Protein Alignment Cyp4e3 and cyp3a65

DIOPT Version :10

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001032515.2
• Gene: cyp3a65 / 553969
• ZFINID: ZDB-GENE-050604-1
• Length: 517
• Species: Danio rerio
• Alignment Length: 542
• Identity: 132/542 - (24%)
• Similarity: 226/542 - (41%)
• Gaps: 81/542 - (14%)

  Fly     2 WLAVLALLVLPLITLVYFERKASQRRQLLKEFN--GPTPVPILGNANRIGKNPAEILSTFFDWWY 64
            | .:||.||..|:  :|    .|...:..|:..  ||..:|..|...|. |:...:..  .|.:.
Zfish     8 W-TLLAFLVALLV--IY----GSWPHRYFKKLGIPGPKTIPFFGTMLRY-KDGFHVFD--MDCFE 62

  Fly    65 DYGKDNFLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTI---YDL--------LHPWLGHGLLT 118
            .||:    .|..|..       :|....:..|.:|:...|   |.|        |:..|...:..
Zfish    63 KYGR----IWGIYDG-------RQPVLCIMDQTIIKTVLIKECYSLFTNRRNFRLNGALYDAVSI 116

  Fly   119 SFGSKWHKHRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVIC 183
            :....|.:.|.:::|||....|::...:|.::|...:..:.|.:......|.:|.....::||:.
Zfish   117 AEDDDWRRIRSVLSPSFTSGRLKEMFGIMKKHSHILVDSMGKTAKRGESADIKEFFGAYSMDVVT 181

  Fly   184 DTAMGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLK------- 241
            .||..|.|:::.......|         .|::....|...|.:|.|...|......|:
Zfish   182 STAFSVDIDSLNNPKDPFV---------TNIKKMLKFDLLNPLFLLIAFFPFMAPVLEKMDFALF 237

  Fly   242 --TLQDFTYDIIEKRVYALQNGGSKEDHDPSL-----PRKKMAFLDTLLSSTI------DG---- 289
              ::.||.|..::|         .|.|.|...     .:|::.||..::.|..      ||
Zfish   238 PTSVTDFFYAALQK---------IKSDRDTKTVAKDNTKKRVDFLQLMVDSQTGVKHKSDGEHTE 293

  Fly   290 RPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEI 354
            :.|:..||..:...|:|.|::|::|.:||..|.|:.:|:..:||..|..|...:  ...|.::.:
Zfish   294 KGLSDHEILSQSMIFIFAGYETSSSTLSFLFYNLATNPETMKKLQEEIDETFPN--QAPVDYETL 356

  Fly   355 AKMKYLDLFIKEAQRVYPSVPFIGRYCDKDYDINGSIVPKGTTLNLALILLGYNDRIFKDPHHFR 419
            ..|.|||..:.|:.|:||....:.|.|.|..:|||.::||...:.:....|..:...:.:|..|:
Zfish   357 MSMDYLDAALSESLRLYPVAARLERVCKKTVEINGLLIPKDLVVMVPTYALHRDPDYWSEPESFK 421

  Fly   420 PERF---EEEKPAPFEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLN 481
            ||||   .:|...|:.|:||..|||||||.:||.:.:|..|.::::.|:|....:..|..:...|
Zfish   422 PERFTKGNKESIDPYMYMPFGLGPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETQVPLELGFN 486

  Fly   482 TYLGLAPDEKLKREAGRHKYDP 503
            ..|......|||.:..:....|
Zfish   487 GLLSPKDPIKLKLQPRKLSQSP 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	CYP4	68..519	CDD:410721	114/474 (24%)
cyp3a65	NP_001032515.2	cytochrome_P450	63..498	CDD:477761	113/465 (24%)