DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and cyp3a65

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001032515.1	Gene:	cyp3a65 / 553969	ZFINID:	ZDB-GENE-050604-1	Length:	517	Species:	Danio rerio

Alignment Length:	544	Identity:	131/544 - (24%)
Similarity:	226/544 - (41%)	Gaps:	85/544 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 W--LAVLALLVLPLITLVYFERKASQRRQLLKEFN--GPTPVPILGNANRIGKNPAEILSTFFDW 62
            |  ||.||.|:     ::|    .|...:..|:..  ||..:|..|...|. |:...:..  .|.
Zfish     8 WTLLAFLAALL-----VIY----GSWPHRYFKKLGIPGPKAIPFFGTMLRY-KDGFHVFD--MDC 60

  Fly    63 WYDYGKDNFLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTI---YDL--------LHPWLGHGL 116
            :..||:    .|..|..       :|....:..|.:|:...|   |.|        |:..|...:
Zfish    61 FEKYGR----IWGIYDG-------RQPVLCIMDQTIIKTVLIKECYSLFTNRRNFRLNGALYDAV 114

  Fly   117 LTSFGSKWHKHRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDV 181
            ..:....|.:.|.:::|||....|::...:|.::|...:..:.|.:......|.:|.....::||
Zfish   115 SIAEDDDWRRIRSVLSPSFTSGRLKEMFGIMKKHSHILVDSMGKTAKRGESADIKEFFGAYSMDV 179

  Fly   182 ICDTAMGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLK----- 241
            :..||..|.|:::.......|         .|::....|...|.:|.|...|......|:
Zfish   180 VTSTAFSVDIDSLNNPKDPFV---------TNIKKMLKFDLLNPLFLLIAFFPFMAPVLEKMDFA 235

  Fly   242 ----TLQDFTYDIIEKRVYALQNGGSKEDHDPSL-----PRKKMAFLDTLLSSTI------DG-- 289
                ::.||.|..::|         .|.|.|...     .:|::.||..::.|..      ||
Zfish   236 LFPTSVTDFFYAALQK---------IKSDRDTKTVAKDNTKKRVDFLQLMVDSQTGVKHKSDGEH 291

  Fly   290 --RPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQ 352
              :.|:..||..:...|:|.|::|::|.:||..|.|:.:|:..:||..|..|...:  ...|.::
Zfish   292 TEKGLSDHEILSQSMIFIFAGYETSSSTLSFLFYNLATNPETMKKLQEEIDETFPN--QAPVDYE 354

  Fly   353 EIAKMKYLDLFIKEAQRVYPSVPFIGRYCDKDYDINGSIVPKGTTLNLALILLGYNDRIFKDPHH 417
            .:..|.|||..:.|:.|::|....:.|.|.|..:|||.::||...:.:....|..:...:.:|..
Zfish   355 TLMSMDYLDAALSESLRLFPVAARLERVCKKTVEINGLLIPKDLVVMVPTYALHRDPDYWSEPES 419

  Fly   418 FRPERF---EEEKPAPFEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGR 479
            |:||||   .:|...|:.|:||..|||||||.:||.:.:|..|.::::.|:|....:..|..:..
Zfish   420 FKPERFTKGNKESIDPYMYMPFGLGPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETQVPLELG 484

  Fly   480 LNTYLGLAPDEKLKREAGRHKYDP 503
            .|..|......|||.:..:....|
Zfish   485 FNGLLSPKDPIKLKLQPRKLSQSP 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	115/470 (24%)
cyp3a65	NP_001032515.1	p450	35..499	CDD:278495	120/497 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810