DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zf30C and LOC100365363

DIOPT Version :9

Sequence 1:	NP_477301.1	Gene:	zf30C / 34292	FlyBaseID:	FBgn0270924	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	XP_006228060.2	Gene:	LOC100365363 / 100365363	RGDID:	2319215	Length:	670	Species:	Rattus norvegicus

Alignment Length:	790	Identity:	161/790 - (20%)
Similarity:	247/790 - (31%)	Gaps:	299/790 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 METESMAPSSSAAAAATKLLVEITTDGIPKLH-----------------------CPVCNKALVS 42
            ||.:|::..||..::..   :.::.|..|.:|                       |..|:|....
  Rat    96 MEAKSISNGSSILSSDR---IFLSGDKAPFVHEYDVYSSLLMKGQKAAIKEKPYQCNECDKVFRY 157

  Fly    43 LAGYVKHVKKHQPPGGFECRHCDARFCHEEELTQHAKDEHGVTGAVAGQERKPFVCEKCGAEYKY 107
            .:....|.:.|.....::|..|...|.....|..|.:...|.         ||:.|.:||..:..
  Rat   158 TSSLAYHRQIHTGEKLYKCVECGKAFFRRSYLLVHERHHSGA---------KPYKCNECGKVFSQ 213

  Fly   108 QEAYRRHCRTKCGEEKLPREESRPMECKCCYTRFSSASNLSKHRRSRPDTCGQPEYDSPGSSDGM 172
            ....:.|.|...||        :|.:|..|...||..|||:.|
  Rat   214 NSHLKSHRRIHTGE--------KPYKCNDCGKAFSVRSNLTHH---------------------- 248

  Fly   173 KKHKAFRKKDRNRDSDDEDTTSEESEDSDDDIPLASRLKTKLKQESQNSDSGDECPDFEPNNSED 237

  Rat   249 ----------------------------------------------------------------- 248

  Fly   238 DADASGFQLPPPAMVKVEAFDEEDFEYQDASMYVKTESTDIFSNEKDKLLDVLLNEGDGLKPFES 302
                                                               ::::.||  ||:
  Rat   249 ---------------------------------------------------LVIHTGD--KPY-- 258

  Fly   303 LKVEQGAGILDEIAAVPLVEVAEEDVLELRGHQMEKPPGPRKRGRPPKEKIPVVKRKYRKRNAPR 367
             |..:...:..:.:::         .:..|.|..|||                    ||.....:
  Rat   259 -KCNECGKVFSQTSSL---------TIHRRTHTGEKP--------------------YRCNECGK 293

  Fly   368 SPSPDDSSGTPKRVAKISKKELKERLKMINKMEKSWKCPHCVKIY----HIRKPYEKHLRD-DHK 427
            ..|...:..|.               :.|:..||.:||..|.|::    |:...:..|..: .:|
  Rat   294 VFSSHSNLNTH---------------QAIHTGEKPYKCSECGKVFTQNSHLANHWRTHTGEKPYK 343

  Fly   428 LNE-AEMKEIFKDVDVHAKL--DEEVFKCPICSKIYLVEKRLVTHMKVHGEDGKLTFKCPCYCNL 489
            .|| .:...::..:..|..:  .|:.:||..|.|::.....|..|..:|  .|:..:||. .|..
  Rat   344 CNECGKAFSVYSSLTTHLAIHTGEKPYKCEECGKVFTQNSHLANHRGIH--SGEKPYKCE-ECGK 405

  Fly   490 FFATKEQATEHARAQHKELLY-CEKCDKYMTGHDSLKNHERNFHSKKEPRSQQRNLICDKCGKKF 553
            .|........|.|....|..| |.:|.|..:...||.:|: ..|:.::|..      |.:|||.|
  Rat   406 HFNQTSNLARHWRVHTGEKPYKCSECGKAFSVRSSLTSHQ-VIHTGEKPYK------CAECGKVF 463

