DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and cyp4v7

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001073465.1	Gene:	cyp4v7 / 562008	ZFINID:	ZDB-GENE-061103-88	Length:	510	Species:	Danio rerio

Alignment Length:	544	Identity:	184/544 - (33%)
Similarity:	288/544 - (52%)	Gaps:	64/544 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LAVLALLVLPLITLVYFERKASQRRQLLKEFNGPTPV-------PILGNANRIGKNPAEILSTFF 60
            |.:|.:|...::.|:......:..:..:.::|...|:       ||:|||.:...|..:    ||
Zfish     7 LYILGILFTAVLLLLLASTAYNPLKNYIGKWNEMRPIPGMAGAYPIIGNALQFKTNAGD----FF 67

  Fly    61 DWWYDYGKDN-----FLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTIYDLLHPWLGHGLLTSF 120
            :...:...:|     ...|:|....:::.:.:.:|.:|::.:.:.||..|..||||||.|||||.
Zfish    68 NQIIEGTNENRHLPLAKVWVGPVPFLILYHAENIEVVLSNSRHLDKSYSYRFLHPWLGTGLLTST 132

  Fly   121 GSKWHKHRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLT---LDVI 182
            |.||...|||:||:|||:||.||.|||||.:...:.:::|...|:....|    |::|   ||:|
Zfish   133 GEKWRNRRKMLTPTFHFSILSDFLEVMNEQTDILIQKMQKLEDGEPFNCF----NFITLCALDII 193

  Fly   183 CDTAMGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFT 247
            |:||||..|.|....||..||:...|...|..|...|:...:.:::...|...:.|.||.|..||
Zfish   194 CETAMGKKIYAQSNADSEYVQSVYKMSDIITKRQRAPWLWPDWIYNKLKEGKEHAKRLKILHSFT 258

  Fly   248 YDIIEKRVYALQNGGSKEDHDPSL-PRKKMAFLDTLLSSTID-GRPLTRQEIYEEVSTFMFEGHD 310
            .::|.:|...:   .|:.|.|... .||:.||||.||.:|.: |:.|:.::|.|||.||||||||
Zfish   259 ANVIRERAEFM---SSEPDSDSDQGERKRQAFLDMLLKTTYENGQKLSHEDIQEEVDTFMFEGHD 320

  Fly   311 TTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVP 375
            ||.:.::::::|:..||:||:.:..|..||.| ...|.|..:::.|::||:..|||:.|::||||
Zfish   321 TTAASMNWALHLIGSHPEVQKAVQAELQEVFG-SSERHVGVEDLKKLRYLECVIKESLRIFPSVP 384

  Fly   376 FIGRYCDKDYDINGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKPA---PFEYLPFS 437
            ...|...:...|||..||||....:....|..:.|.|.:|..|:||||..|...   |:.|:|||
Zfish   385 LFARSICEACHINGFKVPKGVNAVIIPYALHRDPRYFPEPEEFQPERFMPENSKGRHPYAYIPFS 449

  Fly   438 AGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREA--GRHK 500
            |||||||||:||::|.|.|::.::|.|:|                            ||  .|.:
Zfish   450 AGPRNCIGQRFAMMEEKVVLATILRHFDV----------------------------EACQSREE 486

  Fly   501 YDPILSAVLTLKSDNGLHLRLRER 524
            ..|:  ..|.|:.:.|:.::|:.|
Zfish   487 LRPL--GELILRPEKGIWIKLQRR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	170/452 (38%)
cyp4v7	NP_001073465.1	p450	44..505	CDD:278495	176/502 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589842
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.850