DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zf30C and CG12299

DIOPT Version :9

Sequence 1:	NP_477301.1	Gene:	zf30C / 34292	FlyBaseID:	FBgn0270924	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster

Alignment Length:	690	Identity:	152/690 - (22%)
Similarity:	238/690 - (34%)	Gaps:	203/690 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 EKLPREESRP---MECKCCYTRFSSASNLSKHRRS----RPDTCGQPEYDSPG------------ 167
            ::.|::...|   ..|.||...|.....|.:|..:    .|.. ||.|.:|||
  Fly    35 QQQPQQPQPPDLTFHCMCCAEFFVHPLALYQHMNTLHPHEPGN-GQQEQESPGDESEDYSWIFEP 98

  Fly   168 ----------SSDGMKKHKAFRKKDRNRDSDDEDTTSEESEDSDDDIPLASRLKTKLKQESQNSD 222
                      ||||    .|....|.:..|||:|      :|.|||...:|      ...|.:|.
  Fly    99 VCELAEDGSDSSDG----SASSGSDSSSSSDDDD------DDDDDDSSSSS------SSSSNSSS 147

  Fly   223 SGDECPDFEPNNSEDDADASGFQLPPPAMVKVEAFDEEDFEYQDASMYVKTESTDIFSNEKDKLL 287
            |....|....:|::...::   ..|...:|....::|...:..|     ..|||.||.
  Fly   148 SSSSVPTTSNSNTQQSQES---VQPLHGLVAGPGYNEFQLQMTD-----PRESTSIFM------- 197

  Fly   288 DVLLNEGDGLKPFESLKVEQGAGILDEIAAVPLVEVAEEDVLELRGHQMEKPPGPRKRGRPPKEK 352
                                   :...::..||              |...||.|........:.
  Fly   198 -----------------------VQPTVSVTPL--------------QQLLPPAPTVSPGLGLQS 225

  Fly   353 IPVVKRKYRKRNAPRSPSPDDSSGTPKRVAKISKKELKERLKMINKMEKSWKCPHCVKIYHIRKP 417
            .|:.:|:.|:.|. .:|..|.:                     :|..:|.::|.||...:.....
  Fly   226 TPIKRRRGRRSNI-GAPVMDPA---------------------LNGNQKCFQCTHCEASFPNAGD 268

  Fly   418 YEKHLRDDHKLNEAEMKEIFKDVDVHAKLDEEVFKCPICSKIYLVEKRLVTHMKVHGEDGKLTFK 482
            ..||:| .|..|:.                   |:|.||.|.:.....|.||:::|  .|:..:|
  Fly   269 LSKHVR-SHITNKP-------------------FQCSICQKTFTHIGSLNTHIRIH--SGEKPYK 311

  Fly   483 CPCYCNLFFATKEQATEHARAQ-----HKELLYCEKCDKYMTGHDSLKNHERNFHSKKEPRSQQR 542
            |. .|...|........|.|:.     |:    |.:|||....:.||..|::...:..|
  Fly   312 CE-LCPKAFTQSSSLMVHMRSHSVRKPHQ----CVQCDKGFINYSSLLLHQKTHIAPTE------ 365

  Fly   543 NLICDKCGKKFTGRTSLSDHVRSDCGRLPLYGCSVCGKHLSTAGILKTHMLLHKADTPYQCDKCG 607
            ..||.:|.::|.....|.:|:|.....| :|.|::|.:....:..|..||..|..:.|:.|..|.
  Fly   366 TFICPECEREFKAEALLDEHMRMHTQEL-VYQCAICREAFRASSELVQHMKNHMGEKPFTCSLCD 429

  Fly   608 KTFKVKAQYKSHLKTRHTDYKPYKCHLCPKEYPYRESLLTHMTVHTGIKRFLCNNCGKRFTCISN 672
            ::|........|::. ||..||::|.||.|.:....||..||.:|.|.|.:.|..|||.::..:.
  Fly   430 RSFTQSGSLNIHMRI-HTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKPYPCPICGKSYSQQAY 493

  Fly   673 LQAHRKVH-------ADT------------------CGQLPLNAKA-TQYMGVQRGKLL------ 705
            |..|.:.|       |.|                  ||.|..:|.| ..::..|...||
  Fly   494 LNKHIQAHQMASAASASTSPGLLVAKQPHETLVCIVCGSLHADATALASHVHSQHAALLDTMKQS 558

  Fly   706 ------MGAKPEAGMEYEETKTLIAQDVIDRDMPMAQELN 739
                  .||.|:.....||     .|..::|...:.|::|
  Fly   559 GMNTAPGGAIPDVKCSAEE-----QQAYVERVQCVLQQMN 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zf30C	NP_477301.1	C2H2 Zn finger	33..53	CDD:275368
		C2H2 Zn finger	61..82	CDD:275368
		C2H2 Zn finger	98..117	CDD:275368
		C2H2 Zn finger	134..152	CDD:275368	6/17 (35%)
		C2H2 Zn finger	511..532	CDD:275370	7/20 (35%)
		COG5048	<523..>672	CDD:227381	43/148 (29%)
		C2H2 Zn finger	546..566	CDD:275368	6/19 (32%)
		C2H2 Zn finger	575..595	CDD:275368	5/19 (26%)
		C2H2 Zn finger	603..624	CDD:275368	4/20 (20%)
		C2H2 Zn finger	632..652	CDD:275368	8/19 (42%)
		C2H2 Zn finger	660..680	CDD:275368	6/19 (32%)
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	45/192 (23%)
		C2H2 Zn finger	256..276	CDD:275368	6/20 (30%)
		zf-H2C2_2	268..293	CDD:290200	10/44 (23%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-H2C2_2	296..321	CDD:290200	9/27 (33%)
		zf-C2H2_2	312..>387	CDD:289522	20/85 (24%)
		C2H2 Zn finger	312..332	CDD:275368	5/20 (25%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		C2H2 Zn finger	369..389	CDD:275368	6/19 (32%)
		C2H2 Zn finger	397..417	CDD:275368	5/19 (26%)
		zf-H2C2_2	409..434	CDD:290200	8/24 (33%)
		C2H2 Zn finger	425..445	CDD:275368	4/20 (20%)
		zf-H2C2_2	437..462	CDD:290200	9/25 (36%)
		C2H2 Zn finger	453..473	CDD:275368	8/19 (42%)
		zf-H2C2_2	465..490	CDD:290200	11/24 (46%)
		C2H2 Zn finger	481..501	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010