  Fly   554 TGRTSLSDHVRSDCGRLPLYGCSVCGKHLSTAGILKTHMLLHKADTPYQCDKCGKTFKVKAQYKS 618
            :..:|||.|.|...|..| |.|:.|||..::...|.||.::|....||:|.:|||.|...:...:
  Rat   464 SQTSSLSIHQRIHTGEKP-YRCNECGKAFNSHSNLNTHQVIHTGQKPYKCLECGKVFTQNSHLAN 527

  Fly   619 HLKTRHTDYKPYKCHLCPKEYPYRESLLTHMTVHTGIKRFLCNNCGKRFTCISNLQAHRKVH--- 680
            |.:| ||..|||||:.|.|.:....||.||..:|||.|.|.||.|||.||..|:|.:||:.|
  Rat   528 HHRT-HTGEKPYKCNECGKAFSVYSSLTTHQAIHTGEKPFKCNECGKVFTQNSHLASHRRTHTGE 591

  Fly   681 ----ADTCG--------------------------------QLP---------LNAKATQYMGVQ 700
                ...||                                ::|         ||.|..||..|.
  Rat   592 KPYKCSKCGKAFSVRSSLTTHQAIILEKNLTHVVNVAKSLVEVPTLQVIKDFMLNRKLCQYSKVF 656

  Fly   701 RGKLLMGAKP 710
            |...|:...|
  Rat   657 RHDSLLAQHP 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zf30C	NP_477301.1	C2H2 Zn finger	33..53	CDD:275368	4/19 (21%)
		C2H2 Zn finger	61..82	CDD:275368	5/20 (25%)
		C2H2 Zn finger	98..117	CDD:275368	4/18 (22%)
		C2H2 Zn finger	134..152	CDD:275368	8/17 (47%)
		C2H2 Zn finger	511..532	CDD:275370	6/20 (30%)
		COG5048	<523..>672	CDD:227381	60/148 (41%)
		C2H2 Zn finger	546..566	CDD:275368	10/19 (53%)
		C2H2 Zn finger	575..595	CDD:275368	7/19 (37%)
		C2H2 Zn finger	603..624	CDD:275368	7/20 (35%)
		C2H2 Zn finger	632..652	CDD:275368	7/19 (37%)
		C2H2 Zn finger	660..680	CDD:275368	11/19 (58%)
LOC100365363	XP_006228060.2	KRAB	8..68	CDD:214630
		SFP1	<143..221	CDD:227516	16/86 (19%)
		C2H2 Zn finger	148..168	CDD:275368	4/19 (21%)
		C2H2 Zn finger	176..196	CDD:275368	5/19 (26%)
		COG5048	200..575	CDD:227381	123/581 (21%)
		C2H2 Zn finger	204..224	CDD:275368	5/19 (26%)
		C2H2 Zn finger	232..252	CDD:275368	8/157 (5%)
		C2H2 Zn finger	260..280	CDD:275368	1/28 (4%)
		C2H2 Zn finger	288..308	CDD:275368	2/34 (6%)
		C2H2 Zn finger	316..336	CDD:275368	4/19 (21%)
		C2H2 Zn finger	344..364	CDD:275368	3/19 (16%)
		C2H2 Zn finger	372..392	CDD:275368	5/19 (26%)
		C2H2 Zn finger	400..420	CDD:275368	5/20 (25%)
		C2H2 Zn finger	428..448	CDD:275368	6/20 (30%)
		C2H2 Zn finger	456..476	CDD:275368	10/19 (53%)
		C2H2 Zn finger	484..504	CDD:275368	7/19 (37%)
		C2H2 Zn finger	512..532	CDD:275368	7/20 (35%)
		C2H2 Zn finger	540..560	CDD:275368	7/19 (37%)
		C2H2 Zn finger	568..588	CDD:275368	11/19 (58%)
		zf-H2C2_2	580..604	CDD:404364	6/23 (26%)
		C2H2 Zn finger	596..615	CDD:275368	2/18 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335941
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840