Protein Alignment und and METAP1

DIOPT Version :10

• Sequence 1: NP_477373.1
• Gene: und / 34294
• FlyBaseID: FBgn0283478
• Length: 448
• Species: Drosophila melanogaster
• Sequence 2: NP_055958.2
• Gene: METAP1 / 23173
• HGNCID: 15789
• Length: 386
• Species: Homo sapiens
• Alignment Length: 461
• Identity: 89/461 - (19%)
• Similarity: 138/461 - (29%)
• Gaps: 185/461 - (40%)

  Fly    30 NKKLRQEAAAKIASGEGGDEELTTNGDAKPATPAAQPAKKKGNKGKKSGQTDP-----------P 83
            :||.:.|.|.:..|      ..|..||.                     .|||           |
Human    52 HKKAKDEKAKREVS------SWTVEGDI---------------------NTDPWAGYRYTGKLRP 89

  Fly    84 TIPIAKLYPDGNFPEGEIVEHPTPKDMPDDRTAKDRFTSEEKRAL------DRINTDIYQELRQA 142
            ..|:....|..::     ::.|...|.|       ...||.::||      ..::::..:.:|..
Human    90 HYPLMPTRPVPSY-----IQRPDYADHP-------LGMSESEQALKGTSQIKLLSSEDIEGMRLV 142

  Fly   143 AEAHRQTRQYMQRYIKPGMTMIQICEELENTAR-RLIGENGLEAGL---AFPTGC--SLNHCAAH 201
            ....|:........||||:|    .||:::... ..|..|...:.|   .||..|  |:|....|
Human   143 CRLAREVLDVAAGMIKPGVT----TEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICH 203

  Fly   202 YTPNAGDPTVLQYDDVCKIDF-----GTH-------IKGRIIDCAFTLTFNNKYDKLLQAVKEAT 254
            ..|   |...||..|:..:|.     |.|       ..|.:.|.|..|. ...|:.|:||: :|.
Human   204 GIP---DRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLV-QTTYECLMQAI-DAV 263

  Fly   255 NTGIREAGIDVRLCDIGAAIQEVMESYEIELDGKTYPIKAIRNLNGHSISPYRIHAGKTVPIVKG 319
            ..|       ||..::|..||:     ..:.:|    ...:|:..||.|... .|....||
Human   264 KPG-------VRYRELGNIIQK-----HAQANG----FSVVRSYCGHGIHKL-FHTAPNVP---- 307

  Fly   320 GESTRMEEDEFYAIETFGSTGRGLVHDDMDCSHYMKNFDLPFVPLRLQSSKQLLGTINKNFGTL- 383
                                            ||.|                     ||..|.:
Human   308 --------------------------------HYAK---------------------NKAVGVMK 319

  Fly   384 ---------AFCK-RWLDRAGATKYQMALKDLCDKGIVEAYPPLCDIKGCYTAQYEHTIMLRPTC 438
                     ..|: .|.|......:....:|                 |..:||:|||:::..|.
Human   320 SGHVFTIEPMICEGGWQDETWPDGWTAVTRD-----------------GKRSAQFEHTLLVTDTG 367

  Fly   439 KEVVSR 444
            .|:::|
Human   368 CEILTR 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
und	NP_477373.1	PTZ00053	<79..448	CDD:240246	81/412 (20%)
METAP1	NP_055958.2	APP_MetAP	14..382	CDD:469704	89/461 (19%)