DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zf30C and ZNF107

DIOPT Version :9

Sequence 1:	NP_477301.1	Gene:	zf30C / 34292	FlyBaseID:	FBgn0270924	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_001374954.1	Gene:	ZNF107 / 51427	HGNCID:	12887	Length:	896	Species:	Homo sapiens

Alignment Length:	855	Identity:	175/855 - (20%)
Similarity:	281/855 - (32%)	Gaps:	320/855 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 CNKALVSLAGYVK----------HVKKHQPPGGFECRHCDARFCHEEELTQHAKDEHGVTGAVAG 90
            |||       |||          :.::|.....|:|:.|...||...:||||.:....|..
Human   191 CNK-------YVKVFDKFSNSNRYKRRHTGNKHFKCKECSKSFCVLSQLTQHRRIHTRVNS---- 244

  Fly    91 QERKPFVCEKCGAEYKYQEAYRRHCRTKCGEEKLPREESRPMECKCCYTRFSSASNLSKHR---- 151
                 :.||:||..:.:.....:|.|...||        :|.:|:.|...|:.:|.|::|:
Human   245 -----YKCEECGKAFNWFSTLTKHKRIHTGE--------KPYKCEECGKAFNQSSQLTRHKIIHT 296

  Fly   152 RSRPDTCGQPEYDSPGSSDGMKKHKAFRKKDRNRDSDDEDTTSEESEDSDDDIPLASRLKTKLKQ 216
            ..:|:.|     :..|        |||::                          ||.|
Human   297 EEKPNKC-----EECG--------KAFKQ--------------------------ASHL------ 316

  Fly   217 ESQNSDSGDECPDFEPNNSEDDADASGFQLPPPAMVKVEAFDEEDFEYQDASMYVKTESTDIFSN 281
                                             .:.|:....|:.::|:        |...:||.
Human   317 ---------------------------------TIHKIIHTGEKPYKYE--------ECGKVFSQ 340

  Fly   282 EKDKLLDVLLNEGDGLKPFESLKVEQGAGILDEIAAVPLVEVAEEDVLELRGHQMEKPPGPRKRG 346
            ........:|:.|:.|  ::..:..:...:...:..            ..|.|..|||...::.|
Human   341 SSHLTTQKILHTGENL--YKCKECGKAFNLFSNLTN------------HKRIHAGEKPYKCKECG 391

  Fly   347 RP--------PKEKIPVVKRKYRKRNAPRSPSPDDSSGTPKRVAKIS--KKELKE---------- 391
            |.        .:|||         ....:....::......|..|::  ||.|.|
Human   392 RAFNISSNLNKQEKI---------HTGGKLNKCEECDKAFNRSLKLTAHKKILMEEKPYKCEECG 447

  Fly   392 ----------RLKMINKMEKSWKCPHCVKIYHIRKPYEKHLRDDHKLNEAE----MKEIFKDVDV 442
                      |.|:|:..||.:||..|.|.::    ...:|.:..|::.||    .:|..|..:.
Human   448 KVFNQFSTLTRHKIIHTGEKPYKCKECGKAFN----QSSNLTEHKKIHTAEKSYKCEECGKAFNQ 508

  Fly   443 HAKL--------DEEVFKCPICSKIYLVEKRLVTHMKVHGEDGKLTFKCPCYCNLFFATKEQATE 499
            |:.|        .|:.:||..|.|.:.....|..|.|:|  .|:..:||. .|:..|:.....||
Human   509 HSNLINHRKIYSGEKPYKCEECGKAFNRSSTLTRHKKIH--TGEKPYKCE-ECDRAFSQSSNLTE 570

  Fly   500 HARAQHKELLY-CEKCDKYMTGHDSLKNHERNFHSKKEPR------------------------- 538
            |.:....|..| ||:|.|......:|..|:| .|:.::|.
Human   571 HKKIHTGEKPYKCEECGKAFNRFSTLTKHKR-IHTGEKPYKCEECGKAFNQSYQLTRHKIVHTKE 634

  Fly   539 ----------------------------------------SQQRNLI------------------ 545
                                                    :|..||.
Human   635 KLNKCEEFGKAFKQSSHRTIHKIIHTGEKPYKCEEHGKVFNQSSNLTTQKIIHTGENLYKFEEHG 699

