DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zf30C and BC024063

DIOPT Version :9

Sequence 1:	NP_477301.1	Gene:	zf30C / 34292	FlyBaseID:	FBgn0270924	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_001360962.1	Gene:	BC024063 / 666584	MGIID:	2670978	Length:	749	Species:	Mus musculus

Alignment Length:	734	Identity:	174/734 - (23%)
Similarity:	278/734 - (37%)	Gaps:	142/734 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 CNKALVSLAGYVKHVKKHQPPGGFECRHCDARFCHEEELTQHAKDEHGVTGAVAGQERKPFVCEK 100
            |:|.:.:.....:|.:.|.....:||.:|...|.....|..|.:...|         .||:.|.:
Mouse   111 CSKPIANSNSLRQHERSHSRRKLYECNYCGKAFPSRSSLQVHERTHTG---------EKPYGCNE 166

  Fly   101 CGAEYKYQEAYRRHCRTKCGEEKLPREESRPMECKCCYTRFSSASNLSKHRRS----RP---DTC 158
            ||..:..:...:.|.||..||        :|..|..|...|:|..||..|:|:    :|   ..|
Mouse   167 CGKAFSTRSHLQIHQRTHTGE--------KPYGCSECGKAFASKGNLQTHQRTHTGEKPYCCHEC 223

  Fly   159 GQPEYDSPGSSDGMKKHKAFRKKDRNRDSDDEDTTSEESEDSDDDIPLASRLKTKLKQESQNSDS 223
            |                |||...:..:..:...|..:..|.::.....|.....:..:::...:.
Mouse   224 G----------------KAFATHNNLQIHEIIHTGEKPYECNECGRAFAYSRALEAHEKTHTGEK 272

  Fly   224 GDECPDFEPNNSEDDADASGFQLPPPAMVKVEAFDEEDFEYQDASMYVKTESTDIFSNEKDKLLD 288
            ..||      |....|.||...|    ...::....|.|       :|.|:....|:::.
Mouse   273 PYEC------NQCSKAFASHASL----RNHLKHHTGEKF-------FVCTQCGKAFTSQS----- 315

  Fly   289 VLLNEGD----GLKPFESLKVEQGAGILDEIAAVPLVEVAEEDVLEL--RGHQMEKPPGPRKRGR 347
             :|:..:    |.||:|..:..:.              .|.:..|::  |.|..|||......|:
Mouse   316 -ILHRHERTHTGEKPYECSQCGKA--------------FALQSYLQIHKRTHTGEKPYECNHCGK 365

  Fly   348 PPKEKIPVVKRKYRKRNAPRSPSPDDSSGTPKRVAKISKKELKERLKMINKMEKSWKCPHCVKIY 412
            .......:  :.:.|.:....|...:..|  |.....|..::.||....|   |.::|..|.|.:
Mouse   366 AFTSHANL--QNHEKHHTGEKPYGCNQCG--KAFVCSSSLQIHERSHTGN---KPYECNQCGKAF 423

  Fly   413 HIRKPYEKHLRDDHKLNEAEMKEIFKDVDVHAKLDEEVFKCPICSKIYLVEKRLVTHMKVHGEDG 477
            ..|...:.|.|                  :|.  .|:.:.|..|.|.:.....|..|.:.|  .|
Mouse   424 TSRSYIQIHER------------------IHT--GEKPYGCKQCGKAFAYSSSLQIHERSH--TG 466

  Fly   478 KLTFKCPCYCNLFFATKEQATEHARAQHKELLY-CEKCDKYMTGHDSLKNHERNFHSKKEPRSQQ 541
            :..|:| .:|:..||::.....|.|....|..| |..|.:......||:|||:: |:.::|..
Mouse   467 EKLFEC-THCSKAFASRSYLRIHKRVHTGEKPYECNHCGEAFASRGSLQNHEKH-HTGEKPYG-- 527

  Fly   542 RNLICDKCGKKFTGRTSLSDHVRSDCGRLPLYGCSVCGKHLSTAGILKTHMLLHKADTPYQCDKC 606
                |::|||.|..|::|..|.|...|..| |||..|||.......|:.|..:|..:.||.|.:|
Mouse   528 ----CNQCGKVFARRSNLQIHERIHTGEKP-YGCKQCGKAFVLKRDLQIHERIHTGEKPYGCKQC 587

