Protein Alignment Cyp4e3 and CYP4F3

DIOPT Version :9

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Alignment Length: 465
• Identity: 142/465 - (30%)
• Similarity: 243/465 - (52%)
• Gaps: 46/465 - (9%)

  Fly    69 DNFLFWIG-YSSHIVMTNPKQLEYILNSQQLI--QKSTIYDLLHPWLGHGLLTSFGSKWHKHRKM 130
            |...:|:| :.:.:.:.:|..::.:|.:...|  :....|..|.||||.|||.|.|.||.:||:|
Human    86 DMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLSAGEKWSRHRRM 150

  Fly   131 ITPSFHFNILQDFHEVMNEN----SAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAMGVPI 191
            :||:||||||:.:.::.||:    .||:  || .||.|...:|..||.:.:|||.:.........
Human   151 LTPAFHFNILKPYMKIFNESVNIMHAKW--QL-LASEGSARLDMFEHISLMTLDSLQKCVFSFDS 212

  Fly   192 NAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFTYDIIEKRVY 256
            :..| :.|..:.|..::...:..|........:.::.|||:...:::..:.:.|||..:|::|..
Human   213 HCQE-KPSEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRR 276

  Fly   257 ALQNGGSKEDHDPSLPRKKMAFLDT-LLSSTIDGRPLTRQEIYEEVSTFMFEGHDTTTSGVSFSV 320
            .|.:.|..:........|.:.|:|. |||...||:.|:.::|..|..||||||||||.||:|:.:
Human   277 TLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVL 341

  Fly   321 YLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYCDKDY 385
            |.|::||:.|.:..:|..|::.....:.:.:.::|::.:|.:.|||:.|::|.||.:.|.|.:|.
Human   342 YHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDI 406

  Fly   386 DI-NGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEE---EKPAPFEYLPFSAGPRNCIGQ 446
            .: :|.::|||....:::....:|..::.||..:.|.||:.   ::.:|..::||||||||||||
Human   407 VLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQ 471

  Fly   447 KFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYDPILSAVLTL 511
            .||:.|:|.|:...:..|.|||...|                              |.....|.|
Human   472 AFAMAEMKVVLGLTLLRFRVLPDHTE------------------------------PRRKPELVL 506

  Fly   512 KSDNGLHLRL 521
            :::.||.||:
Human   507 RAEGGLWLRV 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	132/410 (32%)
CYP4F3	NP_000887.2	p450	52..515	CDD:365848	140/462 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154785
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650