DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and CYP86A1

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_200694.1	Gene:	CYP86A1 / 836003	AraportID:	AT5G58860	Length:	513	Species:	Arabidopsis thaliana

Alignment Length:	588	Identity:	135/588 - (22%)
Similarity:	226/588 - (38%)	Gaps:	158/588 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AVLALLVLPLITLVYFERKASQRRQLLKEFNGPTPVPILGNANRIGKNPAEILSTFFDWWYDYGK 68
            ||.||.|..|  ..||         |.:...||..:|.:|:...:..|.:.|        :|:..
plant    12 AVAALSVYAL--WFYF---------LSRRLTGPKVLPFVGSLPYLIANRSRI--------HDWIA 57

  Fly    69 DNFLFWIG-YSS--------------HIVMTNPKQLEYILNSQQLIQKSTIYD----------LL 108
            ||.....| |.:              :.|..:||.:|:||        .|.:|          ..
plant    58 DNLRATGGTYQTCTMVIPFVAKAQGFYTVTCHPKNVEHIL--------KTRFDNYPKGPMWRAAF 114

  Fly   109 HPWLGHGLLTSFGSKWHKHRKMITPSFHFNILQDFHEVMNENSAKFMTQ---------LKKASAG 164
            |..||.|:..|.|..|...||  |.:..|..     ..:.:..|:::..         |.:|...
plant   115 HDLLGQGIFNSDGDTWLMQRK--TAALEFTT-----RTLRQAMARWVNGTIKNRLWLILDRAVQN 172

  Fly   165 DTIIDFQEHANYLTLDVICDTAMG---------VPINAMEQR-DSSIVQAFRDMCYNINMRAFHP 219
            :..:|.|:....||.|.||....|         :|.|..... |::.....:.:.|.    .|
plant   173 NKPVDLQDLFLRLTFDNICGLTFGKDPETLSLDLPDNPFSVAFDTATEATLKRLLYT----GF-- 231

  Fly   220 FKRSNRVFSLTPEFSAYQKTLKTLQDFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLS 284
            ..|..:...:..| ...:|:|:.::.:..|.|:.|           .:.||         |.|||
plant   232 LWRIQKAMGIGSE-DKLKKSLEVVETYMNDAIDAR-----------KNSPS---------DDLLS 275

  Fly   285 -----STIDGRPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQC----EV 340
                 ..::|..|....:......|:..|.||::..:|:..:|:..:.:|:.|:..|..    |.
plant   276 RFLKKRDVNGNVLPTDVLQRIALNFVLAGRDTSSVALSWFFWLVMNNREVETKIVNELSMVLKET 340

  Fly   341 MGHDMNR----SVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRY-CDKDYDINGSIVPKGTTLNL 400
            .|:|..:    .:.|.|..::.||...:.|..|:|||||...:| .|.|...:|:.||:|:|:..
plant   341 RGNDQEKWTEEPLEFDEADRLVYLKAALAETLRLYPSVPQDFKYVVDDDVLPDGTFVPRGSTVTY 405

  Fly   401 ALILLGYNDRIF-KDPHHFRP--------ERFEEEKPAPFEYLPFSAGPRNCIGQKFALLELKTV 456
            ::..:|....|: :|...|||        ||||..|.. ::::.|:||||.|:|:..|..::|:|
plant   406 SIYSIGRMKTIWGEDCLEFRPERWLTADGERFETPKDG-YKFVAFNAGPRTCLGKDLAYNQMKSV 469

  Fly   457 ISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYDPILSAVLTLKSDNGLHLRL 521
            .|.|:..:.|.|                  .|..:::::..           |||...|||.:.|
plant   470 ASAVLLRYRVFP------------------VPGHRVEQKMS-----------LTLFMKNGLRVYL 505

  Fly   522 RER 524
            :.|
plant   506 QPR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	116/499 (23%)
CYP86A1	NP_200694.1	CYP86A	70..501	CDD:410687	111/502 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920