DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zf30C and Zfp788

DIOPT Version :9

Sequence 1:	NP_477301.1	Gene:	zf30C / 34292	FlyBaseID:	FBgn0270924	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_001347603.1	Gene:	Zfp788 / 67607	MGIID:	1914857	Length:	884	Species:	Mus musculus

Alignment Length:	691	Identity:	156/691 - (22%)
Similarity:	242/691 - (35%)	Gaps:	160/691 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 CPVCNKALVSLAGYVKHVKKHQPPGGFECRHCDARFCHEEELTQHAKDEHGVTGAVAGQERKPFV 97
            |..|||..:.......|::.|.....:||:.|...|.......:|.|...|         .||:.
Mouse   296 CHYCNKVFICQGSLQSHIRVHTGEKPYECKQCGKAFRVNSSFWRHKKVHTG---------EKPYE 351

  Fly    98 CEKCGAEYKYQEAYRRHCRTKCGEEKLPREESRPMECKCCYTRFSSASNLSKHRRS----RPDTC 158
            |::||..:.|....:.|.||...|        :|..||.|...|.|.|:|..|.|:    :|..|
Mouse   352 CKQCGKSFIYPSLLQTHERTHSAE--------KPYSCKQCGKAFKSHSSLRVHERNHTGKKPYEC 408

  Fly   159 GQ--PEYDSP-------GSSDGMKKH------KAFRKKDRNRDSDDEDTTSEESEDSDDDIPLAS 208
            .|  ..:..|       .:..|:|.:      ||||:....|..:...|..:..|.........:
Mouse   409 KQCGRSFIYPCLLQIHERTHSGVKPYGCKQCGKAFRRLSDLRVHERTHTGEKPYECKQCAKSFIN 473

  Fly   209 RLKTKLKQESQNSDSGDECPDFEPNNSEDDADASGFQLPPPAMVKVEAFDEEDFEYQDASMYVKT 273
            |...|:.|:|...:...:|          ...:..|..|
Mouse   474 RYLLKMHQKSHTGEKPYKC----------KICSKAFVYP-------------------------- 502

  Fly   274 ESTDIFSNEKDKLLDVLLNEGDGLKPFESLKVEQGAGILDEIAAVP-LVEVAEEDVLELRGHQME 337
                       .||.:......|.||:...:       .|:....| |:::.|      |.|..|
Mouse   503 -----------SLLKLHERSHTGEKPYPCKQ-------CDKAFIFPSLLKLHE------RTHTGE 543

  Fly   338 KPPGPRKRGRPPKEKIPVVKRKYRKRNAPRSPSPDDSSGTPKRVAKISKKELKERLKMINKMEKS 402
            ||...::.|           ..::..|:                        .:|.|.|:...|:
Mouse   544 KPYACKQCG-----------EAFKSYNS------------------------LQRHKRIHTDVKA 573

  Fly   403 WKCPHCVKIYHIRKPYEKHLRDDHKLNEAEMKEIFKDVDVHAKLD--------EEVFKCPICSKI 459
            :.|.||.|.:..::..:.|.|........:.::.......|..|.        :.:::|..|.:.
Mouse   574 YVCKHCSKAFICQRSLQLHNRTHTGEKPYKCEQCGNSFRYHNSLQRHKIIHTGKNLYECKQCDRS 638

  Fly   460 YLVEKRLVTHMKVHGEDGKLTFKCPCYCNLFFATKEQATEHARAQHKELLY-CEKCDKYMTGHDS 523
            ::....|..|.:.|  .|...::| ..|...:........|.|....|..| |::|.|....|.|
Mouse   639 FIYPYLLQIHDRTH--SGGKPYEC-TQCGKSYIYPSLLRIHERTHSAEKPYSCKQCGKAFKSHSS 700

