DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zf30C and LOC102546648

DIOPT Version :9

Sequence 1:	NP_477301.1	Gene:	zf30C / 34292	FlyBaseID:	FBgn0270924	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	XP_008757662.1	Gene:	LOC102546648 / 102546648	RGDID:	7541917	Length:	883	Species:	Rattus norvegicus

Alignment Length:	691	Identity:	162/691 - (23%)
Similarity:	242/691 - (35%)	Gaps:	190/691 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 CPVCNKALVSLAGYVKHVKKHQPPGGFECRHCDARFCHEEELTQHAKDEHGVTGAVAGQERKPFV 97
            ||.|.|:....:....|.:.|.....:|||.|...|.:..:|..|.:...|         .:|:|
  Rat   326 CPDCGKSFSRTSNLQVHHRIHTGEKPYECRDCGKSFNNTSQLKVHYRIHTG---------ERPYV 381

  Fly    98 CEKCGAEYKYQEAYRRHCRTKCGEEKLPREESRPMECKCCYTRFSSASNLSK----HRRSRPDTC 158
            |..||..:|.:.....|.....||        :|.:|..|...||..|.|..    |.:.:|..|
  Rat   382 CPVCGKAFKQKSILSTHETIHTGE--------KPYKCTVCGKLFSCTSRLKVHYQIHMKEKPYEC 438

  Fly   159 GQPEYDSPGSSDGMKKHKAFRKKDRNRDSDDEDTTSEESEDSDDDIPLASRLKTKLKQES-QNSD 222
            |.             ..|||::|                          |.|....|..| |...
  Rat   439 GD-------------CGKAFKRK--------------------------SSLTVHQKIHSRQTRH 464

  Fly   223 SGDECPDFEPNNSEDDADASGFQLPPPAMVKVEAFDEEDFEYQDASMYVKTESTDIFSNEKDKLL 287
            :..||.......||                                  :.|...........|..
  Rat   465 ACSECGKEFSQKSE----------------------------------LSTHQRLHLGKNSHKCA 495

  Fly   288 DVLLNEGDGLKPFESLKVEQGAGILDEIAAVPLVEVAEEDVLELRGHQMEKPPGPRKRGRPPKEK 352
            |.    |........||:..                        |.|..|||
  Rat   496 DC----GKAFTYASQLKMHH------------------------RVHTGEKP------------- 519

  Fly   353 IPVVKRKYRKRNAPRSPSPDDSSGTPKRVAKI--------------SKKELKERLKMINKMEKSW 403
                   |:.|:..:|.:...:....:|:.|:              ||.:|:|. :.|:..||.:
  Rat   520 -------YKCRDCGKSFTYSFTLNVHRRIHKVEKPHKCSVCGKALASKYQLEEH-ERIHTGEKPY 576

  Fly   404 KCPHCVKIYHIRKPYEK----HLRDD----HKLNEA--EMKEIFKDVDVHAKLDEEVFKCPICSK 458
            .|..|.|.:|.|..:.:    |.||.    ||..:|  :..::......|.  .|:.:.|..|.|
  Rat   577 VCTECGKGFHGRSGFLRHQITHTRDKPFVCHKCGKAFFQRSQLTSHQQTHT--GEKPYPCRYCGK 639

  Fly   459 IYLVEKRLVTHMKVHGEDGKLTFKCPCYCNLFFATKEQATEHARAQHKELLY-CEKCDKYMTGHD 522
            .:....:|..|.::|  .|:..:||. ||...|:...|..||.|....|..| |.:|.|..:...
  Rat   640 SFSHTSQLTVHHRIH--TGERPYKCN-YCGKSFSNSSQLKEHLRIHTGETPYACSECGKAFSRRS 701

  Fly   523 SLKNHERNFHSKKEPRSQQRNLICDKCGKKFTGRTSLSDHVRSDCGRLPLYGCSVCGKHLSTAGI 587
            ||     |.|:|  ..:.:::.||.:|||.|:.::.|..|.|...|..| |.|..|||.|::.|.
  Rat   702 SL-----NLHTK--IHTGEKHHICSECGKAFSQKSVLRTHQRIHTGEKP-YKCGDCGKALASKGQ 758

