Protein Alignment Cyp4e3 and ERG11

DIOPT Version :10

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_011871.1
• Gene: ERG11 / 856398
• SGDID: S000001049
• Length: 530
• Species: Saccharomyces cerevisiae
• Alignment Length: 501
• Identity: 105/501 - (20%)
• Similarity: 202/501 - (40%)
• Gaps: 85/501 - (16%)

  Fly     8 LLVLPLITLVYFERKASQRRQLLKEFNGPTP------VPILGNANRIGKNPAEILSTFFDWWYDY 66
            ::::|.|..:.:        |||.......|      :|.:|:|...|..|.|.   |.:....|
Yeast    34 IIIIPFIYNIVW--------QLLYSLRKDRPPLVFYWIPWVGSAVVYGMKPYEF---FEECQKKY 87

  Fly    67 GKDNFLFWIGYSSHIVMTNPKQLEYILNSQ--QLIQKSTIYDLLHPWLGHGLLTSF-GSKWHKHR 128
            | |.|.|.:......|...||..|::.|::  .:..::....|..|..|.|::... .|:..:.:
Yeast    88 G-DIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQK 151

  Fly   129 KMITPSFHFNILQDFHEVMNENSAKFMT-----QLKKASAGDTIIDFQEHANYLTLDVICDTAMG 188
            |.:..:......:.:..::.|...|:..     :|.:.:.|  .||.......:|:.....:.:|
Yeast   152 KFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTG--TIDVMVTQPEMTIFTASRSLLG 214

  Fly   189 VPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQK---TLKTLQDFTYDI 250
            ..:.|  :.|:.....:.|:     .:.|.|.   |.||...| ...|:|   ..|.:......:
Yeast   215 KEMRA--KLDTDFAYLYSDL-----DKGFTPI---NFVFPNLP-LEHYRKRDHAQKAISGTYMSL 268

  Fly   251 IEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTI--DGRPLTRQEIYEEVSTFMFEGHDTTT 313
            |::|    :.....:|.|         .:|:|:.::.  ||..:|.|||...:...:..|..|:.
Yeast   269 IKER----RKNNDIQDRD---------LIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSA 320

  Fly   314 SGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIG 378
            :..::.:..|:..||||::||.||..|:... .:.:::..:.:|..|:..|||..|::..:..:.
Yeast   321 ATSAWILLHLAERPDVQQELYEEQMRVLDGG-KKELTYDLLQEMPLLNQTIKETLRMHHPLHSLF 384

  Fly   379 RYCDKDYDINGS--IVPKGTTLNLALILLGY---NDRIFKDPHHFRPERFEEEKPAPFE------ 432
            |...||..:..:  ::|.|..:   |:..||   .|..|.:.|.|...|:.::..:.:.
Yeast   385 RKVMKDMHVPNTSYVIPAGYHV---LVSPGYTHLRDEYFPNAHQFNIHRWNKDSASSYSVGEEVD 446

  Fly   433 -------------YLPFSAGPRNCIGQKFALLELKTVISKVVRSFE 465
                         ||||..|...|||:.||..:|..::|..:|:.:
Yeast   447 YGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLK 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	CYP4	68..519	CDD:410721	90/435 (21%)
ERG11	NP_011871.1	CYP51-like	83..521	CDD:410668	92/441 (21%)