Protein Alignment Cyp4e3 and Cyp49a1

DIOPT Version :10

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_610588.2
• Gene: Cyp49a1 / 36105
• FlyBaseID: FBgn0033524
• Length: 589
• Species: Drosophila melanogaster
• Alignment Length: 570
• Identity: 134/570 - (23%)
• Similarity: 224/570 - (39%)
• Gaps: 169/570 - (29%)

  Fly    32 EFNGPTPVPILGNANRIGKNPAEILSTF---------FDWWYDYGK-DNFLFWIGYSSHIVMTNP 86
            |..||.|:|::||:.|.    |.::.|:         .:...:||| ......||:...:.:.:.
  Fly   102 EVPGPYPLPLIGNSWRF----APLIGTYKISDLDKVMNELHVNYGKMAKVGGLIGHPDLLFVFDG 162

  Fly    87 KQLEYILNSQQLIQKSTIYDLLHPWLGH----------GLLTSFGSKWHKHRKMITPSFHFNILQ 141
            .::..|...::.:........|..:.|.          ||:...|.||...|:.:.   |. :||
  Fly   163 DEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGDVAGLIGVHGPKWEAFRQEVQ---HI-LLQ 223

  Fly   142 -----DFHEVMNENSAKFMTQLKKASAGDTIIDFQEH--ANYL------TLD----VICDTAMGV 189
                 .:...:|:.:::||.::      :.:.|.::.  ||:|      .|:    |..||.:|.
  Fly   224 PQTAKKYIPPLNDIASEFMGRI------ELMRDEKDELPANFLHELYKWALESVGRVSLDTRLGC 282

  Fly   190 PINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEF------------SAYQKTLKT 242
            ......:....|::|.                  |..|...||.            .||:..:|.
  Fly   283 LSPEGSEEAQQIIEAI------------------NTFFWAVPELELRMPLWRIYPTKAYRSFVKA 329

  Fly   243 LQDFTYDIIEKRVYALQNGG---SKEDHDPSLPRKKMAFLDTLLSSTIDGRPLTRQE----IYEE 300
            |..||       ...::|.|   .|.|.|                   :.|.|::.|    |.|.
  Fly   330 LDQFT-------AICMKNIGKTMDKADAD-------------------EARGLSKSEADISIVER 368

  Fly   301 V---------------STFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGH---DMNR 347
            :               ..|:. |.|||:...|.::|.|:::||.|:||:.|..:|..|   |:|:
  Fly   369 IVRKTGNRKLAAILALDLFLV-GVDTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHREADINQ 432

  Fly   348 SVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYCDKDYDINGSIVPKGTTLNLALILLGYNDRIF 412
            :|    :.:|.||...:||..|:.|.|...||....|..|||..|||||.:....:::..:...|
  Fly   433 NV----LEQMPYLRACVKETLRMRPVVIANGRSLQSDAVINGYHVPKGTHVIFPHLVVSNDPAYF 493

  Fly   413 KDPHHFRPERF------------EEEKPAPFEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFE 465
            .:|..|.|||:            ..:|..||..|||..|.|.|:|::||.:||.|:::|:.|.::
  Fly   494 PEPKRFLPERWLKQSTDAAGCPHANQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYK 558

  Fly   466 VLPAVDELVSTDGRLN-TYLGLAPDEKLKREAGRHKYDPILSAVLTLKSD 514
            |.....|.|.   |:| ||:..:|                |:..|||:.:
  Fly   559 VSYNSGEFVY---RVNSTYIPQSP----------------LNFKLTLRDE 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	CYP4	68..519	CDD:410721	122/525 (23%)
Cyp49a1	NP_610588.2	CYP24A1-like	138..581	CDD:410677	120/520 (23%)