DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zf30C and CG8089

DIOPT Version :9

Sequence 1:	NP_477301.1	Gene:	zf30C / 34292	FlyBaseID:	FBgn0270924	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_611014.1	Gene:	CG8089 / 36679	FlyBaseID:	FBgn0033993	Length:	624	Species:	Drosophila melanogaster

Alignment Length:	637	Identity:	121/637 - (18%)
Similarity:	203/637 - (31%)	Gaps:	248/637 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 ERKPFVC-EKCGAEYKYQEAYRRHCRTKCGEEKLPREESRPMECKCC------YTRFSSASNLSK 149
            ::||:.| ..|            ||:                 ||||      |..|:..
  Fly    24 DKKPYGCPASC------------HCK-----------------CKCCRGFREKYVAFNGE----- 54

  Fly   150 HRRSRPDTCGQPEYDSPGSS---DGMKKHKAFRKKD-----RNRDSDDEDTTSEE-SEDSDDDI- 204
                     |:..:.:..||   :.::|...||..|     |.....|...|:|. ..|..||.
  Fly    55 ---------GETIFGTDFSSELCEDVQKIMRFRSSDMLLLLRTAQLRDNFWTNEYFKADLQDDFR 110

  Fly   205 ----------------PLASRLKTKLK--QESQNSDSGDE------------------CPDFEPN 233
                            .||:.|.|...  :.|.:..:|.|                  |..::..
  Fly   111 AIFDAFEEKNRKVQLEKLAAILDTVSSGYRRSVSQLAGQEAHGALRPKIAALFLPGLRCDCYKCE 175

  Fly   234 NSEDDADASGFQLPPPAMVKVEAFDEEDFEYQD--------ASMYVK-----------TESTDIF 279
            |           ||...:..||. .::...|.|        ...|::           |.|.::.
  Fly   176 N-----------LPWKKLQDVED-HQKTHRYSDNFHCQICYRRFYLQHSLTSHIIRKSTSSRELH 228

  Fly   280 SNEKDKLLDVLLNEGDGLKPFESLKVEQGAGILDEIAAVPLVEVAEEDVLELRGHQMEKPPGPRK 344
            .|::.|.|  |.|:    |..|..::|.....:::|    ||.|||    :|:.:..:
  Fly   229 ENKRYKRL--LENQ----KSQEEKELELSLNKVEDI----LVPVAE----DLQSYFKD------- 272

  Fly   345 RGRPPKEKIPVVKRKYRKRNAPRSPSPDDSSGTPKRVAKISKKELKERLKMINKMEKSWKCPHCV 409
                 :.|.|:.|||                     .:.:|                  |||.|.
  Fly   273 -----ESKHPIQKRK---------------------TSSLS------------------KCPSCA 293

  Fly   410 KIYHIRKPYEKHLRDDHKLNEAEMKEIFKDVDVHAKLDEEVFKCPICSKIYLVEKRLVTHMKVHG 474
            :.|.....::.|:....:      :.::.:...|         |..|::.:|..|.|..|.:...
  Fly   294 QNYGFSFSHQLHMVKHRR------ERLYTNFPFH---------CSFCNRSFLTRKFLRKHQQRVR 343

  Fly   475 EDGKL---TFKCPCYCNLFFATKEQATEHARAQH---KELLYC--------------EKCDKYMT 519
            ....|   .|||| :|...|..|.....|....|   |..|.|              ::|::
  Fly   344 TFSTLLYRPFKCP-HCTWRFQLKSALDSHVLRIHERRKPCLICKLPTSRLCCSAHTSKECNR--- 404

  Fly   520 GHDSLKNHERNFHSKKEPRS----QQRNLICDKCGKKFTGRTSLSDHVRSDCGRLPLYGCSVCGK 580
               :::.:.......:||..    :|...:|..|.:|||.:..|.:|:.........:.|.:||.
  Fly   405 ---AMQKYRDKMRPLREPPKGGCRKQPTPVCKICNRKFTRKFFLEEHMNKAHLNKRNFTCEICGA 466

  Fly   581 HLSTAGILKT-----HMLLHKADTPYQCDKCGKTFKVKAQYKSHLKTR-HTD 626
            :..:.|.::|     |:|:|..    ||:.|..|.|.|..|:.|.|:: |.|
  Fly   467 NFYSQGTMQTHRKAVHLLVHTV----QCEVCDLTIKSKGNYRRHCKSQSHKD 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zf30C	NP_477301.1	C2H2 Zn finger	33..53	CDD:275368
		C2H2 Zn finger	61..82	CDD:275368
		C2H2 Zn finger	98..117	CDD:275368	4/19 (21%)
		C2H2 Zn finger	134..152	CDD:275368	6/23 (26%)
		C2H2 Zn finger	511..532	CDD:275370	2/34 (6%)
		COG5048	<523..>672	CDD:227381	29/114 (25%)
		C2H2 Zn finger	546..566	CDD:275368	7/19 (37%)
		C2H2 Zn finger	575..595	CDD:275368	7/24 (29%)
		C2H2 Zn finger	603..624	CDD:275368	8/21 (38%)
		C2H2 Zn finger	632..652	CDD:275368
		C2H2 Zn finger	660..680	CDD:275368
CG8089	NP_611014.1	C2H2 Zn finger	289..309	CDD:275368	5/19 (26%)
		C2H2 Zn finger	322..343	CDD:275368	6/20 (30%)
		C2H2 Zn finger	355..376	CDD:275368	6/21 (29%)
		C2H2 Zn finger	432..453	CDD:275368	7/20 (35%)
		C2H2 Zn finger	461..486	CDD:275368	7/24 (29%)
		C2H2 Zn finger	490..506	CDD:275368	6/15 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455455
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930