Protein Alignment zf30C and ZNF48

DIOPT Version :10

• Sequence 1: NP_477301.1
• Gene: zf30C / 34292
• FlyBaseID: FBgn0270924
• Length: 777
• Species: Drosophila melanogaster
• Sequence 2: NP_689865.2
• Gene: ZNF48 / 197407
• HGNCID: 13114
• Length: 618
• Species: Homo sapiens
• Alignment Length: 408
• Identity: 94/408 - (23%)
• Similarity: 140/408 - (34%)
• Gaps: 124/408 - (30%)

  Fly   419 EKHLRDDHKLNEAEMK----EIFKDVDVHAK-----------------------LDEEVFKCPIC 456
            |:.|..||::..|.:|    :.:.|:.|..:                       ..:....|..|
Human    53 EEDLAPDHEVGNASLKPEGIQNWDDLWVQREGLGKPQPRDRGPRLLGEPRWGQASSDRAAVCGEC 117

  Fly   457 SKIYLVEKRLVTHMKVHGEDGKLTFKCPCYCNLFFATKEQATEHARAQHKELLYCEKCDKYMTGH 521
            .|.:.....||.|.:.|  .|:..:||. .|...|.......:|.|..
Human   118 GKSFRQMSDLVKHQRTH--TGEKPYKCG-VCGKGFGDSSARIKHQRTH----------------- 162

  Fly   522 DSLKNHERNFHSK-------KEPRSQ----QRNLICDKCGKKFTGRTSLSDHVRSDCGRLPLYGC 575
                :.|:.:.::       |.|||:    :|..||.:|||.|...:.|..|.|:..|..| |.|
Human   163 ----SGEKPYRARPPAQGPPKIPRSRIPAGERPTICGECGKSFRQSSDLVKHQRTHTGEKP-YKC 222

  Fly   576 SVCGKHLSTAGILKTHMLLHKA---------------------------DTPYQCDKCGKTFKVK 613
            .:|||....:.....|...|:.                           |.||.|..|||.|.:.
Human   223 GICGKGFGDSSARIKHQRTHRGEQPPRPVVPRRQPSRAATAATQGPKAQDKPYICTDCGKRFVLS 287

  Fly   614 AQYKSHLKTRHTDYKPYKCHLCPKEYPYRESLLTHMTVHTGIKRFLCNNCGKRFTCISNLQAHRK 678
            ....||.:: |...||:.|.:|.||:.....|:.|:.||||.|.:||..|||.|...|....|.:
Human   288 CSLLSHQRS-HLGPKPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLCPECGKGFADSSARVKHLR 351

  Fly   679 VHADTCGQLPLNAKATQYMGVQRGKLLMGAKPEAGMEYEETKTLIAQDVIDRDMPMAQELNF--- 740
            .|:   |:.|                  .|.||....:..:.||:...:...:   .|:.:|
Human   352 THS---GERP------------------HACPECDRTFSLSSTLLRHRLTHME---PQDFSFPGY 392

  Fly   741 ------PSDGSAPLATVP 752
                  ||....||.|.|
Human   393 PLPALIPSPPPPPLGTSP 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zf30C	NP_477301.1	C2H2 Zn finger	33..53	CDD:275368
		C2H2 Zn finger	61..82	CDD:275368
		C2H2 Zn finger	98..117	CDD:275368
		C2H2 Zn finger	134..152	CDD:275368
		C2H2 Zn finger	511..532	CDD:275370	1/20 (5%)
		COG5048	<523..>672	CDD:227381	54/186 (29%)
		C2H2 Zn finger	546..566	CDD:275368	8/19 (42%)
		C2H2 Zn finger	575..595	CDD:275368	5/19 (26%)
		C2H2 Zn finger	603..624	CDD:275368	7/20 (35%)
		C2H2 Zn finger	632..652	CDD:275368	6/19 (32%)
		C2H2 Zn finger	660..680	CDD:275368	7/19 (37%)
ZNF48	NP_689865.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..51
		SFP1	<51..215	CDD:227516	37/185 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..109		1/30 (3%)
		C2H2 Zn finger	114..134	CDD:275368	6/19 (32%)
		zf-H2C2_2	126..149	CDD:463886	8/25 (32%)
		C2H2 Zn finger	142..162	CDD:275368	5/20 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..189		7/52 (13%)
		COG5048	190..599	CDD:227381	67/247 (27%)
		C2H2 Zn finger	194..214	CDD:275368	8/19 (42%)
		C2H2 Zn finger	222..242	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	235..271		2/35 (6%)
		C2H2 Zn finger	277..297	CDD:275368	7/20 (35%)
		C2H2 Zn finger	305..325	CDD:275368	6/19 (32%)
		C2H2 Zn finger	333..353	CDD:275368	7/19 (37%)
		C2H2 Zn finger	361..381	CDD:275368	4/19 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	392..457		6/19 (32%)
		C2H2 Zn finger	453..473	CDD:275368
		C2H2 Zn finger	481..501	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	500..540
		C2H2 Zn finger	545..565	CDD:275368
		C2H2 Zn finger	573..593	CDD:275370