DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and Cyp313a2

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_650169.3	Gene:	Cyp313a2 / 41487	FlyBaseID:	FBgn0038006	Length:	493	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	127/510 - (24%)
Similarity:	233/510 - (45%)	Gaps:	71/510 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LAVLALLVLPLITLVYFERKASQRRQ---LLKEFNGPTPVPILGNANR---IGKNPAEILSTFFD 61
            :.|:.||:  ..:|:.:.|....||:   |:.:..|...:|:|||:.|   |.:......:|:.|
  Fly     1 MIVIQLLI--AASLILWIRFLWSRRKLYMLMMQLPGRMGLPLLGNSVRYLIISRGRMSSRTTYMD 63

  Fly    62 WWYDYGKDNFLFWIGYSSHIVMTNPKQLEYILNSQQLIQKST-IYDLLHPWLGHGLLTSFGSKWH 125
               .:| ..::.|||.:..::..:||..|.:|.|...|.:|: ..:.|...:|:||||..||||.
  Fly    64 ---KHG-STYMAWIGTTPIVITRDPKIAEKVLTSPFCINRSSQTTNALALSMGYGLLTLQGSKWM 124

  Fly   126 KHRKMITPSFHFNILQDFHEVMNENS-------AKFMTQLKKASAGDTIIDFQEHANYLTLDVIC 183
            ..||.:.|:|..::|..|..:.|..:       ..|:.|.:|....|.|        ..:..:..
  Fly   125 ARRKHMNPAFKHSVLLSFLPIFNAETDLLVSVFDSFVGQGEKDVLSDLI--------RWSFAIAT 181

  Fly   184 DTAMGVPINAMEQ-RDSSIVQAFRDMCYNINMRAFHPF---KRSNRVFSL----TPEFSAYQKTL 240
            .|.:|..:...:. .:.:|::.::.|.....:..|.||   |..:::|.|    ..:.||..|.:
  Fly   182 QTTLGTDVTKDDNFENDAILKTYQSMLRLTIINIFVPFVQNKIVSKLFGLEWLRRRDASAINKMI 246

  Fly   241 KTLQDFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTID---GRPLTRQEIYEEVS 302
            .       :|::|::     ..:.|::..|       .|.|::...|:   ...::..|:..|.|
  Fly   247 N-------NILDKKL-----NSNPENYCES-------ELKTVIHRAIELFRNDEMSLMELGAECS 292

  Fly   303 TFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEA 367
            :.:....:|:...|.:::.||:..|:.|..::.|..|.........|:..::.::.|||..:.|.
  Fly   293 SMVLAAFETSAHTVYYALVLLAMFPEHQEMVFNEIKEHFPLAKGIEVTHTDLQQLVYLDRVLNET 357

  Fly   368 QRVYPSVPFIGRYCDKDYDI-NGSIVPKGTTLNLALILLGYN-DRIFKDPHHFRPERFEEEK--- 427
            .|:.|||||..|...:|..: ||.::|||.|:::.:.....| |....:...|.||.|..||
  Fly   358 LRLMPSVPFSSRETLEDLRLSNGVVIPKGMTISIDIFNTQRNTDYWGSEAAQFNPENFLPEKIHD 422

  Fly   428 PAPFEYLPFSAGPRNCIGQKFALLELKTVISKVVRS--------FEVLPAVDELV 474
            ..|:.::|||.|.|||||.::.|:..|..:.|::|:        :|.|..||.:|
  Fly   423 RHPYAFIPFSKGKRNCIGWRYGLMSSKLALVKILRNYKLKTSFPYENLEFVDHMV 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	115/467 (25%)
Cyp313a2	NP_650169.3	p450	33..463	CDD:299894	114/460 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.860