DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zf30C and Zfp62

DIOPT Version :9

Sequence 1:	NP_477301.1	Gene:	zf30C / 34292	FlyBaseID:	FBgn0270924	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	XP_006246250.1	Gene:	Zfp62 / 497894	RGDID:	1560191	Length:	924	Species:	Rattus norvegicus

Alignment Length:	749	Identity:	189/749 - (25%)
Similarity:	273/749 - (36%)	Gaps:	179/749 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 CPVCNKALVSLAGYVKHVKKHQPPGGFECRHCDARFCHEEELTQHAKDEHGVTGAVAGQERKPFV 97
            |..|.||.:|.:..:.|...|......:|..|...|.:...|.||.:...|         .||:.
  Rat   199 CDECGKAYMSYSSLINHKSTHSGEKNCKCDECGKSFNYSSVLDQHKRIHTG---------EKPYE 254

  Fly    98 CEKCGAEYKYQEAYRRHCRTKCGEEKLPREESRPMECKCCYTRFSSASNLSKHRR----SRP--- 155
            |.:||..::.....|.|.|...||        :|.||..|...||::|.|..|:|    .:|
  Rat   255 CGECGKAFRNSSGLRVHKRIHTGE--------KPYECDICGKTFSNSSGLRVHKRIHTGEKPYEC 311

  Fly   156 DTCGQPEYDSPGSSDGMKKHKAFRKKDRNRDSDDEDTTSEESEDSDDDIPLASRLKTKLKQESQN 220
            |.||:...    :...:..||:....|:....|       |.|.|.:...|.  ::.|:....:.
  Rat   312 DECGKAFI----TCRTLLNHKSIHFGDKPYKCD-------ECEKSFNYSSLL--IQHKVIHTGEK 363

  Fly   221 SDSGDECPDFEPNNS---------------------EDDADASGFQLPPPAMVKVEAFDEED--- 261
            ....|||.....|:|                     :..:.:||..:........:|.:.:|
  Rat   364 PYECDECGKAFRNSSGLIVHKRIHTGEKPYKCDICGKAFSYSSGLAVHKSIHPGKKAHECKDCGK 428

  Fly   262 -FEYQDASMYVKTESTDIFSNEKDKLLDVLLNEGDGLKPFESLKVEQGAGILDEIAAVPLVEVAE 325
             |.|....:..||    |.:.|:..:.||.   |...:....|||.:
  Rat   429 SFSYNSLLLQHKT----IHTGERPYVCDVC---GKTFRNNSGLKVHR------------------ 468

  Fly   326 EDVLELRGHQMEKPPGPRKRGRPPKEKIPVVKRKYRKRNAPRSPSPDDSSGTPKRVAKISKKELK 390
                  |.|..|||           .|..|..:.|                       ||:..||
  Rat   469 ------RLHTGEKP-----------YKCDVCGKAY-----------------------ISRSSLK 493

  Fly   391 ERLKMINKMEKSWKCPHCVKIYHIRKPYEKHLR---DDHKLNEAEMKEIFKD---VDVHAKL--D 447
            .. |.|:..||.:||.:|.|.::.....|:|.|   .:......|..:.|::   :.||.::  .
  Rat   494 NH-KGIHLGEKPYKCSYCEKSFNYSSALEQHKRIHTREKPFGCDECGKAFRNNSGLKVHKRIHTG 557

  Fly   448 EEVFKCPICSKIYLVEKRLVTHMKVHGEDGKLTFKCPCYCNLFFATKEQATEHARAQHKELLY-C 511
            |..:||..|.|.|:....|:.|..||  .|:..|||. .|...|.|......|.:....|..| |
  Rat   558 ERPYKCEECGKAYISLSSLINHKSVH--PGEKPFKCD-ECEKAFITYRTLLNHKKIHLGEKPYKC 619

  Fly   512 EKCDKYMTGHDSLKNHERNFHSKKEPRSQQRNLICDKCGKKFTGRTSLSDHVRSDCGRLPLYGCS 576
            :.|:|.......|..|:| .|::::|      ..||:|.|.|...:||..|.|...|..| |.|.
  Rat   620 DVCEKSFNYTSLLSQHKR-VHTREKP------FECDRCEKVFRNNSSLKVHKRIHTGEKP-YECD 676

