DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e3 and CYP86A4

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_171666.1	Gene:	CYP86A4 / 839347	AraportID:	AT1G01600	Length:	554	Species:	Arabidopsis thaliana

Alignment Length:	586	Identity:	136/586 - (23%)
Similarity:	233/586 - (39%)	Gaps:	146/586 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ALLVLPLIT--LVYFERKASQRRQLLKEFNGPTPVPILGNANRIGKNPAEILSTFFDWWYDYGKD 69
            |:|::.::|  .::|:|       :.:...||...|:||:.      |..|...  |..:::..:
plant     6 AMLLVAIVTGYWLWFKR-------ISRWLKGPRVWPLLGSL------PGLIEQR--DRMHEWITE 55

  Fly    70 NF----------LFWIGYSSH-----IVMTNPKQLEYILNSQ--QLIQKSTIYDLLHPWLGHGLL 117
            |.          :|.:.:.:.     .|..:||.||::|.::  ...:..|...:.|..||.|:.
plant    56 NLRACGGTYQTCIFAVPFLAKKQGLVTVTCDPKNLEHMLKTRFDNYPKGPTWQSVFHDLLGQGIF 120

  Fly   118 TSFGSKWHKHRKMITPSFHFNIL-QDFHEVMNEN-SAKFMTQLKKASAGDTIIDFQEHANYLTLD 180
            .|.|..|...||.....|....| |.....:|.. ..:|...|..|......:|.|:....||.|
plant   121 NSDGDTWLFQRKTAALEFTTRTLRQAMGRWVNRGIKLRFCPILATAQDNAEPVDLQDLILRLTFD 185

  Fly   181 VIC------DT---AMGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFS-- 234
            .||      ||   |.|:|       ::....|| |.....:::.|           :.|:|.
plant   186 NICGLAFGKDTRTCAPGLP-------ENGFASAF-DRATEASLQRF-----------IIPKFMWK 231

  Fly   235 -----------AYQKTLKTLQDFTYDIIEKRVYAL---QNGGSKEDHDPSLPR----KKMAFLDT 281
                       :..::|..:.::...:|..|...|   |..|:.:.||..|.|    |..::.||
plant   232 LKKWLGLGLEVSLSRSLGEIDEYLAAVINTRKQELMSQQESGTHQRHDDLLSRFMMKKTESYSDT 296

  Fly   282 LLSSTIDGRPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVM----G 342
            .|...              ...|:..|.||::..:|:..:|::.||.|:.|:.||.|.|:    |
plant   297 FLQHV--------------ALNFILAGRDTSSVALSWFFWLITMHPTVEDKIVREICSVLIETRG 347

  Fly   343 HD-----MNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYCDKDYDI--NGSIVPKGTTLNL 400
            .|     ....:.|.||.::.||...|.|..|:|||||...::.:.| |:  :|:.||.|:::..
plant   348 TDDVASWTEEPLGFDEIDRLVYLKAAISETLRLYPSVPEDSKHVEND-DVLPDGTFVPAGSSVTY 411

  Fly   401 ALILLGYNDRIF-KDPHHFRPERFEEEKPAPF------EYLPFSAGPRNCIGQKFALLELKTVIS 458
            ::...|.....: :|...|.|||:.......|      .::.|:||||.|:|:..|.|::||:.:
plant   412 SIYAAGRMKSTWGEDCLEFNPERWISPIDGKFINHDQYRFVAFNAGPRICLGKDLAYLQMKTIAA 476

  Fly   459 KVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYDPILSAVLTLKSDNGLHLRLRE 523
            .|:                  |...|.:.|..|::::..           |||...|||.:.|.:
plant   477 AVL------------------LRHRLTVVPGHKVEQKMS-----------LTLFMKNGLLVNLYK 512

  Fly   524 R 524
            |
plant   513 R 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	119/498 (24%)
CYP86A4	NP_171666.1	PLN03195	5..513	CDD:215627	135/584 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920