DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zf30C and hang

DIOPT Version :9

Sequence 1:	NP_477301.1	Gene:	zf30C / 34292	FlyBaseID:	FBgn0270924	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster

Alignment Length:	990	Identity:	182/990 - (18%)
Similarity:	296/990 - (29%)	Gaps:	352/990 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 CPVCNKALVSLAGYVKHVKKHQP--PGG--FEC-----------RHCDARFC------------- 69
            |..|||...:...::.||:|..|  |..  |.|           .|...|.|
  Fly   713 CRCCNKYFSTYKNFMAHVRKKYPQLPRNLCFNCLKMNDSKALFISHLKKRNCINLFRVLNALRGK 777

  Fly    70 HEEELTQHAKD--EHGVTGAV---------------------------AGQER------------ 93
            ....:...|.|  :.|.||::                           .|.||
  Fly   778 TTTVVVPIADDVADDGATGSIPVADAGAGVVAMNSPTVTASGEVVTPGGGSERPEKLRAKELLVN 842

  Fly    94 KPFVCEKCGAEYKYQEAYRRHCRTKCGEEKLPREESRPMECKCCYTRFSSASNLSKHR------- 151
            |.:.|:.|...::.:..:|.|...|..:  :.|:::..::|..|...|:...:..:|.
  Fly   843 KLYECKLCPKGFRTKHEFRTHVYDKHAD--VQRKDNNSIQCSFCGLDFADPVDRRRHYNNMDCIV 905

  Fly   152 RSRPDTC------------------------GQPEYDSPGSSDGMKKHKAFRKKDRNRD---SDD 189
            |.|..||                        |....::..:..||.:..:.......|.   :..
  Fly   906 RLRCMTCDAKLETHQRFLDHVYQDHLGGVGGGAVSDNASTTGSGMARSNSMEHSPGKRSLLGALG 970

  Fly   190 EDTTSEESEDSDDDIPLASRLK-----------------TKLKQESQNSDSG-----------DE 226
            ..:::|||..|....||.|..|                 ....|.|.|.|:.           ..
  Fly   971 VGSSAEESRSSSAAPPLTSTPKLAGGNQVGGGGSTSASAAAAAQSSANRDASAPKSQYFSRMPQV 1035

  Fly   227 CP-----------------DFEPNNSEDDADASGFQLPPPA-------MVKVEAFDEE----DFE 263
            ||                 ...||...:........|..|.       |:.|...|:.    .||
  Fly  1036 CPICGQQYNNYNNVLRHMESKHPNKLPETYKCVRCGLGYPRISYLREHMINVHGVDKNRHSGGFE 1100

  Fly   264 Y---QDASMYVKTESTDIFSNEKDKLLDVLLNEGDGLKPFESLKVEQGA---------------- 309
            |   .||.......:.::::...|.::..|::..:| ...:..:.|.|:
  Fly  1101 YIVNADAVKLADGSTPNVYTGRYDYVMKDLMSITNG-GTLDDEEEEPGSVAKKMRLDDSSNNSSL 1164

  Fly   310 -GILDEIAAVPLVEVAEEDVLELRGHQ---------MEKPPGPRKRGRPPKEKI---PVVKRKY- 360
             |:..:....|:......:.:.|..|.         :........|..|....|   |....:.
  Fly  1165 VGVASQQKECPICNAVFSNNIGLSNHMRSHYTASNAVNAALAAANRMTPKSLTITATPATDSELG 1229

  Fly   361 ----RKRNAPRSPS---PDDSSGTPKRVAKISKKELKERLKMINKMEKSWKCPHCVKIYHIRKPY 418
                ...:||.:|:   |..::.||:..| :.::.|.:   ..::..:..:|..|.:.:..:|.|
  Fly  1230 VGGTMSESAPATPANVPPAMANQTPQEQA-VFRRSLDQ---AADRRFRRMRCRICQRRFSSKKSY 1290

