DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and Cyp313a4

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster

Alignment Length:	502	Identity:	132/502 - (26%)
Similarity:	235/502 - (46%)	Gaps:	58/502 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWLAVLALLVLPLITLVYFERKASQRR--QLLKEFNGPTPVPILGNANRIGKNPAEILSTFFDWW 63
            :|..:|.||      .:||  ..|:||  .|..:..||...||||.|:.:.:. .:||:.|..:.
  Fly     6 LWCGLLFLL------WIYF--LWSRRRFYLLTLKIPGPLGYPILGMAHWLMRR-EDILNAFGCFL 61

  Fly    64 YDYGKDNFLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTIYDLLHPWLGHGLLTSFGSKWHKHR 128
            ..:|...| .|:|....:::::|:.::.|..|...:.|..||..:....|.||.:....:|..||
  Fly    62 DKHGPTIF-SWLGPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAVDDGAGVGLFSLKDPRWSIHR 125

  Fly   129 KMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAMGVPI-- 191
            |::.|:|...:|..|..:.|..:|..:.||:... .|...|........||.:...|.||..:
  Fly   126 KLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQ-DDGEKDLIPLLQSFTLGIATQTTMGSDVKD 189

  Fly   192 ------NAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFTYDI 250
                  |::..|...|::...|||       |.|:..|.....|..:.|.|.:....::.|...|
  Fly   190 EESFRSNSLLGRYQCILETMTDMC-------FSPWLNSRFCRQLAGKESHYYQAKTEIRQFIRKI 247

  Fly   251 IEKRVYALQNGGSKEDHDPSLP----RKKMAFLDTLLSSTIDGRPLTRQEIYEEVSTFMFEGHDT 311
            ||:::        .||...:||    ..|..||: |::..:.....|.:.:.:|.:..:|...:|
  Fly   248 IERKL--------AEDEMGALPSIQSNDKNLFLN-LVTDLMRRGVFTLKNVEDESNIIVFGAFET 303

  Fly   312 TTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPF 376
            |.:.|.:::.||:..|:.|.:.:.|...:..:..:..||:.:..:|.||||.:.|:.||.|.||.
  Fly   304 TANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQMVYLDLILNESMRVIPPVPV 368

  Fly   377 IGRYCDKDYDI-NGSIVPKGTTLNLALILLGYNDRIFK------DPHHFRPERFEEEKPAPFEYL 434
            :.|...:|..: ||.:||||..:.:.:..:..:.:|:.      :|.||.|...:::.  |:.|:
  Fly   369 VSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQDKH--PYAYI 431

  Fly   435 PFSAGPRNCIGQKFALLELKTVISKVVRS--------FEVLPAVDEL 473
            ||:.|.|||||.::||:..|..::|::|:        ||.|..|:::
  Fly   432 PFTKGIRNCIGWRYALISAKVTLAKLLRNYRFKTSFPFENLYFVEDI 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	120/459 (26%)
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	118/452 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.860