DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and Cyp4f16

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001343232.1	Gene:	Cyp4f16 / 70101	MGIID:	1917351	Length:	524	Species:	Mus musculus

Alignment Length:	468	Identity:	137/468 - (29%)
Similarity:	241/468 - (51%)	Gaps:	50/468 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 KDNFLFWIGYSSHIV-MTNPKQLEYILNSQQLI--QKSTIYDLLHPWLGHGLLTSFGSKWHKHRK 129
            :|..|||:|....:: :.:|..:..:|.:..|:  :..|....|.||||.||..|.|.||.:||:
Mouse    85 QDVHLFWLGPVIPVLRIVDPAFVAPLLQAPALVAPKDMTFLRFLKPWLGDGLFLSSGDKWSRHRR 149

  Fly   130 MITPSFHFNILQDFHEVMNENSAKFMTQLKK--ASAGDTIIDFQEHANYLTLDVICDTAMGVPIN 192
            ::||:|||:||:.:.::.|: |...|....|  :|.|...::..||.:.:|||.:.....|...|
Mouse   150 LLTPAFHFDILKPYVKIFNQ-SVNIMHAKWKHLSSEGSARLEMFEHISLMTLDSLQKCLFGFDSN 213

  Fly   193 AMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFTYDIIEKRVYA 257
            ..|. .|..:.|..::...|..|:...|...:.::..|.:...::|....:.:||..:|.:|.:.
Mouse   214 CQES-PSEYISAILELSSLIIKRSLQLFLFVDFLYYHTADGRRFRKACDLVHNFTDAVIRERRHT 277

  Fly   258 LQNGGSKEDHDPSL----PRKKMAFLDTLLSSTID-GRPLTRQEIYEEVSTFMFEGHDTTTSGVS 317
            |    |.::||..|    ..|.:.|:|.||.:..: |:.|:.::|..|..||||.|||||.|.:|
Mouse   278 L----SSQNHDEFLKSKTKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFGGHDTTASALS 338

  Fly   318 FSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYCD 382
            :.:|.|:|||:.|.:..:|..|::.......:.:.::|::.:|.:.|||:.|::..|..:.|.|.
Mouse   339 WILYNLARHPEYQERCRQEVQELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHSPVIDLLRRCT 403

  Fly   383 KDYDI-NGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKP---APFEYLPFSAGPRNC 443
            :|..: :|.::|||....:::..:.:|..::.||..:.|.||:.|.|   :|..::|||||||||
Mouse   404 RDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYDPFRFDPENPQKRSPLAFIPFSAGPRNC 468

  Fly   444 IGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYDPILSAV 508
            |||.||:.|:|..::..:..|.:|                    ||:|          :|.....
Mouse   469 IGQTFAMSEMKVALALTLLRFRIL--------------------PDDK----------EPRRKPE 503

  Fly   509 LTLKSDNGLHLRL 521
            :.|:::.||.||:
Mouse   504 IILRAEGGLWLRV 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	127/413 (31%)
Cyp4f16	NP_001343232.1	p450	52..514	CDD:306555	135/464 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845163
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640