DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001003947.1	Gene:	Cyp4x1 / 81906	MGIID:	1932403	Length:	507	Species:	Mus musculus

Alignment Length:	555	Identity:	159/555 - (28%)
Similarity:	268/555 - (48%)	Gaps:	89/555 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WLAV-------LALLVLPLITLVYFERKASQRRQLLKE---FNGPTPVPILGNANRIGKNPAEIL 56
            ||..       |||:....:.|:...:...:|::||::   |.||....:||:...:.::..|.|
Mouse     5 WLETRWARPLHLALVFCLALVLMQAMKLYLRRQRLLRDLSPFPGPPAHWLLGHQKFLQEDNMETL 69

  Fly    57 STF-------FDWW--------YDYGKDNFLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTIYD 106
            ...       |..|        |.|..|....::.      .|:|| ::|            ::.
Mouse    70 DEIVKKHPCAFPCWVGPFQAFFYIYDPDYAKIFLS------RTDPK-MQY------------LHQ 115

  Fly   107 LLHPWLGHGLLTSFGSKWHKHRKMITPSFHFNILQDFHEVMNENSAKFMTQL--KKASAGDTIID 169
            ||.|.:|.|||...|.:|.:||.::||:||.:||:...:.| .:|.|.|...  |..:..:|.|:
Mouse   116 LLTPCIGRGLLNLDGPRWFQHRCLLTPAFHQDILKPCVDTM-AHSVKVMLDKWEKMWTTQETTIE 179

  Fly   170 FQEHANYLTLDVICDTAMGVPINA-MEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEF 233
            ..||.|.:|||:|...|.|...|. :.....|.|:|..::...|:.|.::.:...:.:|.|:|:.
Mouse   180 VFEHINLMTLDIIMKCAFGQETNCQINGTYESYVKATFELGEIISSRLYNFWHHHDIIFKLSPKG 244

  Fly   234 SAYQKTLKTLQDFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTI-DGRPLTRQEI 297
            ..:|:..|.:..:|..||:.|...|:|...::|...|     ..|||.:||:.. |.|..:..::
Mouse   245 HCFQELGKVIHQYTEKIIQDRKKILKNQVKQDDTQTS-----QIFLDIVLSAQAEDERAFSDADL 304

  Fly   298 YEEVSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDL 362
            ..||:|||:.|||.:.:.:|:.:|.|:.:|:.|.:...|...::|.  ..|::::::.:|.|..:
Mouse   305 RAEVNTFMWAGHDASAASISWLLYCLALNPEHQDRCRTEIRSILGD--GSSITWEQLDEMSYTTM 367

  Fly   363 FIKEAQRVYPSVPFIGRYCDKDYDI-NGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEE 426
            .|||..|:.|.||.|.|...|...: :|..:|.|.|:.|::..|.:|..::.||..|.|.||.:|
Mouse   368 CIKETLRLIPPVPSISRELSKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVWNDPKVFDPLRFTKE 432

  Fly   427 ---KPAPFEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAP 488
               :..|..:||||:||||||||:||:||||..|:.::..|:|                    ||
Mouse   433 NSDQRHPCAFLPFSSGPRNCIGQQFAMLELKVAIALILLHFQV--------------------AP 477

  Fly   489 DEKLKREAGRHKYDPILSAVLTLKSDNGLHLRLRE 523
            |  |.|       .|..|:...|:..:|::|.|::
Mouse   478 D--LTR-------PPAFSSHTVLRPKHGIYLHLKK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	138/455 (30%)
Cyp4x1	NP_001003947.1	p450	47..499	CDD:278495	147/507 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845094
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750