DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e3 and CYP94B3

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_190421.1	Gene:	CYP94B3 / 824011	AraportID:	AT3G48520	Length:	506	Species:	Arabidopsis thaliana

Alignment Length:	563	Identity:	131/563 - (23%)
Similarity:	245/563 - (43%)	Gaps:	110/563 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VLALLVLP-LITLVYFERKASQRRQLLKEFNGPTPVPILGNANRIGKNPAEILSTFFDWWY---- 64
            :|:.|:|. |||:::|...:|.::.......||...|::|:.....||...:|.     ||
plant     4 LLSFLILAFLITIIFFLSSSSTKKVQENTTYGPPSYPLIGSILSFNKNRHRLLQ-----WYTELL 63

  Fly    65 --DYGKDNFLFWIGYSSHIVMTNPKQLEYIL--NSQQLIQKSTIYDLLHPWLGHGLLTSFGSKWH 125
              ...:...:..:|....|:.|||..:||||  |.....:.....|||...||.|:....|..|.
plant    64 RLSPSQTILVPLLGNRRTIITTNPLNVEYILKTNFFNFPKGKPFTDLLGDLLGGGIFNVDGHSWS 128

  Fly   126 KHRKMIT--------PSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVI 182
            ..||:.:        .||.|.:|:|  ||.|    :.:..|..|:...|.:|.|:.......||:
plant   129 SQRKLASHEFSTRSLRSFAFEVLKD--EVEN----RLVPVLSTAADVGTTVDLQDVLKRFAFDVV 187

  Fly   183 CDTAMG---------VPINAMEQRDSSIVQAFRDMCYNIN-MRAFHPFK---RSNRVFSLTPEFS 234
            |..::|         .|:|       .:|:|| |....|: .||..|..   ::.||.::..| .
plant   188 CKVSLGWDPDCLDLTRPVN-------PLVEAF-DTAAEISARRATEPIYAVWKTKRVLNVGSE-R 243

  Fly   235 AYQKTLKTLQDFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTIDGRPLTRQEIYE 299
            ..::.::|:.....:|:..:..:|:.|...|        .|...|...|::..:|     :.:.:
plant   244 KLREAIRTVHVLVSEIVRAKKKSLEIGTGAE--------AKQDLLSRFLAAGHNG-----EAVRD 295

  Fly   300 EVSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFI 364
            .|.:|:..|.|||::.:::..:||:.:.||:||:..|...:    ::..:.|:::.:|.|....:
plant   296 MVISFIMAGRDTTSAAMTWLFWLLTENDDVERKILEEVDPL----VSLGLGFEDLKEMAYTKACL 356

  Fly   365 KEAQRVYPSVPFIGRYCDKDYDI--NGSIVPKGTTLNLALILLGYNDRIF-KDPHHFRPERFEEE 426
            .||.|:||.|.:..::...| |:  :|:.|.:|..:......:|..:.:: .|...|.|.|:.:.
plant   357 CEAMRLYPPVSWDSKHAAND-DVLPDGTRVKRGDKVTYFPYGMGRMETLWGTDSEEFNPNRWFDS 420

  Fly   427 KP----------APFEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLN 481
            :|          :|:::..|.||||.|:|::.|.:::|.|:..|:..||::|.
plant   421 EPGSTRPVLKPISPYKFPVFQAGPRVCVGKEMAFMQMKYVVGSVLSRFEIVPV------------ 473

  Fly   482 TYLGLAPDEKLKREAGRHKYDPILSAVLTLKSDNGLHLRLRER 524
                             :|..|:...:||.....||.::::.|
plant   474 -----------------NKDRPVFVPLLTAHMAGGLKVKIKRR 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	115/474 (24%)
CYP94B3	NP_190421.1	p450	46..501	CDD:386267	119/521 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920