DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e3 and cyp46a1.3

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001038763.1	Gene:	cyp46a1.3 / 692332	ZFINID:	ZDB-GENE-060519-40	Length:	491	Species:	Danio rerio

Alignment Length:	501	Identity:	134/501 - (26%)
Similarity:	228/501 - (45%)	Gaps:	61/501 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WLAVLALLVLPLITLVY--FERKASQRRQLLKEFNGPTPVP----ILGN---ANRIGKNPAEILS 57
            ||..:...:|..:.:|:  :.....|..|......||   |    :||:   .||:.|:...:..
Zfish     5 WLLYMVFYLLSAVFVVFLAYCLYIHQVHQKYDHIPGP---PRDNFLLGHIPTINRVTKSERHMND 66

  Fly    58 TFFDWWYDYGKDNFLFWIGYSSHIVMTN---PKQLEYILNSQQLIQKSTIYDLL-----HPWLGH 114
            ....|...||....|    .|.|.|:.|   |:..:.|:.|.:.::...||..|     ..:||:
Zfish    67 LLLIWAEKYGPVYRL----NSFHYVIINVHCPEATKTIMMSPKYLKDPFIYKRLFGLFGKRFLGY 127

  Fly   115 GLLTSFGSK-WHKHRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLT 178
            ||:|:.... |::.|:::.|:|..:.|:......||.|.:.|.:|::.:...|.....:..|.:|
Zfish   128 GLVTATDHDIWYRQRRIMDPAFSSSYLRGLISTFNEMSERLMDKLEEMAINKTPAVMHDLVNCVT 192

  Fly   179 LDVICDTAMGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKT---- 239
            ||:||..|.||.:|..:|.|:...||.......:.:....||.:     .....:.|.|:|
Zfish   193 LDIICKVAFGVDLNLFKQTDNPFQQAIEQCLQGMVLDLRDPFCK-----FFPKNWKAIQETKGAT 252

  Fly   240 ---LKTLQDFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMA-FLDTLLSSTIDGRPLTRQEIYEE 300
               .||.:.:    |:.|..|::.|   ||    :|...:. .|.|.....::... ..:::.:.
Zfish   253 VLLRKTGEQW----IQNRKTAVEIG---ED----VPNDILTQILKTAKEEKVNNTK-DHEQMLDN 305

  Fly   301 VSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIK 365
            ..||...|.:||.:.:||::..|.|||::.::...|..||:|  ..|.:|::::.|..||...:|
Zfish   306 FVTFFIAGQETTANQLSFAIMELGRHPEIYKRAKAEVDEVLG--TKRDISYEDLGKFTYLSQVLK 368

  Fly   366 EAQRVYPSVPFIGRYCDKDYDINGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKPAP 430
            |..|:||:.|...|:..:|..|||..:|.|.::..:..:....::.||||..|.||||....|.|
Zfish   369 ETLRLYPTAPGTNRWLHEDMVINGIKIPGGISVIFSSYVAQRLEKHFKDPLKFDPERFNVNAPKP 433

  Fly   431 FE-YLPFSAGPRNCIGQKF--------ALLELKTVISKVVRSFEVL 467
            :. |.|||.|||:|:||.|        ||.:|.|.:..:...|.::
Zfish   434 YYCYYPFSLGPRSCLGQVFSQATPAEGALAQLLTQLLTLCSHFLIV 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	128/466 (27%)
cyp46a1.3	NP_001038763.1	p450	39..452	CDD:278495	122/438 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820