DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e3 and Cyp312a1

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	163/523 - (31%)
Similarity:	278/523 - (53%)	Gaps:	41/523 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WLAV-LALLVLPLITLVYFERKASQRRQLLKEFNGPTPVPILGN----ANRIGKNP----AEILS 57
            ||.. |.||.|.|..|..|||: |:..:|..::..|..:|.:|:    |..:|.:|    .|:::
  Fly     3 WLGFGLLLLALSLYLLYVFERQ-SRIDRLTHKWPAPPALPFIGHLHILAKLVGPHPLRRATEMIN 66

  Fly    58 TFFDWWYDYGKDNFLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTIYDLLHPWLGHGLLTSFGS 122
               :..:|:   ....|:|...::|..|||.::.:.::|||:||:..|.:...||..||.||...
  Fly    67 ---EHLHDH---RAKLWMGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLFTSGFE 125

  Fly   123 KWHKHRKMITPSFHFNILQDFHEVMNENSAKFMTQLKK-ASAGDTIIDFQEHANYLTLDVICDTA 186
            ||...||::.|:|::.:::.|..|..:.|...:|.:.| |.:||. |||.:..:..|||.||:||
  Fly   126 KWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQ-IDFLQLISCFTLDTICETA 189

  Fly   187 MGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFTYDII 251
            :||.:.:.....|..:.|.:.:...|:.|..:.|.|::.:|..|..:...|:.:|||..||..||
  Fly   190 LGVSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHGFTEGII 254

  Fly   252 EKRVYALQNGGSKEDH---DPSLP--RKKMAFLDT-LLSSTIDGRPLTRQEIYEEVSTFMFEGHD 310
            :||:..:.......::   |..|.  ::.:.|||| |||...||:|||.::|.|||.|.:|.|.|
  Fly   255 QKRIDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGKPLTVKDIREEVDTIIFGGFD 319

  Fly   311 TTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVP 375
            .|.:.::|.:|.::.||:.|::...|...|.|.|.:..:|.:::.::::|:..|||..|:|||.|
  Fly   320 LTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETLRMYPSGP 384

  Fly   376 FIGRYCDKDYDINGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERF---EEEKPAPFEYLPFS 437
            ...|....:..||...:|||:.:.::.|.:|.....|.||..|:|:|:   .|.|.....::||.
  Fly   385 LTARKATANCTINDFFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRWAIGAEPKIEATTFIPFM 449

  Fly   438 AGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYD 502
            ||.|:|:||::|::.||.|::.::|:|...|..:..|..  :||..:.|            |..:
  Fly   450 AGARSCMGQRYAMVMLKMVLAHLLRNFLFEPLGERQVKL--KLNFVITL------------HTVE 500

  Fly   503 PIL 505
            |.|
  Fly   501 PYL 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	142/450 (32%)
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	150/490 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449055
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	10	9.900