Protein Alignment zf30C and ZNF689

DIOPT Version :10

• Sequence 1: NP_477301.1
• Gene: zf30C / 34292
• FlyBaseID: FBgn0270924
• Length: 777
• Species: Drosophila melanogaster
• Sequence 2: NP_612456.1
• Gene: ZNF689 / 115509
• HGNCID: 25173
• Length: 500
• Species: Homo sapiens
• Alignment Length: 378
• Identity: 98/378 - (25%)
• Similarity: 151/378 - (39%)
• Gaps: 42/378 - (11%)

  Fly   332 RGHQMEKPPGPRKRGR-----PPKEKIPVVKRKYRKRNAPRSPS--PDDSSG---TPKRVAKISK 386
            ||..:::....||:..     ||||    ..||.::...|..|.  |..:||   .|........
Human   100 RGLTVQRKSRTRKKNGEKEVFPPKE----APRKGKRGRRPSKPRLIPRQTSGGPICPDCGCTFPD 160

  Fly   387 KELKERLKMINKMEKSWKCPHCVKIYHIRKPYEKHLR----------DDHKLNEAEMKEIFKDVD 441
            .:..|..|....::|.:.||.|.:.:........|.|          |......::.|.:.:...
Human   161 HQALESHKCAQNLKKPYPCPDCGRRFSYPSLLVSHRRAHSGECPYVCDQCGKRFSQRKNLSQHQV 225

  Fly   442 VHAKLDEEVFKCPICSKIYLVEKRLVTHMKVHGEDGKLTFKCPCYCNLFFATKEQATEHARAQHK 506
            :|.  .|:.:.||.|.:.:...:.|..|...|  .|:...:||. |...||.......|.|....
Human   226 IHT--GEKPYHCPDCGRCFRRSRSLANHRTTH--TGEKPHQCPS-CGRRFAYPSLLAIHQRTHTG 285

  Fly   507 ELLY-CEKCDKYMTGHDSLKNHERNFHSKKEPRSQQRNLICDKCGKKFTGRTSLSDHVRSDCGRL 570
            |..| |.:|::......:|..|:| .|:.::|..      |..|.::|:..:.|..|.|...|..
Human   286 EKPYTCLECNRRFRQRTALVIHQR-IHTGEKPYP------CPDCERRFSSSSRLVSHRRVHSGER 343

  Fly   571 PLYGCSVCGKHLSTAGILKTHMLLHKADTPYQCDKCGKTFKVKAQYKSHLKTRHTDYKPYKCHLC 635
            | |.|..|....|....|..|.|||..:.||.|..||:.|:.......|..| ||:.|.:.|..|
Human   344 P-YACEHCEARFSQRSTLLQHQLLHTGEKPYPCPDCGRAFRRSGSLAIHRST-HTEEKLHACDDC 406

  Fly   636 PKEYPYRESLLTHMTVHTGIKRFLCNNCGKRFTCISNLQAHRKVHADTCGQLP 688
            .:.:.|...|.:|..||:|.:.:.|:.|.|||...|:|..|:.:|.   |:.|
Human   407 GRRFAYPSLLASHRRVHSGERPYACDLCSKRFAQWSHLAQHQLLHT---GEKP 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zf30C	NP_477301.1	C2H2 Zn finger	33..53	CDD:275368
		C2H2 Zn finger	61..82	CDD:275368
		C2H2 Zn finger	98..117	CDD:275368
		C2H2 Zn finger	134..152	CDD:275368
		C2H2 Zn finger	511..532	CDD:275370	5/20 (25%)
		COG5048	<523..>672	CDD:227381	46/148 (31%)
		C2H2 Zn finger	546..566	CDD:275368	6/19 (32%)
		C2H2 Zn finger	575..595	CDD:275368	6/19 (32%)
		C2H2 Zn finger	603..624	CDD:275368	6/20 (30%)
		C2H2 Zn finger	632..652	CDD:275368	5/19 (26%)
		C2H2 Zn finger	660..680	CDD:275368	8/19 (42%)
ZNF689	NP_612456.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		KRAB	29..88	CDD:214630
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..146		13/49 (27%)
		C2H2 Zn finger	151..171	CDD:275368	3/19 (16%)
		COG5048	159..>466	CDD:227381	82/315 (26%)
		C2H2 Zn finger	179..199	CDD:275368	5/19 (26%)
		C2H2 Zn finger	207..227	CDD:275368	2/19 (11%)
		C2H2 Zn finger	235..255	CDD:275368	5/19 (26%)
		C2H2 Zn finger	263..283	CDD:275368	7/20 (35%)
		C2H2 Zn finger	291..311	CDD:275368	5/20 (25%)
		C2H2 Zn finger	319..339	CDD:275368	6/19 (32%)
		C2H2 Zn finger	347..367	CDD:275368	6/19 (32%)
		C2H2 Zn finger	375..395	CDD:275368	6/20 (30%)
		C2H2 Zn finger	403..423	CDD:275368	5/19 (26%)
		C2H2 Zn finger	431..451	CDD:275368	8/19 (42%)
		C2H2 Zn finger	459..475	CDD:275368