  Fly   524 LKNHERNFHSKKEPRSQQRNLICDKCGKKFTGRTSLSDHVRSDCGRLPLYGCSVCGKHLSTAGIL 588
            |:.|||| |:.::|..      |.:||:.|.....|..|.|...|..| |.|..|||........
Mouse   701 LRVHERN-HTGEKPYE------CKQCGRSFIYPCLLQTHERIHSGVKP-YECKQCGKAFRGHSSF 757

  Fly   589 KTHMLLHKADTPYQCDKCGKTFKVKAQYKSHLKTRHTDYKPYKCHLCPKEYPYRESLLTHMTVHT 653
            :.|..||..:.||:|.:|||.|...:..:.|.:| |:..|||.|..|.|.:..|.||..|...|.
Mouse   758 RVHKKLHSGEKPYECKQCGKCFIYPSLLRMHERT-HSSEKPYDCKQCGKAFKSRSSLREHERNHI 821

  Fly   654 GIKRFLCNNCGKRFTCISNLQAHRKVHA-------DTCGQL 687
            ..|.:.|..|||.|...|:.|.|:::||       ..||::
Mouse   822 EEKSYQCQQCGKIFRRYSSFQNHKQIHAIQKLNECKQCGKI 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zf30C	NP_477301.1	C2H2 Zn finger	33..53	CDD:275368	5/19 (26%)
		C2H2 Zn finger	61..82	CDD:275368	5/20 (25%)
		C2H2 Zn finger	98..117	CDD:275368	5/18 (28%)
		C2H2 Zn finger	134..152	CDD:275368	8/17 (47%)
		C2H2 Zn finger	511..532	CDD:275370	10/20 (50%)
		COG5048	<523..>672	CDD:227381	52/148 (35%)
		C2H2 Zn finger	546..566	CDD:275368	7/19 (37%)
		C2H2 Zn finger	575..595	CDD:275368	5/19 (26%)
		C2H2 Zn finger	603..624	CDD:275368	7/20 (35%)
		C2H2 Zn finger	632..652	CDD:275368	7/19 (37%)
		C2H2 Zn finger	660..680	CDD:275368	8/19 (42%)
Zfp788	NP_001347603.1	KRAB	23..64	CDD:307490
		C2H2 Zn finger	240..260	CDD:275368
		C2H2 Zn finger	268..288	CDD:275368
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		zf-H2C2_2	308..332	CDD:316026	5/23 (22%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		zf-H2C2_2	336..361	CDD:316026	8/33 (24%)
		C2H2 Zn finger	352..372	CDD:275368	6/19 (32%)
		C2H2 Zn finger	380..400	CDD:275368	9/19 (47%)
		C2H2 Zn finger	408..428	CDD:275368	3/19 (16%)
		C2H2 Zn finger	436..456	CDD:275368	5/19 (26%)
		C2H2 Zn finger	464..484	CDD:275368	3/19 (16%)
		COG5048	488..883	CDD:227381	106/482 (22%)
		C2H2 Zn finger	492..512	CDD:275368	5/66 (8%)
		C2H2 Zn finger	520..540	CDD:275368	5/32 (16%)
		C2H2 Zn finger	548..568	CDD:275368	4/54 (7%)
		C2H2 Zn finger	576..596	CDD:275368	6/19 (32%)
		C2H2 Zn finger	604..624	CDD:275368	2/19 (11%)
		C2H2 Zn finger	632..652	CDD:275368	4/19 (21%)
		C2H2 Zn finger	660..680	CDD:275368	4/20 (20%)
		C2H2 Zn finger	688..708	CDD:275368	10/20 (50%)
		C2H2 Zn finger	716..736	CDD:275368	7/19 (37%)
		C2H2 Zn finger	744..764	CDD:275368	5/19 (26%)
		C2H2 Zn finger	772..792	CDD:275368	7/20 (35%)
		C2H2 Zn finger	800..820	CDD:275368	7/19 (37%)
		C2H2 Zn finger	828..848	CDD:275368	8/19 (42%)
		C2H2 Zn finger	856..876	CDD:275368	2/7 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45252
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010