  Fly   419 EKHLRDDH----------KLNEAEMK-------EIFKDVDVHAKL--DEEV---FKCPICSKIYL 461
            ..|:..||          ||..||..       .:||   ||.|.  ||.:   |:|.:||.:|.
  Fly  1291 RYHMLTDHQVQNVQFIKCKLCNAEFAYEKGLKVHLFK---VHGKAIKDEMIIKQFECDVCSIVYS 1352

  Fly   462 VEKRLVTHMK-VHG----------------------EDGKLT----------------------- 480
            .|..|..|.: ||.                      :|||.|
  Fly  1353 SESELQQHKRSVHKLTSASASTSASTSSKIDDDSLMDDGKPTSSDLADLSTLAAGGSTASAPLYW 1417

  Fly   481 FKCPCYCNLFFATKEQATEHARAQHKEL----LYCEKCDKYMTGHDSLKNHERNFHSKKEPRSQQ 541
            ::|. ||...|.|.::...|..: |.|.    ..|:.|....:|..||..|....|.:....::
  Fly  1418 YQCK-YCPSNFNTNKKLAIHINS-HDEFDSNDYSCKDCGNVYSGRKSLWVHRYKKHPQVPNPAE- 1479

  Fly   542 RNLICDKCGKKFTGRTSLSDHVRSDCGRLPLYGCSVCGKHLSTAGILKTH------MLLHKA--- 597
                |..|.|.|..|....:|..: |.|.|:   :..|.|....|.|.:|      :..||.
  Fly  1480 ----CSLCRKVFFDRQMHDNHTPT-CNRKPI---TSTGAHQQQDGQLHSHHTAKRTIFRHKTGDD 1536

  Fly   598 ------DTPYQ------CDKCGKTFKV----KAQYKSHLKTRHTDYKPYKCHLCPKEYPYRESLL 646
                  |...|      .|..|.|..|    .|...:.||.|..:   ..|.:|...:..:|...
  Fly  1537 DDEEDDDEQQQLEERANSDGNGTTVGVASGSTAAAGTSLKIRIPE---VACTICGARFTDQEHFS 1598

  Fly   647 THMTVHT-----------------------GIKR------FLCNNCGKRFTCISNLQAHRKVH-- 680
            .|:..|.                       .::|      :.|:.|.|.|..:..|:.|||.|
  Fly  1599 KHIQKHEQELYVDNPLAAMFDDGPADAGQFQVERQNENGEYACDLCAKTFPQVIALKVHRKWHFR 1663

  Fly   681 ADTCGQLPLNAKATQ 695
            .|: .|.|::.:|||
  Fly  1664 GDS-KQNPIDGEATQ 1677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zf30C	NP_477301.1	C2H2 Zn finger	33..53	CDD:275368	6/19 (32%)
		C2H2 Zn finger	61..82	CDD:275368	6/46 (13%)
		C2H2 Zn finger	98..117	CDD:275368	4/18 (22%)
		C2H2 Zn finger	134..152	CDD:275368	4/24 (17%)
		C2H2 Zn finger	511..532	CDD:275370	6/20 (30%)
		COG5048	<523..>672	CDD:227381	40/202 (20%)
		C2H2 Zn finger	546..566	CDD:275368	6/19 (32%)
		C2H2 Zn finger	575..595	CDD:275368	5/25 (20%)
		C2H2 Zn finger	603..624	CDD:275368	7/24 (29%)
		C2H2 Zn finger	632..652	CDD:275368	4/19 (21%)
		C2H2 Zn finger	660..680	CDD:275368	8/19 (42%)
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368	2/20 (10%)
		C2H2 Zn finger	1067..1088	CDD:275368	3/20 (15%)
		C2H2 Zn finger	1279..1298	CDD:275371	4/18 (22%)
		C2H2 Zn finger	1308..1325	CDD:275371	4/16 (25%)
		C2H2 Zn finger	1420..1440	CDD:275368	6/21 (29%)
		C2H2 Zn finger	1450..1468	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455442
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930