  Fly   607 GKTFKVKAQYKSHLKTRHTDYKPYKCHLCPKEYPYRESLLTHMTVHTGIKRFLCNNCGKRFTCIS 671
            ||.|...:..|.|.:: ||..||.:|:.|.|.:..|..|..|..||||.|.:.||.|||.|...|
Mouse   588 GKAFVCSSSLKIHERS-HTGEKPCECNQCGKAFASRSYLQIHKRVHTGEKPYECNLCGKAFVSHS 651

  Fly   672 NLQAHRKVHA----DTCGQLPLNAKATQYMGVQRGKLLMGAKP----EAGMEYEETKTLIAQDVI 728
            .||.|::.|.    :.|.|......:..|:.:.: :|..|.||    :.|..:...:.|...::|
Mouse   652 YLQVHKRTHTGQKPNECNQCGKAFVSHSYLQIHK-RLHTGEKPYGCNQCGKAFTYNRDLHRHEII 715

  Fly   729 ----------DRDMPMAQE 737
                      .||...|.:
Mouse   716 HTGEKPYECNQRDKAFASQ 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zf30C	NP_477301.1	C2H2 Zn finger	33..53	CDD:275368	3/16 (19%)
		C2H2 Zn finger	61..82	CDD:275368	5/20 (25%)
		C2H2 Zn finger	98..117	CDD:275368	4/18 (22%)
		C2H2 Zn finger	134..152	CDD:275368	7/17 (41%)
		C2H2 Zn finger	511..532	CDD:275370	7/20 (35%)
		COG5048	<523..>672	CDD:227381	57/148 (39%)
		C2H2 Zn finger	546..566	CDD:275368	9/19 (47%)
		C2H2 Zn finger	575..595	CDD:275368	6/19 (32%)
		C2H2 Zn finger	603..624	CDD:275368	7/20 (35%)
		C2H2 Zn finger	632..652	CDD:275368	6/19 (32%)
		C2H2 Zn finger	660..680	CDD:275368	10/19 (53%)
BC024063	NP_001360962.1	KRAB	4..44	CDD:366587
		C2H2 Zn finger	109..128	CDD:275368	3/16 (19%)
		COG5048	132..489	CDD:227381	89/456 (20%)
		C2H2 Zn finger	136..156	CDD:275368	5/19 (26%)
		C2H2 Zn finger	164..184	CDD:275368	5/19 (26%)
		C2H2 Zn finger	192..212	CDD:275368	8/19 (42%)
		C2H2 Zn finger	220..240	CDD:275368	5/35 (14%)
		C2H2 Zn finger	248..268	CDD:275368	1/19 (5%)
		C2H2 Zn finger	276..296	CDD:275368	6/29 (21%)
		C2H2 Zn finger	304..324	CDD:275368	3/25 (12%)
		COG5048	312..736	CDD:227381	123/483 (25%)
		C2H2 Zn finger	332..352	CDD:275368	3/33 (9%)
		C2H2 Zn finger	360..380	CDD:275368	2/21 (10%)
		C2H2 Zn finger	388..408	CDD:275368	5/21 (24%)
		C2H2 Zn finger	416..436	CDD:275368	6/37 (16%)
		C2H2 Zn finger	444..464	CDD:275368	5/19 (26%)
		C2H2 Zn finger	472..492	CDD:275368	6/20 (30%)
		C2H2 Zn finger	500..520	CDD:275368	7/20 (35%)
		C2H2 Zn finger	528..548	CDD:275368	9/19 (47%)
		C2H2 Zn finger	556..576	CDD:275368	6/19 (32%)
		C2H2 Zn finger	584..604	CDD:275368	7/20 (35%)
		C2H2 Zn finger	612..632	CDD:275368	6/19 (32%)
		C2H2 Zn finger	640..660	CDD:275368	10/19 (53%)
		C2H2 Zn finger	668..688	CDD:275368	3/20 (15%)
		C2H2 Zn finger	696..716	CDD:275368	2/19 (11%)
		C2H2 Zn finger	724..744	CDD:275368	3/11 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000