DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e3 and Cyp4aa1

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	149/532 - (28%)
Similarity:	261/532 - (49%)	Gaps:	56/532 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AVLALLVLPLITLVYFERKASQRRQLL--KEFNGPTPVPILGNANRIGKNPAEILSTFFDWWYDY 66
            ::|.|||:.|....::....:..|.:|  ....||..:|.|||...:  ...:::.......:|.
  Fly    17 SILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPFLGNCMLV--TDKDLMRRCAGKAFDL 79

  Fly    67 GKDNFLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTIYDLLHPWLGHGLLTSFGSKWHKHRKMI 131
            .......|:.......:..|:.|:.||:|::...|...|.|:|.:||.||:||.||||..||::|
  Fly    80 YGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVFFYRLMHNFLGDGLITSSGSKWSNHRRLI 144

  Fly   132 TPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAMGVPINAMEQ 196
            .|:||.|:|:.|.:...:.|......|...:.| |.|:..::.|...||::.:..:||||....|
  Fly   145 QPAFHHNLLEKFIDTFVDASQSLYENLDAEAVG-TEINIAKYVNNCVLDILNEAVLGVPIKKRGQ 208

  Fly   197 RDSSIVQ--AFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFTYDIIEKR--VYA 257
             |.::::  .||.....:..|...|:...:.::..|...:......|.|.|||..:|::|  :..
  Fly   209 -DVAMMEDSPFRQGKIMMPARFTQPWLLLDGIYHWTKMANDELNQKKRLNDFTRKMIQRRRQIQN 272

  Fly   258 LQNGGSKEDHDPSLPRKKMAFLDTLLSSTIDGRPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYL 322
            ..||.|          ::...||.::..:...|..|.::|..|..|||..|.|:..:.|:|:::|
  Fly   273 NNNGNS----------ERKCLLDHMIEISESNRDFTEEDIVNEACTFMLAGQDSVGAAVAFTLFL 327

  Fly   323 LSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYCDKDYDI 387
            |:::|:.|.:...|...:. .|.||:.:..::.:|:|:::.||||.|:|||||.|.|...::..:
  Fly   328 LTQNPECQDRCVLELATIF-EDSNRAPTMTDLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRL 391

  Fly   388 NGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKPA---PFEYLPFSAGPRNCIGQKFA 449
            ....:|.|:.:.:..........|:.||..|:||||..|...   |:.:||||||||.|||.:||
  Fly   392 AKHTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENRHPYAFLPFSAGPRYCIGNRFA 456

  Fly   450 LLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYDPILSAV--LTLK 512
            ::|:||::|:::||:::||...:..                              ::|.  :||:
  Fly   457 IMEIKTIVSRLLRSYQLLPVTGKTT------------------------------IAATFRITLR 491

  Fly   513 SDNGLHLRLRER 524
            :..||.:||:||
  Fly   492 ASGGLWVRLKER 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	131/439 (30%)
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	131/439 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460468
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I1639
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	10	9.900