DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zf30C and Zfp780b

DIOPT Version :9

Sequence 1:	NP_477301.1	Gene:	zf30C / 34292	FlyBaseID:	FBgn0270924	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_001074490.1	Gene:	Zfp780b / 338354	MGIID:	2444764	Length:	806	Species:	Mus musculus

Alignment Length:	721	Identity:	163/721 - (22%)
Similarity:	269/721 - (37%)	Gaps:	179/721 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EITT-DGIP-------------KLHCPVCNKALVSLAGYVKHVKKHQPPGGFECRHCDARFCHEE 72
            :||. :|:|             ...|..|.|.....:...:|...|.....:||..|...|...:
Mouse   148 QITNKEGVPPHTCQTLAHNTEKPYECKECGKCFGCRSTLTQHQSIHTGEKPYECEECGKAFRLPQ 212

  Fly    73 ELTQHAKDEHGVTGAVAGQERKPFVCEKCGAEYKYQEAYRRHCRTKCGEEKLPREESRPMECKCC 137
            :||:|.|...|         .|||.|.:||..:...:..:.|.....||        :|.||:.|
Mouse   213 QLTRHQKSHSG---------EKPFECNECGKAFHLPDLLKYHKTIHTGE--------KPFECREC 260

  Fly   138 YTRFSSASNLSKHRRSRPDT-------CGQPEYDSPGSSDGMKKHKAFRKKDRNRDSDDEDTTSE 195
            ...|:..|||..||....|.       ||                |||::  |:.....:.|.|:
Mouse   261 GKSFNRVSNLVAHRIIHADVKPYKCSECG----------------KAFKR--RSNLVQHQKTHSD 307

  Fly   196 ESEDSDDDIPLASRLKTKLKQESQNSDSGDECPDFEPNNSEDDADASGFQLPPPAMVKVEAFDEE 260
            |......|......:..:|.:. ||..:|::  .||.:..     ...|:||
Mouse   308 ERPFQCKDCGKGFIVLAQLTRH-QNIHTGEK--SFECHEC-----GKAFRLP------------- 351

  Fly   261 DFEYQDASMYVKTESTDIFSNEKDKLLDVLLNEGDGLKPFESLKVEQGAGILDEIAAVPLVEVAE 325
                |..:.:.|:.|                    |.|||:..:..:...:.|.:.....:
Mouse   352 ----QQLTRHQKSHS--------------------GEKPFKCNECGKAFHLPDLLKYHKTI---- 388

  Fly   326 EDVLELRGHQMEKPPGPRKRGRPPKEKIPVVKRKYRKRNAPRSPSPDDSSGTPKRVAKISKKELK 390
                    |...||...|:.|:.......:|  ::|..:|...|...:..|   :..|.||..::
Mouse   389 --------HTSTKPFECRECGKSFHRISNLV--EHRLIHADVKPHKCNECG---KAFKRSKSLMQ 440

  Fly   391 ERLKMINKMEKSWKCPHCVKIY----HIRKPYEKHLRD-DHKLNEAEMK-----EIFKDVDVHAK 445
            .  :.|:..|:.::|..|.|.:    |:.:....|..: ..:.||...|     .:.....:|.
Mouse   441 H--QKIHSGERPFQCQECGKAFIVLTHLTRHQTIHTGEKSFECNECGKKFRTATHLVMHQTIHT- 502

  Fly   446 LDEEVFKCPICSKIYLVEKRLVTHMKVHGEDGKLTFKCPCYCNLFFATKEQATEHARAQHKELLY 510
             .|:.|:|.:|.|.:.::..|..|.|:|.|:  ..|||. .|...|..|.|..||
Mouse   503 -GEKPFECNVCGKAFRLQVYLSEHQKIHIEE--KPFKCK-LCGSAFRRKYQLNEH---------- 553