  Fly   577 VCGKHLSTAGILKTHMLLHKADTPYQCDKCGKTFKVKAQYKSHLKTRHTDYKPYKCHLCPKEYPY 641
            :|||...:...|..|...|...|||.||:|||.|.......|| |..|...||:||..|.|.:.|
  Rat   677 ICGKAYISHSSLINHKSTHPGKTPYTCDECGKAFFSSRTLISH-KRVHLGEKPFKCVECGKSFSY 740

  Fly   642 RESLLTHMTVHTGIKRFLCNNCGKRFTCISNLQAHRKVH-------ADTC--------------- 684
            ...|..|..:|||.|.::|:.|||.|...|.|..|:::|       .|.|
  Rat   741 SSLLSQHKRIHTGEKPYICDWCGKAFRNSSGLTVHKRIHTGEKPYGCDECEKAYISHSSLINHKS 805

  Fly   685 ---GQLPLN---AKATQYMGV--QRGKLLMGAKP 710
               |:.|.|   .|:..|..|  |..::..|.||
  Rat   806 VHRGKQPYNCECGKSFNYRSVLDQHKRIHTGKKP 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zf30C	NP_477301.1	C2H2 Zn finger	33..53	CDD:275368	6/19 (32%)
		C2H2 Zn finger	61..82	CDD:275368	6/20 (30%)
		C2H2 Zn finger	98..117	CDD:275368	5/18 (28%)
		C2H2 Zn finger	134..152	CDD:275368	7/17 (41%)
		C2H2 Zn finger	511..532	CDD:275370	6/20 (30%)
		COG5048	<523..>672	CDD:227381	55/148 (37%)
		C2H2 Zn finger	546..566	CDD:275368	9/19 (47%)
		C2H2 Zn finger	575..595	CDD:275368	6/19 (32%)
		C2H2 Zn finger	603..624	CDD:275368	9/20 (45%)
		C2H2 Zn finger	632..652	CDD:275368	6/19 (32%)
		C2H2 Zn finger	660..680	CDD:275368	8/19 (42%)
Zfp62	XP_006246250.1	COG5048	125..552	CDD:227381	94/448 (21%)
		C2H2 Zn finger	143..163	CDD:275368
		C2H2 Zn finger	171..191	CDD:275368
		C2H2 Zn finger	199..219	CDD:275368	6/19 (32%)
		C2H2 Zn finger	227..247	CDD:275368	6/19 (32%)
		C2H2 Zn finger	255..275	CDD:275368	6/19 (32%)
		C2H2 Zn finger	283..303	CDD:275368	8/19 (42%)
		C2H2 Zn finger	311..331	CDD:275368	5/23 (22%)
		C2H2 Zn finger	339..359	CDD:275368	6/28 (21%)
		C2H2 Zn finger	367..387	CDD:275368	5/19 (26%)
		SFP1	<389..468	CDD:227516	16/85 (19%)
		C2H2 Zn finger	395..415	CDD:275368	2/19 (11%)
		C2H2 Zn finger	423..443	CDD:275368	5/23 (22%)
		COG5048	447..860	CDD:227381	127/467 (27%)
		C2H2 Zn finger	451..471	CDD:275368	7/46 (15%)
		C2H2 Zn finger	479..499	CDD:275368	7/43 (16%)
		C2H2 Zn finger	507..527	CDD:275368	6/19 (32%)
		C2H2 Zn finger	535..555	CDD:275368	4/19 (21%)
		C2H2 Zn finger	563..583	CDD:275368	6/19 (32%)
		C2H2 Zn finger	591..611	CDD:275368	5/20 (25%)
		C2H2 Zn finger	619..639	CDD:275368	6/20 (30%)
		C2H2 Zn finger	647..667	CDD:275368	9/19 (47%)
		C2H2 Zn finger	675..695	CDD:275368	6/19 (32%)
		C2H2 Zn finger	703..723	CDD:275368	9/20 (45%)
		C2H2 Zn finger	731..751	CDD:275368	6/19 (32%)
		C2H2 Zn finger	759..779	CDD:275368	8/19 (42%)
		C2H2 Zn finger	787..807	CDD:275368	2/19 (11%)
		C2H2 Zn finger	815..834	CDD:275368	4/18 (22%)
		C2H2 Zn finger	842..862	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000