DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zf30C and CG8944

DIOPT Version :9

Sequence 1:	NP_477301.1	Gene:	zf30C / 34292	FlyBaseID:	FBgn0270924	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_573065.1	Gene:	CG8944 / 32517	FlyBaseID:	FBgn0030680	Length:	762	Species:	Drosophila melanogaster

Alignment Length:	823	Identity:	149/823 - (18%)
Similarity:	261/823 - (31%)	Gaps:	300/823 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 HEEELTQHAKDEHGVTGAVAGQERKPFVCEKCGAEYKYQEAYRRHCRT-KCGEEKLPREESR--- 130
            ::||:.:|...:.|:..|....:.....|..|..::.|.:::..|.:| ..|::.:....||
  Fly    10 NDEEIFRHCTKDCGMVTATDDFQYFALRCIFCSEKFLYFDSFIGHMQTVHLGDQSVANTSSRLPF 74

  Fly   131 ----PMECKCCYTRFSSASNLSKHRRSRP-----------DTC--------GQPEYDSPGSSDGM 172
                ||             :||......|           ||.        .|...|.|.|.|.:
  Fly    75 NLGEPM-------------SLSGRNGDLPNFHEIEDLTDADTALLEPQMVIKQELQDLPCSDDDV 126

  Fly   173 KKHKAFRKKDRNRDSDDEDTTSEESEDSDD------DIPLAS-----RLK-TKLKQESQNS---- 221
            .         ...:.|||...::...|.|:      |:|:.|     |.| ||.:|...:|
  Fly   127 V---------AGEEDDDEQRLNDSEADEDEAILPESDVPVVSSKTRARKKVTKQRQRDMSSELLI 182

  Fly   222 ---------DSGDECPDFEPNNSEDDADASGFQLPPPAMVKVEAF-DEEDF-EY----------- 264
                     |.||....:..:||.:..|.:||.     .|....| .|.|| .|
  Fly   183 AGDGDSSMDDYGDPDHSYMDDNSGEYMDFAGFD-----GVNHSGFGTESDFLSYDEMVEESLLGR 242

  Fly   265 -QDASMYVK-------------------------------------------------------- 272
             ::.:|::|
  Fly   243 DREVTMHIKDRKMIQFLIHSYQRNPFLWDHGNAQFRDRVKRARFLDWIVLEFKSRFNISLAKDAI 307

  Fly   273 -------------------TESTDI----------FSNE----KDKLLDVLLNEGDGLKPFESL- 303
                               .|.|:|          |.||    .||:.|.::.|....:.|.::
  Fly   308 TRKWDNLRTVYKRECNRMALEKTNISTLWYFKELHFLNEVYSYNDKMSDAVVKETSYRRRFSAIW 372

  Fly   304 ----------------------------KVEQGAGILDEIAAVPLVEVAEEDVLELRGHQMEKPP 340
                                        |..:|.|:  ...|:.|.::.:...:::
  Fly   373 NDTSTAKLLSMVKRYQCFYNRFDPDYRSKERRGEGL--HQMAIELQQLIDVTTIQI--------- 426

  Fly   341 GPRKRGRPPKEKIPVVKRKYRKRNAPRSPSPDDSSGTPKRVAK--ISKKELKERLKMINKMEKSW 403
                     .::|..::..|.|:...|..|        :|:.|  |:.....:::..::.....:
  Fly   427 ---------SKRISQLRFDYSKQKMERLNS--------ERLGKKFIANYLYYDQMHFMDDDIPPF 474

  Fly   404 KCPHCVKIYHIRKPYEKHLRDDHKLNEAEMKEIFKDVDVHAKLDEEV----FKCPICSKIYLVEK 464
            ||.||                      .|:.:..:::|:|....:..    :.|.|||..:...:
  Fly   475 KCAHC----------------------PEIVQTLRELDLHMLTHQPSLGGGYYCNICSIQFHNAQ 517

  Fly   465 RLVTHMKVH-GEDGKLTFKCPCYCNLFFATKEQATEHARAQHKELLYCEKCDKYMTGHDSLKNHE 528
            ....|.::| |...::.|.|. .|...|..|....||.|..::||........:......|.:.|
  Fly   518 EFDNHKQLHLGGVTEIKFNCE-LCTASFREKANYDEHLRRHNEELFLPSLALNHSIMEGGLGDDE 581

  Fly   529 RNFHSKKEPRSQQRNLICDKCGKKFTGRTSLSDHVRSDCGRL-----------------PLYGCS 576
            .....::...|..|        :|.......:|.:..|..|:                 | |||.
  Fly   582 IGVEGEESRGSGSR--------RKRRHAAKATDDMVDDDDRIGGGGGGGSGGGGTDIAKP-YGCD 637

  Fly   577 VCGKHLSTAGILKTHMLLHKADTP--YQCD--KCGKTFKVKAQYKSHLKTRHTDYKPYKCHLCPK 637
            ||.:..:|.|.|..|.::|:.:..  |:||  :|.|:|..:.....||| :|...:.:||.:|.|
  Fly   638 VCRRSFATPGHLNAHRIVHQDERERCYKCDYPQCNKSFVARNSLFEHLK-QHYSNEEFKCDICGK 701

  Fly   638 EYPYRESLLTHMTVHTGIKRFLCNNCGKRFTCISNLQAHRKVH 680
            .:...::|..|..:|..|||::|..||..|...:.|..|::.|
  Fly   702 TFKSTKNLQNHKQIHDKIKRYVCQICGSAFAQAAGLYLHKRRH 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zf30C	NP_477301.1	C2H2 Zn finger	33..53	CDD:275368
		C2H2 Zn finger	61..82	CDD:275368	3/11 (27%)
		C2H2 Zn finger	98..117	CDD:275368	4/18 (22%)
		C2H2 Zn finger	134..152	CDD:275368	2/17 (12%)
		C2H2 Zn finger	511..532	CDD:275370	2/20 (10%)
		COG5048	<523..>672	CDD:227381	43/169 (25%)
		C2H2 Zn finger	546..566	CDD:275368	2/19 (11%)
		C2H2 Zn finger	575..595	CDD:275368	7/19 (37%)
		C2H2 Zn finger	603..624	CDD:275368	8/22 (36%)
		C2H2 Zn finger	632..652	CDD:275368	5/19 (26%)
		C2H2 Zn finger	660..680	CDD:275368	6/19 (32%)
CG8944	NP_573065.1	MADF_DNA_bdg	259..344	CDD:287510	3/84 (4%)
		MADF	379..472	CDD:214738	13/120 (11%)
		C2H2 Zn finger	476..496	CDD:275368	6/41 (15%)
		C2H2 Zn finger	506..526	CDD:275368	5/19 (26%)
		C2H2 Zn finger	537..557	CDD:275368	7/20 (35%)
		C2H2 Zn finger	636..656	CDD:275368	7/19 (37%)
		zf-C2H2_8	639..712	CDD:292531	21/73 (29%)
		C2H2 Zn finger	666..688	CDD:275368	8/22 (36%)
		zf-C2H2	694..716	CDD:278523	6/21 (29%)
		C2H2 Zn finger	696..716	CDD:275368	5/19 (26%)
		zf-H2C2_2	708..733	CDD:290200	10/24 (42%)
		C2H2 Zn finger	724..744	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455441
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930