score	I100
eggNOG	1	0.900	-	-		E1_COG0024
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4981
Inparanoid	1	1.050	475	1.000	Inparanoid score	I270
OMA	1	1.010	-	-		QHG54020
OrthoFinder	1	1.000	-	-		FOG0003371
OrthoInspector	1	1.000	-	-		oto101624
orthoMCL	1	0.900	-	-		OOG6_100815
Panther	1	1.100	-	-	LDO	PTHR45777
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R57
SonicParanoid	1	1.000	-	-		X2266
TreeFam	1	0.960	-	-
	14	13.860