DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_077764.2	Gene:	Cyp4f18 / 72054	MGIID:	1919304	Length:	524	Species:	Mus musculus

Alignment Length:	545	Identity:	158/545 - (28%)
Similarity:	272/545 - (49%)	Gaps:	72/545 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WLAVL----ALLVLPLITLVYFERKASQRRQLLKEFNGPTPVP---ILGNANRIGKNPAEIL--- 56
            ||.:|    :.|:..::|.:|...:.|.|   |:.|  |.|..   |||:...|..:...:|
Mouse    19 WLLLLLAGASCLLAYILTPIYGVFENSLR---LRCF--PQPPKRNWILGHLGLIQSSEEGLLYIQ 78

  Fly    57 ---STFFDWWYDYGKDNFLFWIGYSSHIV-MTNPKQLEYILNSQQLI-QKSTI-YDLLHPWLGHG 115
               .||        :|...:|:|....:: :.:|..::.::.:..|: .|.|: |..|.||||.|
Mouse    79 SLVRTF--------RDACCWWVGPLHPVIRIFHPAFIKPVVLAPALVAPKDTVFYRFLKPWLGDG 135

  Fly   116 LLTSFGSKWHKHRKMITPSFHFNILQDFHEVMNENS----AKFMTQLKKASAGDTIIDFQEHANY 176
            ||.|.|.||.:||:|:||:||||||:.:.:|.|:::    ||:.   :.||.|...::..||.:.
Mouse   136 LLMSTGDKWSRHRRMLTPAFHFNILKPYVKVFNDSTNIMHAKWQ---RLASKGSAYLNMFEHISL 197

  Fly   177 LTLDVICDTAMGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLK 241
            :|||.:.........|..| :.|..:.|..::...:..|........:..:.||.:...::|..:
Mouse   198 MTLDSLQKCVFSFDSNCQE-KPSEYITAILELSTLVARRHQRLLLHVDLFYYLTHDGMRFRKACR 261

  Fly   242 TLQDFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTID-GRPLTRQEIYEEVSTFM 305
            .:.|||..:|.:|...|.:.|..:........|.:.|:|.||.|..: |:.|:.::|..|..|||
Mouse   262 LVHDFTDAVIRERRRTLLDQGGVDVLKAKAKAKTLDFIDVLLLSKDEHGKALSDEDIRAEADTFM 326

  Fly   306 FEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRV 370
            |.|||||.||:|:.:|.|:|||:.|.:..:|..|::.......:.:.::|::.:|.:.|||:.|:
Mouse   327 FGGHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLTMCIKESLRL 391

  Fly   371 YPSVPFIGRYCDKDYDI-NGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEK---PAPF 431
            :|.|..|.|.|.:|..: :|.::|||....:::....:|..::.||..:.|.||:.:.   .:|.
Mouse   392 HPPVTAISRCCTQDIVLPDGRVIPKGVISRISIFGTHHNPAVWPDPEVYDPFRFDADNVKGRSPL 456

  Fly   432 EYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREA 496
            .::||||||||||||.||:.|:|..::..:..|.||                    ||:|
Mouse   457 AFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRVL--------------------PDDK----- 496

  Fly   497 GRHKYDPILSAVLTLKSDNGLHLRL 521
                 :|.....|.|:::.||.|::
Mouse   497 -----EPRRKPELILRAEGGLWLKV 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	138/453 (30%)
Cyp4f18	NP_077764.2	p450	52..516	CDD:365848	148/505 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845238
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650