  Fly   588 LKTHMLLHKADTPYQCDKCGKTFKVKAQYKSHLKTRHTDYKPYKCHLCPKEYPYRESLLTHMTVH 652
            |:.|..:|..:.||.|.:|||.|..::....|..| ||..:|:.|..|.|.:..:.:|.:|..:|
  Rat   759 LRDHQRIHTGEKPYVCPECGKGFFGRSSLHRHQMT-HTKERPFVCQKCGKTFIQKSALTSHQQIH 822

  Fly   653 TGIKRFLCNNCGKRFTCISNLQAHRKVH-------ADTCGQ 686
            ||.|.::|..|||.|...|:|..|:..|       ...||:
  Rat   823 TGEKPYVCPECGKGFYNKSSLPRHQMTHTKGRSFVCQKCGK 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zf30C	NP_477301.1	C2H2 Zn finger	33..53	CDD:275368	5/19 (26%)
		C2H2 Zn finger	61..82	CDD:275368	6/20 (30%)
		C2H2 Zn finger	98..117	CDD:275368	5/18 (28%)
		C2H2 Zn finger	134..152	CDD:275368	7/21 (33%)
		C2H2 Zn finger	511..532	CDD:275370	6/20 (30%)
		COG5048	<523..>672	CDD:227381	52/148 (35%)
		C2H2 Zn finger	546..566	CDD:275368	8/19 (42%)
		C2H2 Zn finger	575..595	CDD:275368	8/19 (42%)
		C2H2 Zn finger	603..624	CDD:275368	7/20 (35%)
		C2H2 Zn finger	632..652	CDD:275368	5/19 (26%)
		C2H2 Zn finger	660..680	CDD:275368	8/19 (42%)
LOC102546648	XP_008757662.1	KRAB	23..80	CDD:214630
		C2H2 Zn finger	272..291	CDD:275368
		C2H2 Zn finger	299..319	CDD:275368
		SFP1	<313..400	CDD:227516	21/82 (26%)
		C2H2 Zn finger	326..346	CDD:275368	5/19 (26%)
		C2H2 Zn finger	354..374	CDD:275368	6/19 (32%)
		COG5048	378..813	CDD:227381	131/578 (23%)
		C2H2 Zn finger	382..402	CDD:275368	5/19 (26%)
		C2H2 Zn finger	410..430	CDD:275368	6/19 (32%)
		C2H2 Zn finger	438..458	CDD:275368	9/58 (16%)
		C2H2 Zn finger	466..486	CDD:275368	5/53 (9%)
		C2H2 Zn finger	494..514	CDD:275368	5/47 (11%)
		C2H2 Zn finger	522..542	CDD:275368	3/19 (16%)
		C2H2 Zn finger	550..570	CDD:275368	4/20 (20%)
		C2H2 Zn finger	578..598	CDD:275368	5/19 (26%)
		C2H2 Zn finger	606..626	CDD:275368	3/19 (16%)
		C2H2 Zn finger	634..654	CDD:275368	5/19 (26%)
		C2H2 Zn finger	662..682	CDD:275368	8/20 (40%)
		C2H2 Zn finger	690..710	CDD:275368	8/26 (31%)
		C2H2 Zn finger	718..738	CDD:275368	8/19 (42%)
		C2H2 Zn finger	746..766	CDD:275368	8/19 (42%)
		C2H2 Zn finger	774..794	CDD:275368	7/20 (35%)
		COG5048	796..>869	CDD:227381	21/68 (31%)
		C2H2 Zn finger	802..822	CDD:275368	5/19 (26%)
		C2H2 Zn finger	830..850	CDD:275368	8/19 (42%)
		C2H2 Zn finger	858..878	CDD:275368	2/6 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000