DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and CYP96A5

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_179782.1	Gene:	CYP96A5 / 816727	AraportID:	AT2G21910	Length:	510	Species:	Arabidopsis thaliana

Alignment Length:	589	Identity:	124/589 - (21%)
Similarity:	234/589 - (39%)	Gaps:	150/589 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LAVLALLVLPLITLVYF------ERKASQRRQLLKEFNGPTPVPILG-------NANRIGKNPAE 54
            :|.:.|:.:.:..||:|      .:|:.|..        |...|:||       ..:||....||
plant     1 MAYVGLVEVFIALLVFFFFHFLIHKKSHQIT--------PRNWPVLGMLPGVLVMLHRINDYVAE 57

  Fly    55 ILSTFFDWWYDYGKDNFLF-----WIGYSSHIVMTNPKQLEYILNSQ-QLIQKSTIYDLLHPWLG 113
            ||..          .|..|     |....:.::..:|..::::.:|. ....|...:..:..:||
plant    58 ILEV----------SNLTFAFKGPWFSGMNMLITADPSNIQHVFSSNFSNYDKGPEFKEMFDFLG 112

  Fly   114 HGLLTSFGSKWHKHRK--MITPSFHFNILQDFHEVMNENSAKFMT-QLKKA--------SAGDTI 167
            :|:.|:....|...||  ::..|         |:.....|.:.:| ::|..        :..:|:
plant   113 NGIFTADSKLWEDMRKSALVVLS---------HQGFQSFSLRTITCKIKNGLVPVLDHFAEANTV 168

  Fly   168 IDFQEHANYLTLDVI------CDT---AMGVPIN--AMEQRDSSIVQAFRDM-------CYN-IN 213
            .|.|:....|..||.      ||:   ::.:|.|  |....|:..|..:|.:       ..| |.
plant   169 FDLQDVFQRLAFDVTLTLVTGCDSSSLSIEMPKNEYAKAMDDAEEVVVYRHVKPVVLWKLQNWIG 233

  Fly   214 MRAFHPFKRSNRVF--SLTPEFSAYQKTLKTLQDFTYDIIEKRVYALQNGGSKEDHD-----PSL 271
            :......|.:|..|  |.....||.::          :||.   :....||.....|     .:|
plant   234 LGEEKKMKEANAAFDRSCAKYISAKRE----------EIIS---HHSNIGGEAHAEDLLSVYMNL 285

  Fly   272 PRKKMAFLDTLLSSTIDGRPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYRE 336
            ...|...|:          |.....:.:.:.:||..|.|...:.:::..:|||::|:...|:.:|
plant   286 DISKYELLN----------PNDDNFLKDIIKSFMLAGRDAIATTLTWFFWLLSKNPEAVTKIRQE 340

  Fly   337 -QCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYCDKDYDI--NGSIVPKGTTL 398
             ...:.|..|  |:...::.||.||...:.|:.|:|..:|| .|......|:  :|.:|.|...:
plant   341 INTNLPGSGM--SLDADKLNKMVYLHGALCESLRLYAPIPF-ERKTPIKQDVLPSGHMVDKNWKI 402

  Fly   399 NLALILLGYNDRIF-KDPHHFRPERFEEEK-------PAPFEYLPFSAGPRNCIGQKFALLELKT 455
            ..::..||....:: :|...|:|||:..|:       |: |::..|::|||||:|:..:.|::||
plant   403 LFSVYALGRMRSVWGQDASEFKPERWISERNGGLKHEPS-FKFFVFNSGPRNCLGKNLSFLQMKT 466

  Fly   456 VISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYDPILSAVLTLKSDNGLHLR 520
            |..:::|::::                           :....||.:|..|.:|.:|  :||.:.
plant   467 VAVEIIRNYDI---------------------------KVVEGHKIEPASSIILHMK--HGLKVT 502

  Fly   521 LRER 524
            :.:|
plant   503 VSKR 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	108/493 (22%)
CYP96A5	NP_179782.1	p450	1..506	CDD:299894	123/587 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H111093
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920