DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment und and METAP2

DIOPT Version :9

Sequence 1:	NP_001260299.1	Gene:	und / 34294	FlyBaseID:	FBgn0283478	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_006829.1	Gene:	METAP2 / 10988	HGNCID:	16672	Length:	478	Species:	Homo sapiens

Alignment Length:	459	Identity:	297/459 - (64%)
Similarity:	355/459 - (77%)	Gaps:	29/459 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AATPEIGEEVKKQKKPK-----------PNNKK-------LRQEAAAKIASGEGGDEELTTNGDA 57
            |:|.|...:.|::||.|           |:.:.       .||...:.:...|..:::...:||.
Human    28 ASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDG 92

  Fly    58 KPATPAAQPAKKKGNKGKKSG---QTDPPTIPIAKLYPDGNFPEGEIVEHPTPKDMPDDRTAKDR 119
            ..||     .|||..|.||.|   |||||::||..|||:|.||:|:..|:|..:   |.|||..|
Human    93 DGAT-----GKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQ---DGRTAAWR 149

  Fly   120 FTSEEKRALDRINTDIYQELRQAAEAHRQTRQYMQRYIKPGMTMIQICEELENTARRLIGENGLE 184
            .|||||:|||:.:.:|:.:.|:|||||||.|:|:..:||||||||:|||:||:.:|:||.||||.
Human   150 TTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLN 214

  Fly   185 AGLAFPTGCSLNHCAAHYTPNAGDPTVLQYDDVCKIDFGTHIKGRIIDCAFTLTFNNKYDKLLQA 249
            ||||||||||||:|||||||||||.|||||||:|||||||||.|||||||||:|||.|||.||:|
Human   215 AGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKA 279

  Fly   250 VKEATNTGIREAGIDVRLCDIGAAIQEVMESYEIELDGKTYPIKAIRNLNGHSISPYRIHAGKTV 314
            ||:||||||:.|||||||||:|.||||||||||:|:|||||.:|.|||||||||..|||||||||
Human   280 VKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTV 344

  Fly   315 PIVKGGESTRMEEDEFYAIETFGSTGRGLVHDDMDCSHYMKNFDLPFVPLRLQSSKQLLGTINKN 379
            |||||||:|||||.|.||||||||||:|:|||||:|||||||||:..||:||..:|.||..||:|
Human   345 PIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINEN 409

  Fly   380 FGTLAFCKRWLDRAGATKYQMALKDLCDKGIVEAYPPLCDIKGCYTAQYEHTIMLRPTCKEVVSR 444
            |||||||:|||||.|.:||.||||:|||.|||:.|||||||||.||||:||||:|||||||||||
Human   410 FGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSR 474

  Fly   445 GDDY 448
            ||||
Human   475 GDDY 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
und	NP_001260299.1	PTZ00053	<79..448	CDD:240246	273/368 (74%)
METAP2	NP_006829.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..123		29/99 (29%)
METAP2	NP_006829.1	PTZ00053	<107..478	CDD:240246	274/373 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	493	1.000	Domainoid score	I363
eggNOG	1	0.900	-	-		E1_COG0024
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4981
Inparanoid	1	1.050	594	1.000	Inparanoid score	I979
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54020
OrthoDB	1	1.010	-	-		D247763at33208
OrthoFinder	1	1.000	-	-		FOG0003371
OrthoInspector	1	1.000	-	-		oto90674
orthoMCL	1	0.900	-	-		OOG6_100815
Panther	1	1.100	-	-	LDO	PTHR45777
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R57
SonicParanoid	1	1.000	-	-		X2266
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870