  Fly   546 -----------------------CDKCGKKFTGRTSLSDHVRSDCGRLPLYGCSVCGKHLSTAGI 587
                                   |::|||.:...::|:.|.|...|..| |.|:.|||..:.:..
Human   700 KAFNLFSNITNHKIIYTGEKPHKCEECGKAYNRFSNLTIHKRIHTGEKP-YQCAECGKAFNCSST 763

  Fly   588 LKTHMLLHKADTPYQCDKCGKTFKVKAQYKSHLKTRHTDYKPYKCHLCPKEYPYRESLLTHMTVH 652
            |..|.::|..:.||:|.:|||.|.:.:...:|.|. ||..|||||..|.|.:....:|.||..:|
Human   764 LNRHKIIHTGEKPYKCKECGKAFNLSSTLTAHKKI-HTGEKPYKCEECGKAFNQSSNLTTHKKIH 827

  Fly   653 TGIKRFLCNNCGKRFTCISNLQAHRKVHAD----TCGQ----LPLNAKATQYMGVQRGKLLMGAK 709
            |..|.:.|..|||.|...|:|..|:.:|..    .||.    ..|::..|.:.     |:..|.|
Human   828 TSEKPYKCEECGKSFNQFSSLNIHKIIHTGEKPYKCGDYGRAFNLSSNLTTHK-----KIHTGEK 887

  Fly   710 PEAGMEYEET 719
            |.. .||.:|
Human   888 PYK-CEYGKT 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zf30C	NP_477301.1	C2H2 Zn finger	33..53	CDD:275368	6/26 (23%)
		C2H2 Zn finger	61..82	CDD:275368	8/20 (40%)
		C2H2 Zn finger	98..117	CDD:275368	5/18 (28%)
		C2H2 Zn finger	134..152	CDD:275368	6/21 (29%)
		C2H2 Zn finger	511..532	CDD:275370	7/20 (35%)
		COG5048	<523..>672	CDD:227381	54/254 (21%)
		C2H2 Zn finger	546..566	CDD:275368	7/19 (37%)
		C2H2 Zn finger	575..595	CDD:275368	6/19 (32%)
		C2H2 Zn finger	603..624	CDD:275368	7/20 (35%)
		C2H2 Zn finger	632..652	CDD:275368	6/19 (32%)
		C2H2 Zn finger	660..680	CDD:275368	8/19 (42%)
ZNF107	NP_001374954.1	KRAB	48..108	CDD:214630
		C2H2 Zn finger	191..211	CDD:275368	6/26 (23%)
		C2H2 Zn finger	219..239	CDD:275368	8/19 (42%)
		COG5048	243..621	CDD:227381	94/511 (18%)
		C2H2 Zn finger	247..267	CDD:275368	6/19 (32%)
		C2H2 Zn finger	275..295	CDD:275368	6/19 (32%)
		C2H2 Zn finger	303..323	CDD:275368	9/97 (9%)
		C2H2 Zn finger	331..351	CDD:275368	4/27 (15%)
		C2H2 Zn finger	359..379	CDD:275368	1/31 (3%)
		C2H2 Zn finger	387..407	CDD:275368	5/28 (18%)
		C2H2 Zn finger	415..435	CDD:275368	4/19 (21%)
		C2H2 Zn finger	443..463	CDD:275368	2/19 (11%)
		C2H2 Zn finger	471..491	CDD:275368	5/23 (22%)
		C2H2 Zn finger	499..519	CDD:275368	4/19 (21%)
		C2H2 Zn finger	527..547	CDD:275368	6/19 (32%)
		COG5048	551..>863	CDD:227381	71/315 (23%)
		C2H2 Zn finger	555..575	CDD:275368	6/20 (30%)
		C2H2 Zn finger	583..603	CDD:275368	7/20 (35%)
		C2H2 Zn finger	611..631	CDD:275368	0/19 (0%)
		C2H2 Zn finger	639..659	CDD:275368	0/19 (0%)
		C2H2 Zn finger	699..715	CDD:275368	0/15 (0%)
		C2H2 Zn finger	723..743	CDD:275368	7/19 (37%)
		C2H2 Zn finger	751..771	CDD:275368	6/19 (32%)
		C2H2 Zn finger	779..799	CDD:275368	7/20 (35%)
		C2H2 Zn finger	807..827	CDD:275368	6/19 (32%)
		C2H2 Zn finger	835..855	CDD:275368	8/19 (42%)
		C2H2 Zn finger	863..883	CDD:275368	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142203
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930