DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zf30C and CG17803

DIOPT Version :9

Sequence 1:	NP_477301.1	Gene:	zf30C / 34292	FlyBaseID:	FBgn0270924	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_001303488.1	Gene:	CG17803 / 42141	FlyBaseID:	FBgn0038547	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	631	Identity:	127/631 - (20%)
Similarity:	202/631 - (32%)	Gaps:	222/631 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 PPGGFECRHC--------DARFCHEE---ELTQHAKDEHGVTGAVAGQERKPFVCEKCGAEYKYQ 108
            ||...:||.|        ||:..::.   .|..|.|...||......:|....:|..|      |
  Fly    80 PPPASKCRTCFRIISRHEDAQDLYDRVNIALLHHIKVITGVWIQQGVKELPHHICSTC------Q 138

  Fly   109 EAYRR--HCRTKCGE-EKLPREESRPMECKCCYTRFSSASNLSKHRRSRPDTCGQPEYDSPGSSD 170
            |...:  ..|.||.: :|..|:.:.....:.|
  Fly   139 ETVNKSMEFRAKCQQVDKKLRQTTEKYNIQIC--------------------------------- 170

  Fly   171 GMKKHKAFRKKDRNRDSDDEDTTSEESEDSDDDIPLASRLKTKLKQESQNSDSGDECP-DFEPNN 234
                       |...:|:.|:...|||......:.......::|..:|:.....|:.| |.||..
  Fly   171 -----------DEEMESELENVLYEESAQQAKGVVGLEDFSSELLPDSEGVLDEDDFPLDAEPTQ 224

  Fly   235 ---SEDDADASGFQLPPPAMVKVEAFDEEDFEYQDASMYVKTESTDIFSNEKDKLLDVLLNEGDG 296
               |||:.|             ::...|:|                 |:.|::|..:.:::
  Fly   225 FSLSEDELD-------------LDRDTEKD-----------------FALEQNKSCNEIIS---- 255

  Fly   297 LKPFESLKVEQGAGILDEIAAVPLVEVAEEDVLELRGHQMEKPPGPRKRGRPPKEKIPVVKRKYR 361
               ....|.::..|.:|..|.|..|.:.|.:.|                    ||..|    ||
  Fly   256 ---IRKCKTKEEIGKVDHGAKVYKVVLGEYNSL--------------------KETAP----KY- 292

  Fly   362 KRNAPRSP----SPDDSSGTPKRVAKISKKELKERLKMINKMEKSWKCPHCVKIYHIRKPYEKH- 421
            ..:.|:.|    ||::.:  .:|..:|..|.|            ::.|..|...:..|...:.|
  Fly   293 SLSLPKKPQLRVSPEEKN--RRRRERIQAKPL------------NYVCDKCGHTFRQRSQLQMHL 343

  Fly   422 LRDDHKLNEAEMKEIFKDVDVHAKLDEEVFKCPIC-SKIYLVEKRLVTHMKVHGEDGKLTFKCPC 485
            ||.:...|                     |:||.| .|.|.:..|.:
  Fly   344 LRHNRAKN---------------------FECPECPKKFYDLYTRNI------------------ 369

  Fly   486 YCNLFFATKEQATEHARAQHK--ELLYCEKCDKYMTGHDSLKNHERNFH-----------SKKEP 537
                          |.||.||  ....|..|::......|...|||:.|           ||:|.
  Fly   370 --------------HVRALHKGEHPFPCNHCNESFANASSRHRHERDVHGAGNRIRTRVKSKEEG 420

  Fly   538 RSQQRNLICDKCGKKFTGRTSLSDHVRSDCGRLPLYGCSVCGKHLSTAGILKTHMLLHKADTPYQ 602
            .|:.   .|.:|.|.:|.:..|..|:....|..| :.|.:|....:....:|.|..||. ..|.:
  Fly   421 SSRH---YCTQCTKSYTSKKGLVLHMNFHNGSRP-FQCKICQMKFADPSAMKRHQALHD-KFPIR 480

  Fly   603 CDKCGKTFKVKAQYKSHLKTRHTDYKPYKCHLCPKEYPYRESLLTH 648
            ||.|.|.|.:::|...| :..||...|::|.:|...|.:|.:|..|
  Fly   481 CDICLKGFLLRSQLTKH-QDVHTGMHPHRCEICDVHYRHRYNLNKH 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zf30C	NP_477301.1	C2H2 Zn finger	33..53	CDD:275368
		C2H2 Zn finger	61..82	CDD:275368	8/31 (26%)
		C2H2 Zn finger	98..117	CDD:275368	4/20 (20%)
		C2H2 Zn finger	134..152	CDD:275368	1/17 (6%)
		C2H2 Zn finger	511..532	CDD:275370	6/20 (30%)
		COG5048	<523..>672	CDD:227381	40/137 (29%)
		C2H2 Zn finger	546..566	CDD:275368	6/19 (32%)
		C2H2 Zn finger	575..595	CDD:275368	4/19 (21%)
		C2H2 Zn finger	603..624	CDD:275368	7/20 (35%)
		C2H2 Zn finger	632..652	CDD:275368	6/17 (35%)
		C2H2 Zn finger	660..680	CDD:275368
CG17803	NP_001303488.1	zf-AD	86..160	CDD:214871	19/79 (24%)
		COG5048	<323..528	CDD:227381	61/262 (23%)
		zf-C2H2	324..346	CDD:278523	5/21 (24%)
		C2H2 Zn finger	326..346	CDD:275368	5/19 (26%)
		C2H2 Zn finger	354..375	CDD:275368	9/52 (17%)
		C2H2 Zn finger	383..401	CDD:275368	4/17 (24%)
		C2H2 Zn finger	426..446	CDD:275368	6/19 (32%)
		C2H2 Zn finger	454..474	CDD:275368	4/19 (21%)
		C2H2 Zn finger	481..501	CDD:275368	7/20 (35%)
		C2H2 Zn finger	509..528	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455482
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930