DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e3 and Cyp4a30b

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	XP_006503285.1	Gene:	Cyp4a30b / 435802	MGIID:	3717145	Length:	510	Species:	Mus musculus

Alignment Length:	539	Identity:	152/539 - (28%)
Similarity:	266/539 - (49%)	Gaps:	70/539 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LAVLALLVLPLITLVYFERKASQRRQLLKEFN--GPTPVP--ILGNANRIGKNPAEIL------- 56
            :::|.||:|.|.:..|:    ..|:.|:|...  .|.|.|  :.||..: .::..:||
Mouse    22 VSLLGLLLLLLKSAQYY----LHRQWLIKSLQQFPPAPPPQWLFGNTLK-DQDLQQILLCVEKFP 81

  Fly    57 STFFDWWYDYGKDNFLFWIGYSSHIVMTNPKQLEYIL-NSQQLIQKSTIYDLLHPWLGHGLLTSF 120
            ||:..|          .| |..:.:|:.:|..::.|| .|...:.:|  |....||:|:|||...
Mouse    82 STYVRW----------LW-GNHARVVIYDPDYMKVILGRSDPKVVRS--YSFFAPWIGYGLLLLN 133

  Fly   121 GSKWHKHRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVI--C 183
            |.||.:||:|:||:||::||:.:..:|.::....:.:.::....|..::..:..:.:|::.:  |
Mouse   134 GKKWFQHRRMLTPAFHYDILKPYVGIMVDSVHVMLDKWEQLVDQDCPLEIYQDISLMTMETMMKC 198

  Fly   184 DTAMGVPINAMEQRDS-SIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFT 247
            ..:....:...:.|:| |.::|..|:.:.|.:|..:.|.::|.::||:....::....:.....|
Mouse   199 AFSYQGSVQLEDCRNSKSYIKAVEDLTHLIYLRVRNGFHQNNTIYSLSSNGRSFYHACQIAHKHT 263

  Fly   248 YDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLL-SSTIDGRPLTRQEIYEEVSTFMFEGHDT 311
            ..:|..|...|||....|..   ..:|::.|||.|| :.|.||:.|:.:::..|:.|||||||:|
Mouse   264 ERVIRMRKAQLQNEAELEKF---RKKKRLDFLDILLFAQTEDGKSLSDEDVRAEMDTFMFEGHNT 325

  Fly   312 TTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPF 376
            |.||:|:..|.|:.||:.|::...|...::|:  ..||:...:.:|.|..:.||||.|:||.:|.
Mouse   326 TASGISWIFYALATHPEHQQRCREEVKSILGN--GTSVTLNHLDQMPYTTMCIKEALRLYPPIPG 388

  Fly   377 IGRYCDKDYDI-NGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKP-APFEYLPFSAG 439
            ..|........ :|..:|||..:.|:...|.:|.|:..:...|.|.||....| ....:||||||
Mouse   389 ASRELSSPVTFPDGCSLPKGFLVTLSFYGLHHNPRLRPNAEVFDPSRFAPGAPRQTHAFLPFSAG 453

  Fly   440 PRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYDPI 504
            .|||||::|.:.|||..::..:..||:||....:                             ||
Mouse   454 TRNCIGKQFTMNELKVAVALTLLRFELLPDPTRV-----------------------------PI 489

  Fly   505 LSAVLTLKSDNGLHLRLRE 523
            |.:.:.|||.||::|..::
Mouse   490 LVSKIVLKSKNGIYLHTKK 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	132/448 (29%)
Cyp4a30b	XP_006503285.1	p450	59..504	CDD:365848	139/492 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845115
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650