DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and Cyp3a25

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_062766.2	Gene:	Cyp3a25 / 56388	MGIID:	1930638	Length:	503	Species:	Mus musculus

Alignment Length:	529	Identity:	134/529 - (25%)
Similarity:	247/529 - (46%)	Gaps:	74/529 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLPLITLVYFERKASQRRQLLKEFN--GPTPVPILGNANRIGKNPAEILSTFFD--WWYD----- 65
            ||.:.:||.|....:....|.|:..  ||.|:|:||.           :..::|  |.:|
Mouse    13 VLLVTSLVLFYIYGTYSHGLFKKLGIPGPKPLPLLGT-----------IFNYYDGMWKFDEDCYK 66

  Fly    66 -YGKDNFLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTIYDLLHP--WLGHGLLTSFGSKWHKH 127
             ||| .:.|:.|....:.:.:|:.::.:| .::.....|......|  ::...:..|...:|.:.
Mouse    67 KYGK-IWGFYEGPQPILAIMDPEIIKIVL-VKECYSVFTNRRFFGPVGFMKKAITISEDEEWKRL 129

  Fly   128 RKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAMGVPIN 192
            |.:::|:|....|::...:|.:.....:..|::.......|..::.....::|||..|:.||.::
Mouse   130 RTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGEPISMKDIFGAYSMDVITGTSFGVNVD 194

  Fly   193 AMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFS-LTP-----EFSAYQK-TLKTLQDFTYDI 250
            ::.......||..:.:   :..:.|.||..|..:|. |||     .||.:.: ::...:.|.
Mouse   195 SLNNPQDPFVQKAKKI---LKFKIFDPFLLSIILFPFLTPIYEMLNFSIFPRDSMNFFKKFV--- 253

  Fly   251 IEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSS-----TIDGRPLTRQEIYEEVSTFMFEGHD 310
              ||:        |::...|..:.::.||..::::     ....:.|:..|:..:...|:|.|:|
Mouse   254 --KRM--------KKERLASNQKNRVDFLQLMMNTQNSKGQESQKALSDLEMAAQAVIFIFGGYD 308

  Fly   311 TTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRS-VSFQEIAKMKYLDLFIKEAQRVYPSV 374
            .|::.:|..:|.|:.|||||:||   |.|:.....|:: |::..:..|:|||:.:.|:.|:||..
Mouse   309 ATSTSISLIMYELATHPDVQKKL---QDEIDRTLPNKAPVTYDALMDMEYLDMVVNESLRLYPIA 370

  Fly   375 PFIGRYCDKDYDINGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKPA---PFEYLPF 436
            ..:.|...||.:|||..:||||.:.:.:..|..|...:.:|..|.||||.:|...   |:.|:||
Mouse   371 IRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKENKGNIDPYIYMPF 435

  Fly   437 SAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKY 501
            ..|||||||.:|||:.:|..:..|:::|.|.|..:          |.:.|    |:.||......
Mouse   436 GNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEE----------TQIPL----KISREPIFQPE 486

  Fly   502 DPILSAVLT 510
            .||:..|::
Mouse   487 KPIILKVVS 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	118/458 (26%)
Cyp3a25	NP_062766.2	p450	39..493	CDD:278495	126/499 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810