Protein Alignment Cyp4e3 and Cyp3a57

DIOPT Version :10

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001093650.1
• Gene: Cyp3a57 / 622127
• MGIID: 3646373
• Length: 503
• Species: Mus musculus
• Alignment Length: 484
• Identity: 126/484 - (26%)
• Similarity: 239/484 - (49%)
• Gaps: 54/484 - (11%)

  Fly    10 VLPLITLVYFERKASQRRQLLKEFN--GPTPVPILGNANRIGKNPAEILSTFFD--WWYD----- 65
            ||.:.:||:|....:....|.|:..  ||.|:|:.||           :..:.|  |.:|
Mouse    13 VLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFGN-----------IINYLDGMWKFDDDCYK 66

  Fly    66 -YGKDNFLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTIYDLLHP-----WLGHGLLTSFGSKW 124
             ||| .:.|:.|....:.:.:|:.::.:|    :.:..:::....|     :|...:..|...:|
Mouse    67 KYGK-IWGFYEGPQPILAIMDPEIIKIVL----VKECYSVFTNRRPFGPVGFLKKSITISEDEEW 126

  Fly   125 HKHRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAMGV 189
            .:.|.:::|:|..:.|::...:|.:.....:..|::....:..|:.::.....::|||..|:.||
Mouse   127 KRLRTLLSPTFTSSKLKEMFPIMRQYGDILVRNLRREEEKEEPINMKDIFGAYSMDVITGTSCGV 191

  Fly   190 PINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFS-LTPEFSAYQKTLKTLQDFTYDIIEK 253
            .|:::.......||..:.:   :..:.|.||..|..:|. |||.:.....::...|...:  .:|
Mouse   192 NIDSLNNPQDPFVQKIKKI---LKFKFFDPFLLSVVLFPFLTPIYEMLNLSIFPRQSMNF--FKK 251

  Fly   254 RVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTIDG-----RPLTRQEIYEEVSTFMFEGHDTTT 313
            .|..:     |:|......:.::.||..::::....     :.|:..|:..:...|:|.|:|.|:
Mouse   252 FVKKM-----KKDRLDYNQKNRVDFLQLMMNTQNSKGQESLKALSDLEMAAQTLIFIFGGYDGTS 311

  Fly   314 SGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRS-VSFQEIAKMKYLDLFIKEAQRVYPSVPFI 377
            :.:||.:|.|:.|||||:||   |.|:.....|:: |::..:..|:|||:.:.|:.|:||.|..|
Mouse   312 TSISFIMYELATHPDVQKKL---QDEIDRALPNKAPVTYDALMDMEYLDMVVNESLRLYPVVSRI 373

  Fly   378 GRYCDKDYDINGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKPA---PFEYLPFSAG 439
            .|:..||.:|:|..:||||.:.:.:..|..:...:.:|..|.||||.:|...   |:.|:||..|
Mouse   374 DRFSKKDVEIHGVFIPKGTIVMIPIYPLHRDPEYWPEPEDFCPERFSKENKGNIDPYIYMPFGNG 438

  Fly   440 PRNCIGQKFALLELKTVISKVVRSFEVLP 468
            ||||||.:|||:.:|..::.|:::|.|.|
Mouse   439 PRNCIGMRFALISVKLAVTGVLQNFTVQP 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	CYP4	68..519	CDD:410721	108/416 (26%)
Cyp3a57	NP_001093650.1	cytochrome_P450	67..492	CDD:477761	110/419 (26%)