DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and Cyp6a17

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	130/553 - (23%)
Similarity:	248/553 - (44%)	Gaps:	87/553 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LAVLALLVLPLITLVYFERKAS---QRRQLLKEFNGPTPVPILGNANRIGKNPAEILSTFFDWWY 64
            :.:|||:|:.|..||:..|:..   |||.:..:    ...|:.||. :...|...|...|.|:::
  Fly     1 MLLLALIVVILSLLVFAARRRHGYWQRRGIPHD----EVHPLFGNI-KDWPNKRHIAEIFRDYYF 60

  Fly    65 DYGKDNFL---FWIGYSSHIVMTNPKQLEYIL--NSQQLIQKSTIYDLLHPWLGHGLLTSFGSKW 124
            .|...::.   |:..::...|:|:.:.|:.:|  :......:...|:.:...|...|.:..|.||
  Fly    61 KYKNSDYPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFENRGVFYNEIDDPLSATLFSIEGQKW 125

  Fly   125 HKHRKMITPSFHFNILQDFHEV---MNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTA 186
            ...|..:||:|....:::...:   :.|...|.......|..|..:......|.| |.|||.:.|
  Fly   126 RHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVDLVARY-TADVIGNCA 189

  Fly   187 MGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNR----VFSLTPEFS---AYQKTLKTLQ 244
            .|:..|::....:..|        :|..||....:..|.    :|.. |:.|   ..:..::..:
  Fly   190 FGLNCNSLYDPKAEFV--------SIGKRAITEHRYGNMLDIFLFGF-PKLSRRLRLKLNIQEAE 245

  Fly   245 DFTYDIIEKRV-YALQNGGSKEDHDPSLPRKKMAFLDTLL--------SSTIDGRPLTRQEIYEE 300
            ||...|:.:.: |.|:   :||        |:..|:|:|:        .::.||  ||..|:..:
  Fly   246 DFYTKIVRETIDYRLR---TKE--------KRNDFMDSLIEMYKNEQSGNSEDG--LTFNELLAQ 297

  Fly   301 VSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIK 365
            ...|...|.:|:::.:.|::|.|:|:.|||.||..|...|.|.. |:..:::.|.:||||:..:.
  Fly   298 AFIFFVAGFETSSTTMGFALYELARNQDVQDKLREEIGNVFGKH-NKEFTYEGIKEMKYLEQVVM 361

  Fly   366 EAQRVYPSVPFIGRYCDKDYDINGS--IVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKP 428
            |..|.||.:..:.|..|.|:.....  .:.|||.:.:..:.:.|:..|:.:|..|:||||.:|:.
  Fly   362 ETLRKYPVLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEEI 426

  Fly   429 A---PFEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDE 490
            |   ...:|||..|||||||.:|.:::....::.::|.::                  ..::|:.
  Fly   427 AARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYK------------------FSVSPET 473

  Fly   491 KLKREAGRHKYDPILSAVLTLKSDNGLHLRLRE 523
            ::..:        |:...:.:.::||:||::.:
  Fly   474 QIPMK--------IVVKNILISAENGIHLKVEK 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	113/461 (25%)
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	114/484 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810