  Fly   511 CEKCDKYMTGHDSLKNHERNFHSKKEPRSQQRNLICDKCGKKFTGRTSLSDHVRSDCGRLPLYGC 575
                              ...|:.::|..      |.:|||.|..|::.::|.....|..| :.|
Mouse   554 ------------------YTIHTDEKPYQ------CKECGKCFRQRSNFTEHQSIHTGNKP-FEC 593

  Fly   576 SVCGKHLSTAGILKTHMLLHKADTPYQCDKCGKTFKVKAQYKSHLKTRHTDYKPYKCHLCPKEYP 640
            ..|||......:|..|...|.::.||:|.:|||.|.:.::..:| :..||..:|::|.:|.|.:.
Mouse   594 KECGKFFRLNTLLIRHQKSHSSERPYKCKECGKAFHLPSELNNH-QIVHTSNRPFECKVCGKSFK 657

  Fly   641 YRESLLTHMTVHTGIKRFLCNNCGKRFTCISNLQAHRKVHAD-------TCGQ-LPLNAKATQYM 697
            ...:|:.|..:|.|:|.:.||.|||.|...|:|..|||:|:|       .||: ..:.|..|::.
Mouse   658 RESTLIQHSVIHGGVKSYECNECGKAFIHRSSLFHHRKIHSDEKPFKCQECGKAFVVLAYLTRHQ 722

  Fly   698 GVQRGK 703
            .:..|:
Mouse   723 SIHTGE 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zf30C	NP_477301.1	C2H2 Zn finger	33..53	CDD:275368	4/19 (21%)
		C2H2 Zn finger	61..82	CDD:275368	7/20 (35%)
		C2H2 Zn finger	98..117	CDD:275368	4/18 (22%)
		C2H2 Zn finger	134..152	CDD:275368	7/17 (41%)
		C2H2 Zn finger	511..532	CDD:275370	0/20 (0%)
		COG5048	<523..>672	CDD:227381	43/148 (29%)
		C2H2 Zn finger	546..566	CDD:275368	7/19 (37%)
		C2H2 Zn finger	575..595	CDD:275368	6/19 (32%)
		C2H2 Zn finger	603..624	CDD:275368	6/20 (30%)
		C2H2 Zn finger	632..652	CDD:275368	5/19 (26%)
		C2H2 Zn finger	660..680	CDD:275368	11/19 (58%)
Zfp780b	NP_001074490.1	KRAB	14..75	CDD:214630
		C2H2 Zn finger	173..193	CDD:275368	4/19 (21%)
		COG5048	197..605	CDD:227381	114/546 (21%)
		C2H2 Zn finger	201..221	CDD:275368	7/19 (37%)
		C2H2 Zn finger	229..249	CDD:275368	4/19 (21%)
		C2H2 Zn finger	257..277	CDD:275368	8/19 (42%)
		C2H2 Zn finger	285..305	CDD:275368	6/37 (16%)
		C2H2 Zn finger	313..333	CDD:275368	4/20 (20%)
		C2H2 Zn finger	341..361	CDD:275368	5/41 (12%)
		C2H2 Zn finger	369..389	CDD:275368	1/31 (3%)
		C2H2 Zn finger	397..417	CDD:275368	4/21 (19%)
		C2H2 Zn finger	425..445	CDD:275368	4/24 (17%)
		C2H2 Zn finger	453..473	CDD:275368	4/19 (21%)
		C2H2 Zn finger	481..501	CDD:275368	3/19 (16%)
		C2H2 Zn finger	509..529	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	7/48 (15%)
		C2H2 Zn finger	565..585	CDD:275368	7/19 (37%)
		C2H2 Zn finger	593..613	CDD:275368	6/19 (32%)
		C2H2 Zn finger	621..641	CDD:275368	6/20 (30%)
		C2H2 Zn finger	649..669	CDD:275368	5/19 (26%)
		C2H2 Zn finger	677..697	CDD:275368	11/19 (58%)
		C2H2 Zn finger	705..725	CDD:275368	4/19 (21%)
		C2H2 Zn finger	733..753	CDD:275368
		C2H2 Zn finger	761..781	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000