DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zf30C and CG2678

DIOPT Version :9

Sequence 1:	NP_477301.1	Gene:	zf30C / 34292	FlyBaseID:	FBgn0270924	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_649750.1	Gene:	CG2678 / 40937	FlyBaseID:	FBgn0014931	Length:	434	Species:	Drosophila melanogaster

Alignment Length:	645	Identity:	126/645 - (19%)
Similarity:	183/645 - (28%)	Gaps:	247/645 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 CRHCDARFCHEEELTQHAKDEHGVTGAVAGQERKPFVCEKCGAEYKYQEAYRRHCRTKCGEEKLP 125
            ||.|              .||.|....:....|.|.:.|        .|....|...:|.|..:.
  Fly     9 CRTC--------------MDETGTLVDIFANVRDPVLDE--------PEMSLSHILARCTERPVK 51

  Fly   126 REESRP-MECKCCYT------RFSSASNLS-KHRRSRPDTCGQPEYDSPGSSDGMKKHKAFRKKD 182
            |.:..| ..|..|..      ||...|..| :|.....:..|.||         .:.|.|....|
  Fly    52 RGDLLPQFICVSCVLAVQNAFRFKWQSEQSYQHFFRVLNQSGAPE---------NQVHLAACNGD 107

  Fly   183 RNRDSDDEDTTSEESEDSDDDIPLASRLKTKLKQESQNSDSGDECPDFEPNNSEDDADASGFQLP 247
            :|:..:.                     |.:||.:.|
  Fly   108 KNQIINQ---------------------KMQLKSDRQ---------------------------- 123

  Fly   248 PPAMVKVEAFDEEDFEYQDASMYVKTESTDIFSNEKDKLLDVLLNEGDGLKPFESLKVEQGAGIL 312
                             ||.....||:..|...::| :.|...|.||:...|.||..:.
  Fly   124 -----------------QDTQQMTKTQKPDDDLSQK-QTLQAKLQEGNIDGPPESFTLH------ 164

  Fly   313 DEIAAVPLVEVAEEDVLELRGHQMEKPPGPRKRGRPPKEKIPVVKRKYRKRNAPRSPSPDDSSGT 377
                                         ||||....:|:
  Fly   165 -----------------------------PRKRTCRTEEQ------------------------- 175

  Fly   378 PKRVAKISKKELKERLKMINKMEKSWKCPHCVKIYHIRKPYEKHLRDDHKLNEAEMKEIFKDVDV 442
                |.:..||.....|||...:..:.||||.|.:..:.....|:.|  ..|
  Fly   176 ----ADMIPKEATRSTKMICDADGYYNCPHCSKRFCSQTQLRTHITD--LCN------------- 221

  Fly   443 HAKLDEEVFKCPICSKIYLVEKRLVTHMKVHGEDGKLTFKCPCYCNLFFATKEQATEHARAQHKE 507
                     :||.|.:.|:.:..|..|::.|  ..|...|| .:|:..|..|:....|.|....:
  Fly   222 ---------RCPYCPRTYMQKSNLKRHLRNH--LSKPAHKC-FHCSKAFMRKDHLKRHLRTHDSD 274

  Fly   508 -LLYCEKCDKYMTGHDSLKNHERNF---------HSKKEPRSQQRNLICDKCGK----KFTGRTS 558
             .|.|.:|......|..|:.|.|..         .|.|:|.|...:...|...|    .|.|..|
  Fly   275 GPLSCSQCSAVFIEHVQLEIHRREHKQRPGSSKSESTKDPDSDDSDQAQDLKPKWTKNTFNGTCS 339

  Fly   559 LSDHVRSDCGRLPLYGCSVCGKHLSTAGILKTHMLLHKADTPYQCDKCGKTFKVKAQYKSHLKTR 623
            :...::      |...|.:|.|..|:...||.|||.|..                   :.|||
  Fly   340 IPPMLK------PKPICDICQKKFSSVYALKRHMLTHNR-------------------QHHLK-- 377

  Fly   624 HTDYKPYKCHLCPKEYPYRESLLTHMTVHTGIKRFLCNNCGKRFTCISNLQAHRK-VHAD 682
                   ||..|.:|:...:.|..|...|.| ..|.|..|...|..::.|:.|:| :|::
  Fly   378 -------KCTYCSEEFKTEKHLKRHERGHMG-DLFRCEFCSLVFVDVNYLRKHKKRIHSN 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zf30C	NP_477301.1	C2H2 Zn finger	33..53	CDD:275368
		C2H2 Zn finger	61..82	CDD:275368	4/20 (20%)
		C2H2 Zn finger	98..117	CDD:275368	3/18 (17%)
		C2H2 Zn finger	134..152	CDD:275368	7/24 (29%)
		C2H2 Zn finger	511..532	CDD:275370	6/29 (21%)
		COG5048	<523..>672	CDD:227381	38/161 (24%)
		C2H2 Zn finger	546..566	CDD:275368	5/23 (22%)
		C2H2 Zn finger	575..595	CDD:275368	9/19 (47%)
		C2H2 Zn finger	603..624	CDD:275368	3/20 (15%)
		C2H2 Zn finger	632..652	CDD:275368	5/19 (26%)
		C2H2 Zn finger	660..680	CDD:275368	6/20 (30%)
CG2678	NP_649750.1	zf-AD	8..85	CDD:214871	21/97 (22%)
		COG5048	220..>284	CDD:227381	19/88 (22%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		zf-C2H2	249..271	CDD:278523	7/22 (32%)
		C2H2 Zn finger	251..271	CDD:275368	6/20 (30%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		C2H2 Zn finger	350..370	CDD:275368	9/19 (47%)
		C2H2 Zn finger	379..399	CDD:275368	5/19 (26%)
		C2H2 Zn finger	406..427	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100